help button home button Endocrine Society Endocrine Reviews
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brigstock, D. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brigstock, D. R.
Endocrine Reviews 20 (2): 189-206
Copyright © 1999 by The Endocrine Society

The Connective Tissue Growth Factor/Cysteine- Rich 61/Nephroblastoma Overexpressed (CCN) Family1

David R. Brigstock

Departments of Surgery and Medical Biochemistry, The Ohio State University, Columbus, Ohio 43210; and Department of Surgery, Children’s Hospital, Columbus, Ohio 43205

I. Introduction
II. The Modular Structure of the Connective Tissue Growth Factor/Cysteine-Rich 61/Nephroblastoma Overexpressed (CCN) Family Members
III. Connective Tissue Growth Factor (CTGF)
A. Discovery
B. Structure of the CTGF gene and protein
C. CTGF mRNA production
D. CTGF production, secretion, and processing
E. CTGF-heparin interactions
F. Biological properties of CTGF
G. Mechanism of action of CTGF
IV. Cyr61
A. Discovery of cyr61
B. Structure of the cyr61 gene and protein
C. Cyr61 mRNA production
D. Cyr61 production and secretion
E. Biological properties of cyr61
F. Mechanism of action of cyr61
V. Nov
A. Discovery and structure of nov
B. Nov mRNA production
C. Biological properties of nov
VI. Elm1/WISP-1
VII. Heparin-Induced CCN-Like Protein (HICP)/rCop-1/CTGF-3/WISP-2
VIII. WISP-3
IX. Other CCN-Like Molecules
X. Regulation of Cellular Functions by the CCN Family
A. Cell cycle control
B. Cell adhesion and migration
C. Extracellular matrix (ECM) production
XI. Biological Processes Involving the CCN Family
A. Development and differentiation
B. Female reproductive tract function
C. Angiogenesis
D. Wound repair
E. Fibrotic disorders
F. Inflammation
G. Tumor growth
XII. Perspectives and Future Directions




This article has been cited by other articles:


Home page
J. Biol. Chem.Home page
S. A. Black Jr. and P. C. Trackman
Transforming Growth Factor-{beta}1 (TGF{beta}1) Stimulates Connective Tissue Growth Factor (CCN2/CTGF) Expression in Human Gingival Fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent Mechanism: STATINS WITH FORSKOLIN BLOCK TGF{beta}1-INDUCED CCN2/CTGF EXPRESSION
J. Biol. Chem., April 18, 2008; 283(16): 10835 - 10847.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
A. Fritah, C. Saucier, O. De Wever, M. Bracke, I. Bieche, R. Lidereau, C. Gespach, S. Drouot, G. Redeuilh, and M. Sabbah
Role of WISP-2/CCN5 in the Maintenance of a Differentiated and Noninvasive Phenotype in Human Breast Cancer Cells
Mol. Cell. Biol., February 1, 2008; 28(3): 1114 - 1123.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
Y.-Z. Deng, P.-P. Chen, Y. Wang, D. Yin, H. P. Koeffler, B. Li, X.-J. Tong, and D. Xie
Connective Tissue Growth Factor Is Overexpressed in Esophageal Squamous Cell Carcinoma and Promotes Tumorigenicity through -Catenin-T-cell Factor/Lef Signaling
J. Biol. Chem., December 14, 2007; 282(50): 36571 - 36581.
[Abstract] [Full Text] [PDF]


Home page
J. Histochem. Cytochem.Home page
M. Oka, S. Kubota, S. Kondo, T. Eguchi, C. Kuroda, K. Kawata, S. Minagi, and M. Takigawa
Gene Expression and Distribution of Connective Tissue Growth Factor (CCN2/CTGF) During Secondary Ossification Center Formation
J. Histochem. Cytochem., December 1, 2007; 55(12): 1245 - 1255.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
M.-T. Lin, C.-C. Chang, B.-R. Lin, H.-Y. Yang, C.-Y. Chu, M.-H. Wu, and M.-L. Kuo
Elevated Expression of Cyr61 Enhances Peritoneal Dissemination of Gastric Cancer Cells through Integrin {alpha}2beta1
J. Biol. Chem., November 23, 2007; 282(47): 34594 - 34604.
[Abstract] [Full Text] [PDF]


Home page
Mol Cancer ResHome page
B.-R. Lin, C.-C. Chang, L.-R. Chen, M.-H. Wu, M.-Y. Wang, I-H. Kuo, C.-Y. Chu, K.-J. Chang, P.-H. Lee, W.-J. Chen, et al.
Cysteine-Rich 61 (CCN1) Enhances Chemotactic Migration, Transendothelial Cell Migration, and Intravasation by Concomitantly Up-Regulating Chemokine Receptor 1 and 2
Mol. Cancer Res., November 1, 2007; 5(11): 1111 - 1123.
[Abstract] [Full Text] [PDF]


Home page
FASEB J.Home page
M. Guha, Z.-G. Xu, D. Tung, L. Lanting, and R. Natarajan
Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetes
FASEB J, October 1, 2007; 21(12): 3355 - 3368.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Renal Physiol.Home page
K. Sawai, M. Mukoyama, K. Mori, M. Kasahara, M. Koshikawa, H. Yokoi, T. Yoshioka, Y. Ogawa, A. Sugawara, H. Nishiyama, et al.
Expression of CCN1 (CYR61) in developing, normal, and diseased human kidney
Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1363 - F1372.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
R. Kikuchi, H. Tsuda, Y. Kanai, T. Kasamatsu, K. Sengoku, S. Hirohashi, J. Inazawa, and I. Imoto
Promoter Hypermethylation Contributes to Frequent Inactivation of a Putative Conditional Tumor Suppressor Gene Connective Tissue Growth Factor in Ovarian Cancer
Cancer Res., August 1, 2007; 67(15): 7095 - 7105.
[Abstract] [Full Text] [PDF]


Home page
Obstet GynecolHome page
S. D. MacLaughlan, W. A. Palomino, B. Mo, T. D. Lewis, R. A. Lininger, and B. A. Lessey
Endometrial Expression of Cyr61: A Marker of Estrogenic Activity in Normal and Abnormal Endometrium
Obstet. Gynecol., July 1, 2007; 110(1): 146 - 154.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Renal Physiol.Home page
L. A. Cooker, D. Peterson, J. Rambow, M. L. Riser, R. E. Riser, F. Najmabadi, D. Brigstock, and B. L. Riser
TNF-{alpha}, but not IFN-{gamma}, regulates CCN2 (CTGF), collagen type I, and proliferation in mesangial cells: possible roles in the progression of renal fibrosis
Am J Physiol Renal Physiol, July 1, 2007; 293(1): F157 - F165.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
S. A. Black Jr., A. H. Palamakumbura, M. Stan, and P. C. Trackman
Tissue-specific Mechanisms for CCN2/CTGF Persistence in Fibrotic Gingiva: INTERACTIONS BETWEEN cAMP AND MAPK SIGNALING PATHWAYS, AND PROSTAGLANDIN E2-EP3 RECEPTOR MEDIATED ACTIVATION OF THE c-JUN N-TERMINAL KINASE
J. Biol. Chem., May 25, 2007; 282(21): 15416 - 15429.
[Abstract] [Full Text] [PDF]


Home page
Poult. Sci.Home page
A. P. Gomez, M. J. Moreno, A. Iglesias, P. X. Coral, and A. Hernandez
Endothelin 1, its Endothelin Type A Receptor, Connective Tissue Growth Factor, Platelet-Derived Growth Factor, and Adrenomedullin Expression in Lungs of Pulmonary Hypertensive and Nonhypertensive Chickens
Poult. Sci., May 1, 2007; 86(5): 909 - 916.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
K. Dhar, S. Banerjee, G. Dhar, K. Sengupta, and S. K. Banerjee
Insulin-like Growth Factor-1 (IGF-1) Induces WISP-2/CCN5 via Multiple Molecular Cross-talks and Is Essential for Mitogenic Switch by IGF-1 Axis in Estrogen Receptor-Positive Breast Tumor Cells
Cancer Res., February 15, 2007; 67(4): 1520 - 1526.
[Abstract] [Full Text] [PDF]


Home page
J EndocrinolHome page
C. R Harlow, A. C Bradshaw, M. T Rae, K. D Shearer, and S. G Hillier
Oestrogen formation and connective tissue growth factor expression in rat granulosa cells
J. Endocrinol., January 1, 2007; 192(1): 41 - 52.
[Abstract] [Full Text] [PDF]


Home page
J EndocrinolHome page
A. Fritah, G. Redeuilh, and M. Sabbah
Molecular cloning and characterization of the human WISP-2/CCN5 gene promoter reveal its upregulation by oestrogens
J. Endocrinol., December 1, 2006; 191(3): 613 - 624.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
A. Cazes, A. Galaup, C. Chomel, M. Bignon, N. Brechot, S. Le Jan, H. Weber, P. Corvol, L. Muller, S. Germain, et al.
Extracellular Matrix-Bound Angiopoietin-Like 4 Inhibits Endothelial Cell Adhesion, Migration, and Sprouting and Alters Actin Cytoskeleton
Circ. Res., November 24, 2006; 99(11): 1207 - 1215.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Biol.Home page
M. Fukunaga-Kalabis, G. Martinez, Z.-J. Liu, J. Kalabis, P. Mrass, W. Weninger, S. M. Firth, N. Planque, B. Perbal, and M. Herlyn
CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1
J. Cell Biol., November 20, 2006; 175(4): 563 - 569.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
T. Quan, T. He, Y. Shao, L. Lin, S. Kang, J. J. Voorhees, and G. J. Fisher
Elevated Cysteine-Rich 61 Mediates Aberrant Collagen Homeostasis in Chronologically Aged and Photoaged Human Skin
Am. J. Pathol., August 1, 2006; 169(2): 482 - 490.
[Abstract] [Full Text] [PDF]


Home page
JNCI J Natl Cancer InstHome page
F. Tosetti, D. M. Noonan, and A. Albini
Choking hypoxia-inducible factor 1alpha: a novel mechanism for connective tissue growth factor inhibition of angiogenesis.
J Natl Cancer Inst, July 19, 2006; 98(14): 946 - 948.
[Full Text] [PDF]


Home page
GutHome page
R Gao and D R Brigstock
A novel integrin {alpha}5{beta}1 binding domain in module 4 of connective tissue growth factor (CCN2/CTGF) promotes adhesion and migration of activated pancreatic stellate cells
Gut, June 1, 2006; 55(6): 856 - 862.
[Abstract] [Full Text] [PDF]


Home page
Reproductive SciencesHome page
M. De Falco, S. Staibano, F. P. D'Armiento, M. Mascolo, G. Salvatore, A. Busiello, I. F. Carbone, F. Pollio, and A. Di Lieto
Preoperative Treatment of Uterine Leiomyomas: Clinical Findings and Expression of Transforming Growth Factor-{beta}3 and Connective Tissue Growth Factor
Reproductive Sciences, May 1, 2006; 13(4): 297 - 303.
[Abstract] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
T. Aikawa, J. Gunn, S. M. Spong, S. J. Klaus, and M. Korc
Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer
Mol. Cancer Ther., May 1, 2006; 5(5): 1108 - 1116.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. Zheng and A. Chen
Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor
Am J Physiol Gastrointest Liver Physiol, May 1, 2006; 290(5): G883 - G893.
[Abstract] [Full Text] [PDF]


Home page
J EndocrinolHome page
Z.-Y. Tong and D. R Brigstock
Intrinsic biological activity of the thrombospondin structural homology repeat in connective tissue growth factor.
J. Endocrinol., March 1, 2006; 188(3): R1 - R8.
[Abstract] [Full Text] [PDF]


Home page
Proc Am Thorac SocHome page
K. Ask, G. E. M. Martin, M. Kolb, and J. Gauldie
Targeting genes for treatment in idiopathic pulmonary fibrosis: challenges and opportunities, promises and pitfalls.
Proceedings of the ATS, January 1, 2006; 3(4): 389 - 393.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
S. Kondo, N. Tanaka, S. Kubota, Y. Mukudai, G. Yosimichi, T. Sugahara, and M. Takigawa
Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective tissue growth factor (CTGF/CCN2) by vascular endothelial growth factor in human endothelial cells
Mol. Cancer Ther., January 1, 2006; 5(1): 129 - 137.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
F. Yang, J. A. Tuxhorn, S. J. Ressler, S. J. McAlhany, T. D. Dang, and D. R. Rowley
Stromal Expression of Connective Tissue Growth Factor Promotes Angiogenesis and Prostate Cancer Tumorigenesis
Cancer Res., October 1, 2005; 65(19): 8887 - 8895.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
W. C. Duncan, S. G. Hillier, E. Gay, J. Bell, and H. M. Fraser
Connective Tissue Growth Factor Expression in the Human Corpus Luteum: Paracrine Regulation by Human Chorionic Gonadotropin
J. Clin. Endocrinol. Metab., September 1, 2005; 90(9): 5366 - 5376.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
M.-T. Lin, C.-Y. Zuon, C.-C. Chang, S.-T. Chen, C.-P. Chen, B.-R. Lin, M.-Y. Wang, Y.-M. Jeng, K.-J. Chang, P.-H. Lee, et al.
Cyr61 Induces Gastric Cancer Cell Motility/Invasion via Activation of the Integrin/Nuclear Factor-{kappa}B/Cyclooxygenase-2 Signaling Pathway
Clin. Cancer Res., August 15, 2005; 11(16): 5809 - 5820.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
Z. He, K. J. Way, E. Arikawa, E. Chou, D. M. Opland, A. Clermont, K. Isshiki, R. C. W. Ma, J. A. Scott, F. J. Schoen, et al.
Differential Regulation of Angiotensin II-induced Expression of Connective Tissue Growth Factor by Protein Kinase C Isoforms in the Myocardium
J. Biol. Chem., April 22, 2005; 280(16): 15719 - 15726.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
C. G. Lin, C.-C. Chen, S.-J. Leu, T. M. Grzeszkiewicz, and L. F. Lau
Integrin-dependent Functions of the Angiogenic Inducer NOV (CCN3): IMPLICATION IN WOUND HEALING
J. Biol. Chem., March 4, 2005; 280(9): 8229 - 8237.
[Abstract] [Full Text] [PDF]


Home page
Mol Cancer ResHome page
S. Banerjee, K. Sengupta, N. K. Saxena, K. Dhar, and S. K. Banerjee
Epidermal Growth Factor Induces WISP-2/CCN5 Expression in Estrogen Receptor-{alpha}-Positive Breast Tumor Cells through Multiple Molecular Cross-talks
Mol. Cancer Res., March 1, 2005; 3(3): 151 - 162.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
Y. Mukudai, S. Kubota, T. Eguchi, S. Kondo, K. Nakao, and M. Takigawa
Regulation of Chicken ccn2 Gene by Interaction between RNA cis-Element and Putative trans-Factor during Differentiation of Chondrocytes
J. Biol. Chem., February 4, 2005; 280(5): 3166 - 3177.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
W. E. Kutz, Y. Gong, and M. L. Warman
WISP3, the Gene Responsible for the Human Skeletal Disease Progressive Pseudorheumatoid Dysplasia, Is Not Essential for Skeletal Function in Mice
Mol. Cell. Biol., January 1, 2005; 25(1): 414 - 421.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
W. Chien, T. Kumagai, C. W. Miller, J. C. Desmond, J. M. Frank, J. W. Said, and H. P. Koeffler
Cyr61 Suppresses Growth of Human Endometrial Cancer Cells
J. Biol. Chem., December 17, 2004; 279(51): 53087 - 53096.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Renal Physiol.Home page
D. F. Higgins, M. P. Biju, Y. Akai, A. Wutz, R. S. Johnson, and V. H. Haase
Hypoxic induction of Ctgf is directly mediated by Hif-1
Am J Physiol Renal Physiol, December 1, 2004; 287(6): F1223 - F1232.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
M. Hermansson, Y. Sawaji, M. Bolton, S. Alexander, A. Wallace, S. Begum, R. Wait, and J. Saklatvala
Proteomic Analysis of Articular Cartilage Shows Increased Type II Collagen Synthesis in Osteoarthritis and Expression of Inhibin {beta}A (Activin A), a Regulatory Molecule for Chondrocytes
J. Biol. Chem., October 15, 2004; 279(42): 43514 - 43521.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
N. Chen, S.-J. Leu, V. Todorovic, S. C.-T. Lam, and L. F. Lau
Identification of a Novel Integrin {alpha}v{beta}3 Binding Site in CCN1 (CYR61) Critical for Pro-angiogenic Activities in Vascular Endothelial Cells
J. Biol. Chem., October 15, 2004; 279(42): 44166 - 44176.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
S.-J. Leu, N. Chen, C.-C. Chen, V. Todorovic, T. Bai, V. Juric, Y. Liu, G. Yan, S. C.-T. Lam, and L. F. Lau
Targeted Mutagenesis of the Angiogenic Protein CCN1 (CYR61): SELECTIVE INACTIVATION OF INTEGRIN {alpha}6{beta}1-HEPARAN SULFATE PROTEOGLYCAN CORECEPTOR-MEDIATED CELLULAR FUNCTIONS
J. Biol. Chem., October 15, 2004; 279(42): 44177 - 44187.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
A. M. Ramirez, S. Takagawa, M. Sekosan, H. A. Jaffe, J. Varga, and J. Roman
Smad3 Deficiency Ameliorates Experimental Obliterative Bronchiolitis in a Heterotopic Tracheal Transplantation Model
Am. J. Pathol., October 1, 2004; 165(4): 1223 - 1232.
[Abstract] [Full Text] [PDF]


Home page
Exp. Biol. Med.Home page
F. K. Askari, R. Dick, M. Mao, and G. J. Brewer
Tetrathiomolybdate Therapy Protects Against Concanavalin A and Carbon Tetrachloride Hepatic Damage in Mice
Experimental Biology and Medicine, September 1, 2004; 229(8): 857 - 863.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
D. M. French, R. J. Kaul, A. L. D'Souza, C. W. Crowley, M. Bao, G. D. Frantz, E. H. Filvaroff, and L. Desnoyers
WISP-1 Is an Osteoblastic Regulator Expressed During Skeletal Development and Fracture Repair
Am. J. Pathol., September 1, 2004; 165(3): 855 - 867.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
C. T. Fu, J. F. Bechberger, M. A. Ozog, B. Perbal, and C. C. Naus
CCN3 (NOV) Interacts with Connexin43 in C6 Glioma Cells: POSSIBLE MECHANISM OF CONNEXIN-MEDIATED GROWTH SUPPRESSION
J. Biol. Chem., August 27, 2004; 279(35): 36943 - 36950.
[Abstract] [Full Text] [PDF]


Home page
J. Am. Soc. Nephrol.Home page
H. Yokoi, M. Mukoyama, T. Nagae, K. Mori, T. Suganami, K. Sawai, T. Yoshioka, M. Koshikawa, T. Nishida, M. Takigawa, et al.
Reduction in Connective Tissue Growth Factor by Antisense Treatment Ameliorates Renal Tubulointerstitial Fibrosis
J. Am. Soc. Nephrol., June 1, 2004; 15(6): 1430 - 1440.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
S. Sakamoto, M. Yokoyama, X. Zhang, K. Prakash, K. Nagao, T. Hatanaka, R. H. Getzenberg, and Y. Kakehi
Increased Expression of CYR61, an Extracellular Matrix Signaling Protein, in Human Benign Prostatic Hyperplasia and Its Regulation by Lysophosphatidic Acid
Endocrinology, June 1, 2004; 145(6): 2929 - 2940.
[Abstract] [Full Text] [PDF]


Home page
Mol Hum ReprodHome page
Y. Absenger, H. Hess-Stumpp, B. Kreft, J. Kratzschmar, B. Haendler, N. Schutze, P.-A. Regidor, and E. Winterhager
Cyr61, a deregulated gene in endometriosis
Mol. Hum. Reprod., June 1, 2004; 10(6): 399 - 407.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
E. M. Tam, C. J. Morrison, Y. I. Wu, M. S. Stack, and C. M. Overall
Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates
PNAS, May 4, 2004; 101(18): 6917 - 6922.
[Abstract] [Full Text] [PDF]


Home page
Crit. Rev. Oral Biol. Med.Home page
P. C. Trackman and A. Kantarci
CONNECTIVE TISSUE METABOLISM AND GINGIVAL OVERGROWTH
Crit. Rev. Oral. Biol. Med., May 1, 2004; 15(3): 165 - 175.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Pathol.Home page
A W Rachfal, M H Luquette, and D R Brigstock
Expression of connective tissue growth factor (CCN2) in desmoplastic small round cell tumour
J. Clin. Pathol., April 1, 2004; 57(4): 422 - 425.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
D. Xie, D. Yin, H.-J. Wang, G.-T. Liu, R. Elashoff, K. Black, and H. P. Koeffler
Levels of Expression of CYR61 and CTGF Are Prognostic for Tumor Progression and Survival of Individuals with Gliomas
Clin. Cancer Res., March 15, 2004; 10(6): 2072 - 2081.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
R. Gao and D. R. Brigstock
Connective Tissue Growth Factor (CCN2) Induces Adhesion of Rat Activated Hepatic Stellate Cells by Binding of Its C-terminal Domain to Integrin {alpha}v{beta}3 and Heparan Sulfate Proteoglycan
J. Biol. Chem., March 5, 2004; 279(10): 8848 - 8855.
[Abstract] [Full Text] [PDF]


Home page
JNCI J Natl Cancer InstHome page
C.-C. Chang, J.-Y. Shih, Y.-M. Jeng, J.-L. Su, B.-Z. Lin, S.-T. Chen, Y.-P. Chau, P.-C. Yang, and M.-L. Kuo
Connective Tissue Growth Factor and Its Role in Lung Adenocarcinoma Invasion and Metastasis
J Natl Cancer Inst, March 3, 2004; 96(5): 364 - 375.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
S. Croci, L. Landuzzi, A. Astolfi, G. Nicoletti, A. Rosolen, F. Sartori, M. Y. Follo, N. Oliver, C. De Giovanni, P. Nanni, et al.
Inhibition of Connective Tissue Growth Factor (CTGF/CCN2) Expression Decreases the Survival and Myogenic Differentiation of Human Rhabdomyosarcoma Cells
Cancer Res., March 1, 2004; 64(5): 1730 - 1736.
[Abstract] [Full Text] [PDF]


Home page
J BiochemHome page
M. Minato, S. Kubota, H. Kawaki, T. Nishida, A. Miyauchi, H. Hanagata, T. Nakanishi, T. Takano-Yamamoto, and M. Takigawa
Module-Specific Antibodies against Human Connective Tissue Growth Factor: Utility for Structural and Functional Analysis of the Factor as Related to Chondrocytes
J. Biochem., March 1, 2004; 135(3): 347 - 354.
[Abstract] [Full Text] [PDF]


Home page
Mol Hum ReprodHome page
H. R. Mason, A. C. Lake, J. E. Wubben, R. A. Nowak, and J. J. Castellot Jr
The growth arrest-specific gene CCN5 is deficient in human leiomyomas and inhibits the proliferation and motility of cultured human uterine smooth muscle cells
Mol. Hum. Reprod., March 1, 2004; 10(3): 181 - 187.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
H. R. Mason, D. Grove-Strawser, B. S. Rubin, R. A. Nowak, and J. J. Castellot Jr.
Estrogen Induces CCN5 Expression in the Rat Uterus in Vivo
Endocrinology, February 1, 2004; 145(2): 976 - 982.
[Abstract] [Full Text] [PDF]


Home page
J Biomol ScreenHome page
S. Sakamoto, M. Yokoyama, K. Prakash, J.-I. Tsuruha, S. Masamoto, R. H. Getzenberg, and Y. Kakehi
Development of Quantitative Detection Assays for CYR61 as a New Marker for Benign Prostatic Hyperplasia
J Biomol Screen, December 1, 2003; 8(6): 701 - 711.
[Abstract] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
P. Bonniaud, P. J. Margetts, M. Kolb, T. Haberberger, M. Kelly, J. Robertson, and J. Gauldie
Adenoviral Gene Transfer of Connective Tissue Growth Factor in the Lung Induces Transient Fibrosis
Am. J. Respir. Crit. Care Med., October 1, 2003; 168(7): 770 - 778.
[Abstract] [Full Text] [PDF]


Home page
Mol Hum ReprodHome page
G. Weston, A. C. Trajstman, C. E. Gargett, U. Manuelpillai, B. J. Vollenhoven, and P. A.W. Rogers
Fibroids display an anti-angiogenic gene expression profile when compared with adjacent myometrium
Mol. Hum. Reprod., September 1, 2003; 9(9): 541 - 549.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
Y. Liang, C. Li, V. M. Guzman, A. J. Evinger III, C. E. Protzman, A. H.-P. Krauss, an