The Connective Tissue Growth Factor/Cysteine- Rich 61/Nephroblastoma Overexpressed (CCN) Family1
David R. Brigstock
Departments of Surgery and Medical Biochemistry, The Ohio State
University, Columbus, Ohio 43210; and Department of Surgery,
Childrens Hospital, Columbus, Ohio 43205
I. Introduction
II. The Modular Structure of the ConnectiveTissue Growth
Factor/Cysteine-Rich61/Nephroblastoma Overexpressed(CCN)
Family Members
III. Connective Tissue Growth Factor(CTGF)
A. Discovery
B. Structure of the CTGF gene and protein
C. CTGF mRNA production
D. CTGF production, secretion, andprocessing
E. CTGF-heparin interactions
F. Biological propertiesof CTGF
G. Mechanism of action of CTGF
IV. Cyr61
A. Discoveryof cyr61
B. Structure of the cyr61 gene and protein
C. Cyr61mRNA production
D. Cyr61 production and secretion
E. Biologicalproperties of cyr61
F. Mechanism of action of cyr61
V. Nov
A. Discovery and structure of nov
B. Nov mRNA production
C. Biological properties of nov
VI. Elm1/WISP-1
VII. Heparin-InducedCCN-Like Protein (HICP)/rCop-1/CTGF-3/WISP-2
VIII. WISP-3
IX. Other CCN-Like Molecules
X. Regulation of Cellular Functionsby the CCN Family
A. Cell cycle control
B. Cell adhesionand migration
C. Extracellular matrix (ECM) production
XI.Biological Processes Involving the CCN Family
A. Developmentand differentiation
B. Female reproductive tract function
C. Angiogenesis
D. Wound repair
E. Fibrotic disorders
F. Inflammation
G. Tumor growth
XII. Perspectives andFuture Directions
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28(3):
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December 14, 2007;
282(50):
36571 - 36581.
[Abstract][Full Text][PDF]
M. Oka, S. Kubota, S. Kondo, T. Eguchi, C. Kuroda, K. Kawata, S. Minagi, and M. Takigawa Gene Expression and Distribution of Connective Tissue Growth Factor (CCN2/CTGF) During Secondary Ossification Center Formation
J. Histochem. Cytochem.,
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55(12):
1245 - 1255.
[Abstract][Full Text][PDF]
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November 23, 2007;
282(47):
34594 - 34604.
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November 1, 2007;
5(11):
1111 - 1123.
[Abstract][Full Text][PDF]
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October 1, 2007;
21(12):
3355 - 3368.
[Abstract][Full Text][PDF]
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Am J Physiol Renal Physiol,
October 1, 2007;
293(4):
F1363 - F1372.
[Abstract][Full Text][PDF]
R. Kikuchi, H. Tsuda, Y. Kanai, T. Kasamatsu, K. Sengoku, S. Hirohashi, J. Inazawa, and I. Imoto Promoter Hypermethylation Contributes to Frequent Inactivation of a Putative Conditional Tumor Suppressor Gene Connective Tissue Growth Factor in Ovarian Cancer
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August 1, 2007;
67(15):
7095 - 7105.
[Abstract][Full Text][PDF]
L. A. Cooker, D. Peterson, J. Rambow, M. L. Riser, R. E. Riser, F. Najmabadi, D. Brigstock, and B. L. Riser TNF-{alpha}, but not IFN-{gamma}, regulates CCN2 (CTGF), collagen type I, and proliferation in mesangial cells: possible roles in the progression of renal fibrosis
Am J Physiol Renal Physiol,
July 1, 2007;
293(1):
F157 - F165.
[Abstract][Full Text][PDF]
S. A. Black Jr., A. H. Palamakumbura, M. Stan, and P. C. Trackman Tissue-specific Mechanisms for CCN2/CTGF Persistence in Fibrotic Gingiva: INTERACTIONS BETWEEN cAMP AND MAPK SIGNALING PATHWAYS, AND PROSTAGLANDIN E2-EP3 RECEPTOR MEDIATED ACTIVATION OF THE c-JUN N-TERMINAL KINASE
J. Biol. Chem.,
May 25, 2007;
282(21):
15416 - 15429.
[Abstract][Full Text][PDF]
A. P. Gomez, M. J. Moreno, A. Iglesias, P. X. Coral, and A. Hernandez Endothelin 1, its Endothelin Type A Receptor, Connective Tissue Growth Factor, Platelet-Derived Growth Factor, and Adrenomedullin Expression in Lungs of Pulmonary Hypertensive and Nonhypertensive Chickens
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May 1, 2007;
86(5):
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[Abstract][Full Text][PDF]
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February 15, 2007;
67(4):
1520 - 1526.
[Abstract][Full Text][PDF]
C. R Harlow, A. C Bradshaw, M. T Rae, K. D Shearer, and S. G Hillier Oestrogen formation and connective tissue growth factor expression in rat granulosa cells
J. Endocrinol.,
January 1, 2007;
192(1):
41 - 52.
[Abstract][Full Text][PDF]
A. Fritah, G. Redeuilh, and M. Sabbah Molecular cloning and characterization of the human WISP-2/CCN5 gene promoter reveal its upregulation by oestrogens
J. Endocrinol.,
December 1, 2006;
191(3):
613 - 624.
[Abstract][Full Text][PDF]
A. Cazes, A. Galaup, C. Chomel, M. Bignon, N. Brechot, S. Le Jan, H. Weber, P. Corvol, L. Muller, S. Germain, et al. Extracellular Matrix-Bound Angiopoietin-Like 4 Inhibits Endothelial Cell Adhesion, Migration, and Sprouting and Alters Actin Cytoskeleton
Circ. Res.,
November 24, 2006;
99(11):
1207 - 1215.
[Abstract][Full Text][PDF]
M. Fukunaga-Kalabis, G. Martinez, Z.-J. Liu, J. Kalabis, P. Mrass, W. Weninger, S. M. Firth, N. Planque, B. Perbal, and M. Herlyn CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1
J. Cell Biol.,
November 20, 2006;
175(4):
563 - 569.
[Abstract][Full Text][PDF]
T. Quan, T. He, Y. Shao, L. Lin, S. Kang, J. J. Voorhees, and G. J. Fisher Elevated Cysteine-Rich 61 Mediates Aberrant Collagen Homeostasis in Chronologically Aged and Photoaged Human Skin
Am. J. Pathol.,
August 1, 2006;
169(2):
482 - 490.
[Abstract][Full Text][PDF]
F. Tosetti, D. M. Noonan, and A. Albini Choking hypoxia-inducible factor 1alpha: a novel mechanism for connective tissue growth factor inhibition of angiogenesis.
J Natl Cancer Inst,
July 19, 2006;
98(14):
946 - 948.
[Full Text][PDF]
R Gao and D R Brigstock A novel integrin {alpha}5{beta}1 binding domain in module 4 of connective tissue growth factor (CCN2/CTGF) promotes adhesion and migration of activated pancreatic stellate cells
Gut,
June 1, 2006;
55(6):
856 - 862.
[Abstract][Full Text][PDF]
M. De Falco, S. Staibano, F. P. D'Armiento, M. Mascolo, G. Salvatore, A. Busiello, I. F. Carbone, F. Pollio, and A. Di Lieto Preoperative Treatment of Uterine Leiomyomas: Clinical Findings and Expression of Transforming Growth Factor-{beta}3 and Connective Tissue Growth Factor
Reproductive Sciences,
May 1, 2006;
13(4):
297 - 303.
[Abstract][PDF]
T. Aikawa, J. Gunn, S. M. Spong, S. J. Klaus, and M. Korc Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer
Mol. Cancer Ther.,
May 1, 2006;
5(5):
1108 - 1116.
[Abstract][Full Text][PDF]
S. Zheng and A. Chen Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor
Am J Physiol Gastrointest Liver Physiol,
May 1, 2006;
290(5):
G883 - G893.
[Abstract][Full Text][PDF]
Z.-Y. Tong and D. R Brigstock Intrinsic biological activity of the thrombospondin structural homology repeat in connective tissue growth factor.
J. Endocrinol.,
March 1, 2006;
188(3):
R1 - R8.
[Abstract][Full Text][PDF]
K. Ask, G. E. M. Martin, M. Kolb, and J. Gauldie Targeting genes for treatment in idiopathic pulmonary fibrosis: challenges and opportunities, promises and pitfalls.
Proceedings of the ATS,
January 1, 2006;
3(4):
389 - 393.
[Abstract][Full Text][PDF]
S. Kondo, N. Tanaka, S. Kubota, Y. Mukudai, G. Yosimichi, T. Sugahara, and M. Takigawa Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective tissue growth factor (CTGF/CCN2) by vascular endothelial growth factor in human endothelial cells
Mol. Cancer Ther.,
January 1, 2006;
5(1):
129 - 137.
[Abstract][Full Text][PDF]
F. Yang, J. A. Tuxhorn, S. J. Ressler, S. J. McAlhany, T. D. Dang, and D. R. Rowley Stromal Expression of Connective Tissue Growth Factor Promotes Angiogenesis and Prostate Cancer Tumorigenesis
Cancer Res.,
October 1, 2005;
65(19):
8887 - 8895.
[Abstract][Full Text][PDF]
W. C. Duncan, S. G. Hillier, E. Gay, J. Bell, and H. M. Fraser Connective Tissue Growth Factor Expression in the Human Corpus Luteum: Paracrine Regulation by Human Chorionic Gonadotropin
J. Clin. Endocrinol. Metab.,
September 1, 2005;
90(9):
5366 - 5376.
[Abstract][Full Text][PDF]
M.-T. Lin, C.-Y. Zuon, C.-C. Chang, S.-T. Chen, C.-P. Chen, B.-R. Lin, M.-Y. Wang, Y.-M. Jeng, K.-J. Chang, P.-H. Lee, et al. Cyr61 Induces Gastric Cancer Cell Motility/Invasion via Activation of the Integrin/Nuclear Factor-{kappa}B/Cyclooxygenase-2 Signaling Pathway
Clin. Cancer Res.,
August 15, 2005;
11(16):
5809 - 5820.
[Abstract][Full Text][PDF]
Z. He, K. J. Way, E. Arikawa, E. Chou, D. M. Opland, A. Clermont, K. Isshiki, R. C. W. Ma, J. A. Scott, F. J. Schoen, et al. Differential Regulation of Angiotensin II-induced Expression of Connective Tissue Growth Factor by Protein Kinase C Isoforms in the Myocardium
J. Biol. Chem.,
April 22, 2005;
280(16):
15719 - 15726.
[Abstract][Full Text][PDF]
C. G. Lin, C.-C. Chen, S.-J. Leu, T. M. Grzeszkiewicz, and L. F. Lau Integrin-dependent Functions of the Angiogenic Inducer NOV (CCN3): IMPLICATION IN WOUND HEALING
J. Biol. Chem.,
March 4, 2005;
280(9):
8229 - 8237.
[Abstract][Full Text][PDF]
S. Banerjee, K. Sengupta, N. K. Saxena, K. Dhar, and S. K. Banerjee Epidermal Growth Factor Induces WISP-2/CCN5 Expression in Estrogen Receptor-{alpha}-Positive Breast Tumor Cells through Multiple Molecular Cross-talks
Mol. Cancer Res.,
March 1, 2005;
3(3):
151 - 162.
[Abstract][Full Text][PDF]
Y. Mukudai, S. Kubota, T. Eguchi, S. Kondo, K. Nakao, and M. Takigawa Regulation of Chicken ccn2 Gene by Interaction between RNA cis-Element and Putative trans-Factor during Differentiation of Chondrocytes
J. Biol. Chem.,
February 4, 2005;
280(5):
3166 - 3177.
[Abstract][Full Text][PDF]
W. E. Kutz, Y. Gong, and M. L. Warman WISP3, the Gene Responsible for the Human Skeletal Disease Progressive Pseudorheumatoid Dysplasia, Is Not Essential for Skeletal Function in Mice
Mol. Cell. Biol.,
January 1, 2005;
25(1):
414 - 421.
[Abstract][Full Text][PDF]
W. Chien, T. Kumagai, C. W. Miller, J. C. Desmond, J. M. Frank, J. W. Said, and H. P. Koeffler Cyr61 Suppresses Growth of Human Endometrial Cancer Cells
J. Biol. Chem.,
December 17, 2004;
279(51):
53087 - 53096.
[Abstract][Full Text][PDF]
D. F. Higgins, M. P. Biju, Y. Akai, A. Wutz, R. S. Johnson, and V. H. Haase Hypoxic induction of Ctgf is directly mediated by Hif-1
Am J Physiol Renal Physiol,
December 1, 2004;
287(6):
F1223 - F1232.
[Abstract][Full Text][PDF]
M. Hermansson, Y. Sawaji, M. Bolton, S. Alexander, A. Wallace, S. Begum, R. Wait, and J. Saklatvala Proteomic Analysis of Articular Cartilage Shows Increased Type II Collagen Synthesis in Osteoarthritis and Expression of Inhibin {beta}A (Activin A), a Regulatory Molecule for Chondrocytes
J. Biol. Chem.,
October 15, 2004;
279(42):
43514 - 43521.
[Abstract][Full Text][PDF]
N. Chen, S.-J. Leu, V. Todorovic, S. C.-T. Lam, and L. F. Lau Identification of a Novel Integrin {alpha}v{beta}3 Binding Site in CCN1 (CYR61) Critical for Pro-angiogenic Activities in Vascular Endothelial Cells
J. Biol. Chem.,
October 15, 2004;
279(42):
44166 - 44176.
[Abstract][Full Text][PDF]
S.-J. Leu, N. Chen, C.-C. Chen, V. Todorovic, T. Bai, V. Juric, Y. Liu, G. Yan, S. C.-T. Lam, and L. F. Lau Targeted Mutagenesis of the Angiogenic Protein CCN1 (CYR61): SELECTIVE INACTIVATION OF INTEGRIN {alpha}6{beta}1-HEPARAN SULFATE PROTEOGLYCAN CORECEPTOR-MEDIATED CELLULAR FUNCTIONS
J. Biol. Chem.,
October 15, 2004;
279(42):
44177 - 44187.
[Abstract][Full Text][PDF]
A. M. Ramirez, S. Takagawa, M. Sekosan, H. A. Jaffe, J. Varga, and J. Roman Smad3 Deficiency Ameliorates Experimental Obliterative Bronchiolitis in a Heterotopic Tracheal Transplantation Model
Am. J. Pathol.,
October 1, 2004;
165(4):
1223 - 1232.
[Abstract][Full Text][PDF]
F. K. Askari, R. Dick, M. Mao, and G. J. Brewer Tetrathiomolybdate Therapy Protects Against Concanavalin A and Carbon Tetrachloride Hepatic Damage in Mice
Exp Biol Med,
September 1, 2004;
229(8):
857 - 863.
[Abstract][Full Text][PDF]
D. M. French, R. J. Kaul, A. L. D'Souza, C. W. Crowley, M. Bao, G. D. Frantz, E. H. Filvaroff, and L. Desnoyers WISP-1 Is an Osteoblastic Regulator Expressed During Skeletal Development and Fracture Repair
Am. J. Pathol.,
September 1, 2004;
165(3):
855 - 867.
[Abstract][Full Text][PDF]
C. T. Fu, J. F. Bechberger, M. A. Ozog, B. Perbal, and C. C. Naus CCN3 (NOV) Interacts with Connexin43 in C6 Glioma Cells: POSSIBLE MECHANISM OF CONNEXIN-MEDIATED GROWTH SUPPRESSION
J. Biol. Chem.,
August 27, 2004;
279(35):
36943 - 36950.
[Abstract][Full Text][PDF]
H. Yokoi, M. Mukoyama, T. Nagae, K. Mori, T. Suganami, K. Sawai, T. Yoshioka, M. Koshikawa, T. Nishida, M. Takigawa, et al. Reduction in Connective Tissue Growth Factor by Antisense Treatment Ameliorates Renal Tubulointerstitial Fibrosis
J. Am. Soc. Nephrol.,
June 1, 2004;
15(6):
1430 - 1440.
[Abstract][Full Text][PDF]
S. Sakamoto, M. Yokoyama, X. Zhang, K. Prakash, K. Nagao, T. Hatanaka, R. H. Getzenberg, and Y. Kakehi Increased Expression of CYR61, an Extracellular Matrix Signaling Protein, in Human Benign Prostatic Hyperplasia and Its Regulation by Lysophosphatidic Acid
Endocrinology,
June 1, 2004;
145(6):
2929 - 2940.
[Abstract][Full Text][PDF]
Y. Absenger, H. Hess-Stumpp, B. Kreft, J. Kratzschmar, B. Haendler, N. Schutze, P.-A. Regidor, and E. Winterhager Cyr61, a deregulated gene in endometriosis
Mol. Hum. Reprod.,
June 1, 2004;
10(6):
399 - 407.
[Abstract][Full Text][PDF]
E. M. Tam, C. J. Morrison, Y. I. Wu, M. S. Stack, and C. M. Overall Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates
PNAS,
May 4, 2004;
101(18):
6917 - 6922.
[Abstract][Full Text][PDF]
P. C. Trackman and A. Kantarci CONNECTIVE TISSUE METABOLISM AND GINGIVAL OVERGROWTH
Critical Reviews in Oral Biology & Medicine,
May 1, 2004;
15(3):
165 - 175.
[Abstract][Full Text][PDF]
A W Rachfal, M H Luquette, and D R Brigstock Expression of connective tissue growth factor (CCN2) in desmoplastic small round cell tumour
J. Clin. Pathol.,
April 1, 2004;
57(4):
422 - 425.
[Abstract][Full Text][PDF]
D. Xie, D. Yin, H.-J. Wang, G.-T. Liu, R. Elashoff, K. Black, and H. P. Koeffler Levels of Expression of CYR61 and CTGF Are Prognostic for Tumor Progression and Survival of Individuals with Gliomas
Clin. Cancer Res.,
March 15, 2004;
10(6):
2072 - 2081.
[Abstract][Full Text][PDF]
R. Gao and D. R. Brigstock Connective Tissue Growth Factor (CCN2) Induces Adhesion of Rat Activated Hepatic Stellate Cells by Binding of Its C-terminal Domain to Integrin {alpha}v{beta}3 and Heparan Sulfate Proteoglycan
J. Biol. Chem.,
March 5, 2004;
279(10):
8848 - 8855.
[Abstract][Full Text][PDF]
C.-C. Chang, J.-Y. Shih, Y.-M. Jeng, J.-L. Su, B.-Z. Lin, S.-T. Chen, Y.-P. Chau, P.-C. Yang, and M.-L. Kuo Connective Tissue Growth Factor and Its Role in Lung Adenocarcinoma Invasion and Metastasis
J Natl Cancer Inst,
March 3, 2004;
96(5):
364 - 375.
[Abstract][Full Text][PDF]
S. Croci, L. Landuzzi, A. Astolfi, G. Nicoletti, A. Rosolen, F. Sartori, M. Y. Follo, N. Oliver, C. De Giovanni, P. Nanni, et al. Inhibition of Connective Tissue Growth Factor (CTGF/CCN2) Expression Decreases the Survival and Myogenic Differentiation of Human Rhabdomyosarcoma Cells
Cancer Res.,
March 1, 2004;
64(5):
1730 - 1736.
[Abstract][Full Text][PDF]
M. Minato, S. Kubota, H. Kawaki, T. Nishida, A. Miyauchi, H. Hanagata, T. Nakanishi, T. Takano-Yamamoto, and M. Takigawa Module-Specific Antibodies against Human Connective Tissue Growth Factor: Utility for Structural and Functional Analysis of the Factor as Related to Chondrocytes
J. Biochem.,
March 1, 2004;
135(3):
347 - 354.
[Abstract][Full Text][PDF]
H. R. Mason, A. C. Lake, J. E. Wubben, R. A. Nowak, and J. J. Castellot Jr The growth arrest-specific gene CCN5 is deficient in human leiomyomas and inhibits the proliferation and motility of cultured human uterine smooth muscle cells
Mol. Hum. Reprod.,
March 1, 2004;
10(3):
181 - 187.
[Abstract][Full Text][PDF]
H. R. Mason, D. Grove-Strawser, B. S. Rubin, R. A. Nowak, and J. J. Castellot Jr. Estrogen Induces CCN5 Expression in the Rat Uterus in Vivo
Endocrinology,
February 1, 2004;
145(2):
976 - 982.
[Abstract][Full Text][PDF]
S. Sakamoto, M. Yokoyama, K. Prakash, J.-I. Tsuruha, S. Masamoto, R. H. Getzenberg, and Y. Kakehi Development of Quantitative Detection Assays for CYR61 as a New Marker for Benign Prostatic Hyperplasia
J Biomol Screen,
December 1, 2003;
8(6):
701 - 711.
[Abstract][PDF]
P. Bonniaud, P. J. Margetts, M. Kolb, T. Haberberger, M. Kelly, J. Robertson, and J. Gauldie Adenoviral Gene Transfer of Connective Tissue Growth Factor in the Lung Induces Transient Fibrosis
Am. J. Respir. Crit. Care Med.,
October 1, 2003;
168(7):
770 - 778.
[Abstract][Full Text][PDF]
G. Weston, A. C. Trajstman, C. E. Gargett, U. Manuelpillai, B. J. Vollenhoven, and P. A.W. Rogers Fibroids display an anti-angiogenic gene expression profile when compared with adjacent myometrium
Mol. Hum. Reprod.,
September 1, 2003;
9(9):
541 - 549.
[Abstract][Full Text][PDF]
Y. Liang, C. Li, V. M. Guzman, A. J. Evinger III, C. E. Protzman, A. H.-P. Krauss, and D. F. Woodward Comparison of Prostaglandin F2{alpha}, Bimatoprost (Prostamide), and Butaprost (EP2 Agonist) on Cyr61 and Connective Tissue Growth Factor Gene Expression
J. Biol. Chem.,
July 11, 2003;
278(29):
27267 - 27277.
[Abstract][Full Text][PDF]
J. M. Schober, L. F. Lau, T. P. Ugarova, and S. C.-T. Lam Identification of a Novel Integrin {alpha}M{beta}2 Binding Site in CCN1 (CYR61), a Matricellular Protein Expressed in Healing Wounds and Atherosclerotic Lesions
J. Biol. Chem.,
July 3, 2003;
278(28):
25808 - 25815.
[Abstract][Full Text][PDF]
S. WERNER and R. GROSE Regulation of Wound Healing by Growth Factors and Cytokines
Physiol Rev,
July 1, 2003;
83(3):
835 - 870.
[Abstract][Full Text][PDF]
P. Finckenberg, K. Inkinen, J. Ahonen, S. Merasto, M. Louhelainen, H. Vapaatalo, D. Muller, D. Ganten, F. Luft, and E. Mervaala Angiotensin II Induces Connective Tissue Growth Factor Gene Expression via Calcineurin-Dependent Pathways
Am. J. Pathol.,
July 1, 2003;
163(1):
355 - 366.
[Abstract][Full Text][PDF]
C. G. Lin, S.-J. Leu, N. Chen, C. M. Tebeau, S.-X. Lin, C.-Y. Yeung, and L. F. Lau CCN3 (NOV) Is a Novel Angiogenic Regulator of the CCN Protein Family
J. Biol. Chem.,
June 20, 2003;
278(26):
24200 - 24208.
[Abstract][Full Text][PDF]
K. Sawai, K. Mori, M. Mukoyama, A. Sugawara, T. Suganami, M. Koshikawa, K. Yahata, H. Makino, T. Nagae, Y. Fujinaga, et al. Angiogenic Protein Cyr61 is Expressed by Podocytes in Anti-Thy-1 Glomerulonephritis
J. Am. Soc. Nephrol.,
May 1, 2003;
14(5):
1154 - 1163.
[Abstract][Full Text][PDF]
K. H. Kim, Y. K. Min, J.-H. Baik, L. F. Lau, B. Chaqour, and K. C. Chung Expression of Angiogenic Factor Cyr61 during Neuronal Cell Death via the Activation of c-Jun N-terminal Kinase and Serum Response Factor
J. Biol. Chem.,
April 11, 2003;
278(16):
13847 - 13854.
[Abstract][Full Text][PDF]
A. Leask, A. Holmes, C. M. Black, and D. J. Abraham Connective Tissue Growth Factor Gene Regulation. REQUIREMENTS FOR ITS INDUCTION BY TRANSFORMING GROWTH FACTOR-beta 2 IN FIBROBLASTS
J. Biol. Chem.,
April 4, 2003;
278(15):
13008 - 13015.
[Abstract][Full Text][PDF]
B Perbal, D R Brigstock, and L F Lau Report on the second international workshop on the CCN family of genes
Mol. Pathol.,
April 1, 2003;
56(2):
80 - 85.
[Abstract][Full Text][PDF]
D R Brigstock, R Goldschmeding, K-i Katsube, S C-T Lam, L F Lau, K Lyons, C Naus, B Perbal, B Riser, M Takigawa, et al. Proposal for a unified CCN nomenclature
Mol. Pathol.,
April 1, 2003;
56(2):
127 - 128.
[Abstract][Full Text][PDF]
H. Thibout, C. Martinerie, C. Creminon, F. Godeau, P. Boudou, Y. Le Bouc, and M. Laurent Characterization of Human NOV in Biological Fluids: An Enzyme Immunoassay for the Quantification of Human NOV in Sera from Patients with Diseases of the Adrenal Gland and of the Nervous System
J. Clin. Endocrinol. Metab.,
January 1, 2003;
88(1):
327 - 336.
[Abstract][Full Text][PDF]
A. C. Lake, A. Bialik, K. Walsh, and J. J. Castellot Jr CCN5 Is a Growth Arrest-Specific Gene That Regulates Smooth Muscle Cell Proliferation and Motility
Am. J. Pathol.,
January 1, 2003;
162(1):
219 - 231.
[Abstract][Full Text][PDF]
F.-E Mo, A. G. Muntean, C.-C. Chen, D. B. Stolz, S. C. Watkins, and L. F. Lau CYR61 (CCN1) Is Essential for Placental Development and Vascular Integrity
Mol. Cell. Biol.,
December 15, 2002;
22(24):
8709 - 8720.
[Abstract][Full Text][PDF]
Y.-P. Cheon, Q. Li, X. Xu, F. J. DeMayo, I. C. Bagchi, and M. K. Bagchi A Genomic Approach to Identify Novel Progesterone Receptor Regulated Pathways in the Uterus during Implantation
Mol. Endocrinol.,
December 1, 2002;
16(12):
2853 - 2871.
[Abstract][Full Text][PDF]
S.-J. Leu, S. C.-T. Lam, and L. F. Lau Pro-angiogenic Activities of CYR61 (CCN1) Mediated through Integrins alpha vbeta 3 and alpha 6beta 1 in Human Umbilical Vein Endothelial Cells
J. Biol. Chem.,
November 22, 2002;
277(48):
46248 - 46255.
[Abstract][Full Text][PDF]
J. K. G. Crean, D. Finlay, M. Murphy, C. Moss, C. Godson, F. Martin, and H. R. Brady The Role of p42/44 MAPK and Protein Kinase B in Connective Tissue Growth Factor Induced Extracellular Matrix Protein Production, Cell Migration, and Actin Cytoskeletal Rearrangement in Human Mesangial Cells
J. Biol. Chem.,
November 8, 2002;
277(46):
44187 - 44194.
[Abstract][Full Text][PDF]
J. Lafont, M. Laurent, H. Thibout, F. Lallemand, Y. Le Bouc, A. Atfi, and C. Martinerie The Expression of novH in Adrenocortical Cells Is Down-regulated by TGFbeta 1 through c-Jun in a Smad-independent Manner
J. Biol. Chem.,
October 18, 2002;
277(43):
41220 - 41229.
[Abstract][Full Text][PDF]
B. Chaqour, C. Whitbeck, J.-S. Han, E. Macarak, P. Horan, P. Chichester, and R. Levin Cyr61 and CTGF are molecular markers of bladder wall remodeling after outlet obstruction
Am J Physiol Endocrinol Metab,
October 1, 2002;
283(4):
E765 - E774.
[Abstract][Full Text][PDF]
C. R. Harlow, L. Davidson, K. H. Burns, C. Yan, M. M. Matzuk, and S. G. Hillier FSH and TGF-{beta} Superfamily Members Regulate Granulosa Cell Connective Tissue Growth Factor Gene Expression in Vitro and in Vivo
Endocrinology,
September 1, 2002;
143(9):
3316 - 3325.
[Abstract][Full Text][PDF]
K. J. Way, K. Isshiki, K. Suzuma, T. Yokota, D. Zvagelsky, F. J. Schoen, G. E. Sandusky, P. A. Pechous, C. J. Vlahos, H. Wakasaki, et al. Expression of Connective Tissue Growth Factor Is Increased in Injured Myocardium Associated With Protein Kinase C {beta}2 Activation and Diabetes
Diabetes,
September 1, 2002;
51(9):
2709 - 2718.
[Abstract][Full Text][PDF]
K. Sakamoto, S. Yamaguchi, R. Ando, A. Miyawaki, Y. Kabasawa, M. Takagi, C. L. Li, B. Perbal, and K.-i. Katsube The Nephroblastoma Overexpressed Gene (NOV/ccn3) Protein Associates with Notch1 Extracellular Domain and Inhibits Myoblast Differentiation via Notch Signaling Pathway
J. Biol. Chem.,
August 9, 2002;
277(33):
29399 - 29405.
[Abstract][Full Text][PDF]
C L Li, V Martinez, B He, A Lombet, and B Perbal A role for CCN3 (NOV) in calcium signalling
Mol. Pathol.,
August 1, 2002;
55(4):
250 - 261.
[Abstract][Full Text][PDF]
E E-D A Moussad, M A E Rageh, A K Wilson, R D Geisert, and D R Brigstock Temporal and spatial expression of connective tissue growth factor (CCN2; CTGF) and transforming growth factor {beta} type 1 (TGF-{beta}1) at the utero-placental interface during early pregnancy in the pig
Mol. Pathol.,
June 1, 2002;
55(3):
186 - 192.
[Abstract][Full Text][PDF]
J. M. Schober, N. Chen, T. M. Grzeszkiewicz, I. Jovanovic, E. E. Emeson, T. P. Ugarova, R. D. Ye, L. F. Lau, and S. C.-T. Lam Identification of integrin alpha Mbeta 2 as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions
Blood,
May 29, 2002;
99(12):
4457 - 4465.
[Abstract][Full Text][PDF]
S. Kondo, S. Kubota, T. Shimo, T. Nishida, G. Yosimichi, T. Eguchi, T. Sugahara, and M. Takigawa Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases
Carcinogenesis,
May 1, 2002;
23(5):
769 - 776.
[Abstract][Full Text][PDF]
T. M. Grzeszkiewicz, V. Lindner, N. Chen, S. C.-T. Lam, and L. F. Lau The Angiogenic Factor Cysteine-Rich 61 (CYR61, CCN1) Supports Vascular Smooth Muscle Cell Adhesion and Stimulates Chemotaxis through Integrin {alpha}6{beta}1 and Cell Surface Heparan Sulfate Proteoglycans
Endocrinology,
April 1, 2002;
143(4):
1441 - 1450.
[Abstract][Full Text][PDF]
M. C. Manara, B. Perbal, S. Benini, R. Strammiello, V. Cerisano, S. Perdichizzi, M. Serra, A. Astolfi, F. Bertoni, J. Alami, et al. The Expression of ccn3(nov) Gene in Musculoskeletal Tumors
Am. J. Pathol.,
March 1, 2002;
160(3):
849 - 859.
[Abstract][Full Text][PDF]
J. Liu, V.-M. Kosma, T. Vanttinen, C. Hyden-Granskog, and R. Voutilainen Gonadotrophins inhibit the expression of insulin-like growth factor binding protein-related protein-2 mRNA in cultured human granulosa-luteal cells
Mol. Hum. Reprod.,
February 1, 2002;
8(2):
136 - 141.
[Abstract][Full Text][PDF]
F. Su, M. Overholtzer, D. Besser, and A. J. Levine WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase
Genes & Dev.,
January 1, 2002;
16(1):
46 - 57.
[Abstract][Full Text][PDF]
C.-C. Chen, F.-E Mo, and L. F. Lau The Angiogenic Factor Cyr61 Activates a Genetic Program for Wound Healing in Human Skin Fibroblasts
J. Biol. Chem.,
December 7, 2001;
276(50):
47329 - 47337.
[Abstract][Full Text][PDF]