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Endocrine Reviews, doi:10.1210/edrv-2-3-264
Endocrine Reviews 2 (3): 264-274
Copyright © 1981 by The Endocrine Society
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Vitamin D and Pregnancy: The Maternal-Fetal Metabolism of Vitamin D

T. KENNEY GRAY*, WILLIAM LOWE and GAYLE E. LESTER*

Departments of Medicine and Pharmacology, University of North Carolina School of Medicine Chapel Hill, North Carolina 27514
Department of Medicine, Beth-Israel Hospital Boston, Massachusetts 02215

Correspondence: Address requests for reprints to: Dr. T. Kenney Gray, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27514.

Abstract

Pregnancy is associated with alterations in mineral metabolism and its hormonal regulation. Examples of these alterations include a positive calcium (Ca) balance, the increased absorption of Ca by the small intestine, and elevations in the serum level of parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D (1–4). The mechanisms underlying these alterations are not clearly defined and their interrelationships are largely unknown. This review will focus on the metabolism of vitamin D during pregnancy and will present information derived from human and nonhuman experimental studies. Several excellent reviews of vitamin D metabolism in the nonpregnant state are available to the reader (5–7), including one recently published in this journal (7). The topics of neonatal mineral metabolism and lactation that are related to the focus of this review have been reviewed comprehensively by others (8–10) and will not be included here except where they facilitate the exposition of vitamin D metabolism during pregnancy.

Footnotes

* Partly supported by NIH Grant HD-13547-02 and March of Dimes Birth Defects Foundation Grant 1-616.




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Copyright © 1981 by The Endocrine Society