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Modulation of Gonadotropin Levels by Peptides Acting at the Anterior Pituitary Gland

University Department of Obstetrics and Gynaecology, Christchurch School of Medicine, Christchurch, New Zealand

I. Introduction

II. Between the Hypothalamus and the Pituitary

III. Direct Modulatory Action by Peptides

IV. Pituitary Receptors

V. Interaction of Peptides with GnRH

VI. Self-Priming by GnRH and Desensitization

A. The effect of peptides on the GnRH-primed LH response

B. The effect of peptides on the desensitized LH response to GnRH

VII. Steroids and the Ovulatory Cycle and the Effects on Peptide Characteristics

VIII. Intrapituitary Peptides

IX. Activity of Peptides in Vivo

X. Interaction Among non-GnRH Peptides

XI. Processes Other Than Secretion That Are Modulated by Peptides

XII. Summary and Conclusion

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