Department of Endocrinology, St. Bartholomew’s Hospital, London
EC1A 7BE, United Kingdom
I. Introduction
A. Origin of tumors: hypothalamus vs. pituitary
B. Clonality of pituitary tumors
II. Protooncogenes
III.Tumor Suppressor Genes
A. p53
B. p16/CDKN2/MTS1/INK4 andRb1
C. p27/KIP1/CDKN4
D. MEN1
E. hZAC
F. NM23
G. Othertumor suppressor genes
IV. Specific Genes
A. Regulatoryreceptor genes
B. Cytokines and growth factors
C. Developmentalgenes
V. Miscellaneous
A. Other genes
B. Methylation
VI.Perspectives: Old and New Tools for Understanding Pituitary
Pathogenesis
A. Transgenic/knockout animal models
VII. Conclusions
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