help button home button Endocrine Society Endocrine Reviews
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Aguilar-Bryan, L.
Right arrow Articles by Bryan, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Aguilar-Bryan, L.
Right arrow Articles by Bryan, J.
Endocrine Reviews 20 (2): 101-135
Copyright © 1999 by The Endocrine Society

Molecular Biology of Adenosine Triphosphate-Sensitive Potassium Channels1

Lydia Aguilar-Bryan and Joseph Bryan

Departments of Medicine (L.A.-B.) and Cell Biology (J.B.), Baylor College of Medicine, Houston, Texas 77030

I. Introduction
II. How Are KATP Channels Defined?
III. How Do KATP Channels Affect the Membrane Potential of Pancreatic ß-Cells?
IV. KATP Channel Subunits
A. The KIR family of inwardly rectifying K+ channels
B. Sulfonylurea receptors
V. Reconstitution of KATP Channel Activity from SUR1 and KIR6.2
A. The question of "promiscuous coupling" of SUR1 with other inward rectifiers
VI. KATP Channel Structure
A. KIR6.2 forms the pore of a KATP channel
B. SUR1 and KIR6.x are physically associated
C. Coexpression with KIR6.2 affects the maturation of SUR1
D. Complex glycosylated SUR1 and KIR6.2 assemble a large multimer
E. A 1:1 stoichiometry of SUR to KIR is both necessary and sufficient to make KATP channels
F. Other KIR channels are tetramers
G. The stoichiometry of active ß-cell KATP channels is (SUR1/KIR6.2)4
VII. Regulation of KATP Channel Activity
A. How do ATP and ADP exert their effects on KATP channels?
B. Where are the nucleotide binding sites located?
C. C-terminally truncated KIR6.2 channels show abnormal kinetics
D. Coexpression of KIR6.2{Delta}C subunits with SUR restores normal KATP channel activity
E. Why are KIR6.2 channels silent?
F. The N terminus of KIR6.2 limits burst duration
G. Where do the openers bind and how do they work?
H. Do SURs have adenosine triphosphatase (ATPase) activity?
I. Do SURs have transport activity?
J. Is there an endogenous substrate?
VIII. Human SUR1 and KIR6.2 Genes
IX. KATP Channels and Persistent Hyperinsulinemic Hypoglycemia of Infancy (PHHI)
A. HI-GK
B. HI-GlnDH
C. HI-"unknown"
D. HI-KIR6.2
E. HI-SUR1
X. Linking PHHI to Defects in KATP Channel Activity
A. ß-Cells from newborns diagnosed with "sporadic" PHHI lack KATP channel activity
B. PHHI ß-cells with the SUR1 exon 35 mutation lack KATP channel activity
C. Why is there a lack of dominant negative mutations?
D. Development of mouse models
XI. Other Issues
A. Nesidioblastosis does not cause PHHI
B. "Diffuse" vs. "focal" forms of PHHI
XII. KATP and Non-Insulin-Dependent Diabetes Mellitus (NIDDM)
A. ß-Cell type KATP channels in the brain
XIII. The Leptin Connection
XIV. Summary and Conclusions




This article has been cited by other articles:


Home page
HypertensionHome page
J. Jiao, V. Garg, B. Yang, T. S. Elton, and K. Hu
Protein Kinase C-{epsilon} Induces Caveolin-Dependent Internalization of Vascular Adenosine 5'-Triphosphate-Sensitive K+ Channels
Hypertension, September 1, 2008; 52(3): 499 - 506.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
N. J. Webster, G. J. Searle, P. P. L. Lam, Y.-C. Huang, M. J. Riedel, G. Harb, H. Y. Gaisano, A. Holt, and P. E. Light
Elevation in Intracellular Long-Chain Acyl-Coenzyme A Esters Lead to Reduced {beta}-Cell Excitability via Activation of Adenosine 5'-Triphosphate-Sensitive Potassium Channels
Endocrinology, July 1, 2008; 149(7): 3679 - 3687.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
M. Abdulhadi-Atwan, J. D. Bushman, S. Tornovsky-Babaey, A. Perry, A. Abu-Libdeh, B. Glaser, S.-L. Shyng, and D. H. Zangen
Novel De Novo Mutation in Sulfonylurea Receptor 1 Presenting as Hyperinsulinism in Infancy Followed by Overt Diabetes in Early Adolescence
Diabetes, July 1, 2008; 57(7): 1935 - 1940.
[Abstract] [Full Text] [PDF]


Home page
Endocr. Rev.Home page
L. Aguilar-Bryan and J. Bryan
Neonatal Diabetes Mellitus
Endocr. Rev., May 1, 2008; 29(3): 265 - 291.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
W. Huang, M. Acosta-Martinez, and J. E. Levine
Ovarian Steroids Stimulate Adenosine Triphosphate-Sensitive Potassium (KATP) Channel Subunit Gene Expression and Confer Responsiveness of the Gonadotropin-Releasing Hormone Pulse Generator to KATP Channel Modulation
Endocrinology, May 1, 2008; 149(5): 2423 - 2432.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
Y.-W. Lin, J. D. Bushman, F.-F. Yan, S. Haidar, C. MacMullen, A. Ganguly, C. A. Stanley, and S.-L. Shyng
Destabilization of ATP-sensitive Potassium Channel Activity by Novel KCNJ11 Mutations Identified in Congenital Hyperinsulinism
J. Biol. Chem., April 4, 2008; 283(14): 9146 - 9156.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
J.-D. Jiao, V. Garg, B. Yang, and K. Hu
Novel functional role of heat shock protein 90 in ATP-sensitive K+ channel-mediated hypoxic preconditioning
Cardiovasc Res, January 1, 2008; 77(1): 126 - 133.
[Abstract] [Full Text] [PDF]


Home page
J. Gen. Physiol.Home page
K. W. Chan, A. Wheeler, and L. Csanady
Sulfonylurea Receptors Type 1 and 2A Randomly Assemble to Form Heteromeric KATP Channels of Mixed Subunit Composition
J. Gen. Physiol., December 31, 2007; 131(1): 43 - 58.
[Abstract] [Full Text] [PDF]


Home page
Endocr. Rev.Home page
Y. M. Leung, E. P. Kwan, B. Ng, Y. Kang, and H. Y. Gaisano
SNAREing Voltage-Gated K+ and ATP-Sensitive K+ Channels: Tuning {beta}-Cell Excitability with Syntaxin-1A and Other Exocytotic Proteins
Endocr. Rev., October 1, 2007; 28(6): 653 - 663.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
F.-F. Yan, Y.-W. Lin, C. MacMullen, A. Ganguly, C. A. Stanley, and S.-L. Shyng
Congenital Hyperinsulinism Associated ABCC8 Mutations That Cause Defective Trafficking of ATP-Sensitive K+ Channels: Identification and Rescue
Diabetes, September 1, 2007; 56(9): 2339 - 2348.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
K. Dezaki, M. Kakei, and T. Yada
Ghrelin Uses G{alpha}i2 and Activates Voltage-Dependent K+ Channels to Attenuate Glucose-Induced Ca2+ Signaling and Insulin Release in Islet {beta}-Cells: Novel Signal Transduction of Ghrelin
Diabetes, September 1, 2007; 56(9): 2319 - 2327.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Y. Shi, Z. Wu, N. Cui, W. Shi, Y. Yang, X. Zhang, A. Rojas, B. T. Ha, and C. Jiang
PKA phosphorylation of SUR2B subunit underscores vascular KATP channel activation by beta-adrenergic receptors
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1205 - R1214.
[Abstract] [Full Text] [PDF]


Home page
J. Pharmacol. Exp. Ther.Home page
M. Winkler, D. Stephan, S. Bieger, P. Kuhner, F. Wolff, and U. Quast
Testing the Bipartite Model of the Sulfonylurea Receptor Binding Site: Binding of A-, B-, and A + B-Site Ligands
J. Pharmacol. Exp. Ther., August 1, 2007; 322(2): 701 - 708.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
N. Baroukh, M. A. Ravier, M. K. Loder, E. V. Hill, A. Bounacer, R. Scharfmann, G. A. Rutter, and E. Van Obberghen
MicroRNA-124a Regulates Foxa2 Expression and Intracellular Signaling in Pancreatic beta-Cell Lines
J. Biol. Chem., July 6, 2007; 282(27): 19575 - 19588.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
V. Garg and K. Hu
Protein kinase C isoform-dependent modulation of ATP-sensitive K+ channels in mitochondrial inner membrane
Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H322 - H332.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
M. Vaxillaire, A. Dechaume, K. Busiah, H. Cave, S. Pereira, R. Scharfmann, G. P. de Nanclares, L. Castano, P. Froguel, M. Polak, et al.
New ABCC8 Mutations in Relapsing Neonatal Diabetes and Clinical Features
Diabetes, June 1, 2007; 56(6): 1737 - 1741.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
X. Mao, Y. Chai, and Y.-F. Lin
Dual regulation of the ATP-sensitive potassium channel by caffeine
Am J Physiol Cell Physiol, June 1, 2007; 292(6): C2239 - C2258.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
M. Acosta-Martinez and J. E. Levine
Regulation of KATP channel subunit gene expression by hyperglycemia in the mediobasal hypothalamus of female rats
Am J Physiol Endocrinol Metab, June 1, 2007; 292(6): E1801 - E1807.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
A. Szollosi, M. Nenquin, and J.-C. Henquin
Overnight Culture Unmasks Glucose-induced Insulin Secretion in Mouse Islets Lacking ATP-sensitive K+ Channels by Improving the Triggering Ca2+ Signal
J. Biol. Chem., May 18, 2007; 282(20): 14768 - 14776.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
A. Hambrock, C. B. de Oliveira Franz, S. Hiller, A. Grenz, S. Ackermann, D. U. Schulze, G. Drews, and H. Osswald
Resveratrol Binds to the Sulfonylurea Receptor (SUR) and Induces Apoptosis in a SUR Subtype-specific Manner
J. Biol. Chem., February 2, 2007; 282(5): 3347 - 3356.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
A. Szollosi, M. Nenquin, L. Aguilar-Bryan, J. Bryan, and J.-C. Henquin
Glucose Stimulates Ca2+ Influx and Insulin Secretion in 2-Week-old beta-Cells Lacking ATP-sensitive K+ Channels
J. Biol. Chem., January 19, 2007; 282(3): 1747 - 1756.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
F.-F. Yan, J. Casey, and S.-L. Shyng
Sulfonylureas Correct Trafficking Defects of Disease-causing ATP-sensitive Potassium Channels by Binding to the Channel Complex
J. Biol. Chem., November 3, 2006; 281(44): 33403 - 33413.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
K. Heusser, H. Yuan, I. Neagoe, A. I. Tarasov, F. M. Ashcroft, and B. Schwappach
Scavenging of 14-3-3 proteins reveals their involvement in the cell-surface transport of ATP-sensitive K+ channels
J. Cell Sci., October 15, 2006; 119(20): 4353 - 4363.
[Abstract] [Full Text] [PDF]


Home page
J. Physiol.Home page
K. Fang, L. Csanady, and K. W. Chan
The N-terminal transmembrane domain (TMD0) and a cytosolic linker (L0) of sulphonylurea receptor define the unique intrinsic gating of KATP channels
J. Physiol., October 15, 2006; 576(2): 379 - 389.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
N. M. Doliba, W. Qin, M. Z. Vatamaniuk, C. W. Buettger, H. W. Collins, M. A Magnuson, K. H. Kaestner, D. F. Wilson, R. D. Carr, and F. M. Matschinsky
Cholinergic regulation of fuel-induced hormone secretion and respiration of SUR1-/- mouse islets
Am J Physiol Endocrinol Metab, September 1, 2006; 291(3): E525 - E535.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
P. Stiernet, Y. Guiot, P. Gilon, and J.-C. Henquin
Glucose Acutely Decreases pH of Secretory Granules in Mouse Pancreatic Islets: MECHANISMS AND INFLUENCE ON INSULIN SECRETION
J. Biol. Chem., August 4, 2006; 281(31): 22142 - 22151.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
N. Yokoi, M. Kanamori, Y. Horikawa, J. Takeda, T. Sanke, H. Furuta, K. Nanjo, H. Mori, M. Kasuga, K. Hara, et al.
Association Studies of Variants in the Genes Involved in Pancreatic {beta}-Cell Function in Type 2 Diabetes in Japanese Subjects.
Diabetes, August 1, 2006; 55(8): 2379 - 2386.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
C.-W. Lin, Y.-W. Lin, F.-F. Yan, J. Casey, M. Kochhar, E. B. Pratt, and S.-L. Shyng
Kir6.2 Mutations Associated With Neonatal Diabetes Reduce Expression of ATP-Sensitive K+ channels: Implications in Disease Mechanism and Sulfonylurea Therapy
Diabetes, June 1, 2006; 55(6): 1738 - 1746.
[Abstract] [Full Text] [PDF]


Home page
Diabetes CareHome page
Z. T. Bloomgarden
Cardiovascular Disease
Diabetes Care, May 1, 2006; 29(5): 1160 - 1166.
[Full Text] [PDF]


Home page
EndocrinologyHome page
Y. M. Leung, I. Ahmed, L. Sheu, X. Gao, M. Hara, R. G. Tsushima, N. E. Diamant, and H. Y. Gaisano
Insulin Regulates Islet {alpha}-Cell Function by Reducing KATP Channel Sensitivity to Adenosine 5'-Triphosphate Inhibition
Endocrinology, May 1, 2006; 147(5): 2155 - 2162.
[Abstract] [Full Text] [PDF]


Home page
J. Physiol.Home page
N. Teramoto
Physiological roles of ATP-sensitive K+ channels in smooth muscle
J. Physiol., May 1, 2006; 572(3): 617 - 624.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
A. V. Gyulkhandanyan, S. C. Lee, G. Bikopoulos, F. Dai, and M. B. Wheeler
The Zn2+-transporting Pathways in Pancreatic beta-Cells: A ROLE FOR THE L-TYPE VOLTAGE-GATED Ca2+ CHANNEL
J. Biol. Chem., April 7, 2006; 281(14): 9361 - 9372.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
N. Ishiyama, M. A. Ravier, and J.-C. Henquin
Dual mechanism of the potentiation by glucose of insulin secretion induced by arginine and tolbutamide in mouse islets
Am J Physiol Endocrinol Metab, March 1, 2006; 290(3): E540 - E549.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
Y.-W. Lin, C. MacMullen, A. Ganguly, C. A. Stanley, and S.-L. Shyng
A Novel KCNJ11 Mutation Associated with Congenital Hyperinsulinism Reduces the Intrinsic Open Probability of beta-Cell ATP-sensitive Potassium Channels
J. Biol. Chem., February 3, 2006; 281(5): 3006 - 3012.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
T. Otonkoski, K. Nanto-Salonen, M. Seppanen, R. Veijola, H. Huopio, K. Hussain, P. Tapanainen, O. Eskola, R. Parkkola, K. Ekstrom, et al.
Noninvasive Diagnosis of Focal Hyperinsulinism of Infancy With [18F]-DOPA Positron Emission Tomography
Diabetes, January 1, 2006; 55(1): 13 - 18.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
A. Munoz, M. Hu, K. Hussain, J. Bryan, L. Aguilar-Bryan, and A. S. Rajan
Regulation of Glucagon Secretion at Low Glucose Concentrations: Evidence for Adenosine Triphosphate-Sensitive Potassium Channel Involvement
Endocrinology, December 1, 2005; 146(12): 5514 - 5521.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
L. R. Conti and C. A. Vandenberg
ERADication of ion channels destined for the plasma membrane. Focus on "Role of ubiquitin-proteasome degradation pathway in biogenesis efficiency of {beta}-cell ATP-sensitive potassium channels"
Am J Physiol Cell Physiol, November 1, 2005; 289(5): C1072 - C1074.
[Full Text] [PDF]


Home page
DiabetesHome page
J. C. Koster, M. A. Permutt, and C. G. Nichols
Diabetes and Insulin Secretion: The ATP-Sensitive K+ Channel (KATP) Connection
Diabetes, November 1, 2005; 54(11): 3065 - 3072.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
F.-F. Yan, C.-W. Lin, E. A. Cartier, and S.-L. Shyng
Role of ubiquitin-proteasome degradation pathway in biogenesis efficiency of {beta}-cell ATP-sensitive potassium channels
Am J Physiol Cell Physiol, November 1, 2005; 289(5): C1351 - C1359.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
C.-W. Lin, F. Yan, S. Shimamura, S. Barg, and S.-L. Shyng
Membrane Phosphoinositides Control Insulin Secretion Through Their Effects on ATP-Sensitive K+ Channel Activity
Diabetes, October 1, 2005; 54(10): 2852 - 2858.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
H. Heissig, K. A. Urban, K. Hastedt, B. J. Zunkler, and U. Panten
Mechanism of the Insulin-Releasing Action of {alpha}-Ketoisocaproate and Related {alpha}-Keto Acid Anions
Mol. Pharmacol., October 1, 2005; 68(4): 1097 - 1105.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
C. Shiota, J. V. Rocheleau, M. Shiota, D. W. Piston, and M. A. Magnuson
Impaired glucagon secretory responses in mice lacking the type 1 sulfonylurea receptor
Am J Physiol Endocrinol Metab, October 1, 2005; 289(4): E570 - E577.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
E. Marthinet, A. Bloc, Y. Oka, Y. Tanizawa, B. Wehrle-Haller, V. Bancila, J.-M. Dubuis, J. Philippe, and V. M. Schwitzgebel
Severe Congenital Hyperinsulinism Caused by a Mutation in the Kir6.2 Subunit of the Adenosine Triphosphate-Sensitive Potassium Channel Impairing Trafficking and Function
J. Clin. Endocrinol. Metab., September 1, 2005; 90(9): 5401 - 5406.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
R. Cruz-Cruz, A. Salgado, C. Sanchez-Soto, L. Vaca, and M. Hiriart
Thapsigargin-sensitive cationic current leads to membrane depolarization, calcium entry, and insulin secretion in rat pancreatic {beta}-cells
Am J Physiol Endocrinol Metab, September 1, 2005; 289(3): E439 - E445.
[Abstract] [Full Text] [PDF]


Home page
J. Gen. Physiol.Home page
L. Li, X. Geng, M. Yonkunas, A. Su, E. Densmore, P. Tang, and P. Drain
Ligand-dependent Linkage of the ATP Site to Inhibition Gate Closure in the KATP Channel
J. Gen. Physiol., August 29, 2005; 126(3): 285 - 299.
[Abstract] [Full Text] [PDF]


Home page
Endocr. Rev.Home page
S. J. Marx and W. F. Simonds
Hereditary Hormone Excess: Genes, Molecular Pathways, and Syndromes
Endocr. Rev., August 1, 2005; 26(5): 615 - 661.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
M. A. Ravier and G. A. Rutter
Glucose or Insulin, but not Zinc Ions, Inhibit Glucagon Secretion From Mouse Pancreatic {alpha}-Cells
Diabetes, June 1, 2005; 54(6): 1789 - 1797.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
S. Ullrich, S. Berchtold, F. Ranta, G. Seebohm, G. Henke, A. Lupescu, A. F. Mack, C.-M. Chao, J. Su, R. Nitschke, et al.
Serum- and Glucocorticoid-Inducible Kinase 1 (SGK1) Mediates Glucocorticoid-Induced Inhibition of Insulin Secretion
Diabetes, April 1, 2005; 54(4): 1090 - 1099.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
V. Bancila, T. Cens, D. Monnier, F. Chanson, C. Faure, Y. Dunant, and A. Bloc
Two SUR1-specific Histidine Residues Mandatory for Zinc-induced Activation of the Rat KATP Channel
J. Biol. Chem., March 11, 2005; 280(10): 8793 - 8799.
[Abstract] [Full Text] [PDF]


Home page
J. Physiol.Home page
E. Sharifullina, K. Ostroumov, and A. Nistri
Metabotropic glutamate receptor activity induces a novel oscillatory pattern in neonatal rat hypoglossal motoneurones
J. Physiol., February 15, 2005; 563(1): 139 - 159.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
B. Raju and P. E. Cryer
Mechanism, temporal patterns, and magnitudes of the metabolic responses to the KATP channel agonist diazoxide
Am J Physiol Endocrinol Metab, January 1, 2005; 288(1): E80 - E85.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
D. Ye, W. Zhou, and H.-C. Lee
Activation of rat mesenteric arterial KATP channels by 11,12-epoxyeicosatrienoic acid
Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H358 - H364.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
S. Tornovsky, A. Crane, K. E. Cosgrove, K. Hussain, J. Lavie, M. Heyman, Y. Nesher, N. Kuchinski, E. Ben-Shushan, O. Shatz, et al.
Hyperinsulinism of Infancy: Novel ABCC8 and KCNJ11 Mutations and Evidence for Additional Locus Heterogeneity
J. Clin. Endocrinol. Metab., December 1, 2004; 89(12): 6224 - 6234.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
J.-C. Henquin
Pathways in Beta-Cell Stimulus-Secretion Coupling as Targets for Therapeutic Insulin Secretagogues
Diabetes, December 1, 2004; 53(suppl_3): S48 - S58.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
J. Bryan, W. H. Vila-Carriles, G. Zhao, A. P. Babenko, and L. Aguilar-Bryan
Toward Linking Structure With Function in ATP-Sensitive K+ Channels
Diabetes, December 1, 2004; 53(suppl_3): S104 - S112.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
U. Quast, D. Stephan, S. Bieger, and U. Russ
The Impact of ATP-Sensitive K+ Channel Subtype Selectivity of Insulin Secretagogues for the Coronary Vasculature and the Myocardium
Diabetes, December 1, 2004; 53(suppl_3): S156 - S164.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
M. Anello, D. Spampinato, S. Piro, F. Purrello, and A. M. Rabuazzo
Glucosamine-induced alterations of mitochondrial function in pancreatic {beta}-cells: possible role of protein glycosylation
Am J Physiol Endocrinol Metab, October 1, 2004; 287(4): E602 - E608.
[Abstract] [Full Text] [PDF]


Home page
J. Exp. Biol.Home page
K. Ballanyi
Protective role of neuronal KATP channels in brain hypoxia
J. Exp. Biol., August 15, 2004; 207(18): 3201 - 3212.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
L. van Bever, S. Poitry, C. Faure, R. I. Norman, A. Roatti, and A. J. Baertschi
Pore loop-mutated rat KIR6.1 and KIR6.2 suppress KATP current in rat cardiomyocytes
Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H850 - H859.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
M. Nenquin, A. Szollosi, L. Aguilar-Bryan, J. Bryan, and J.-C. Henquin
Both Triggering and Amplifying Pathways Contribute to Fuel-induced Insulin Secretion in the Ab