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Endocrine Reviews 20 (2): 207-239
Copyright © 1999 by The Endocrine Society

The Cadherin-Catenin System: Implications for Growth and Differentiation of Endocrine Tissues

Eyck Pötter, Clemens Bergwitz and Georg Brabant

Abteilung Klinische Endokrinologie, Zentrum Innere Medizin, Medizinische Hochschule Hannover, D-30625 Hannover, Germany

I. Introduction
II. Molecular Components and Subcellular Organization of the Cadherin-Catenin System
A. Cadherins, a large family of cell adhesion proteins
B. Structure-function relationships of classic cadherins
C. Catenins and the cadherin-catenin complex
III. Signal Transduction, Hormonal Regulation, and the Cadherin-Catenin System
A. Cadherin-catenins as targets of regulation
B. Cadherin-catenins as signal transducers
IV. Mouse Mutants
V. Implications of the Cadherin-Catenin System for Tumor Development and Prognosis of Tumors in Endocrine Tissues
VI. Summary and Conclusions




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