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Autoimmune Disease Unit, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, and the University of California, Los Angeles, California 90048
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S. A. Morshed, R. Latif, and T. F. Davies Characterization of Thyrotropin Receptor Antibody-Induced Signaling Cascades Endocrinology, January 1, 2009; 150(1): 519 - 529. [Abstract] [Full Text] [PDF] |
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R Nunez Miguel, J Sanders, D Y Chirgadze, T L Blundell, J Furmaniak, and B Rees Smith FSH and TSH binding to their respective receptors: similarities, differences and implication for glycoprotein hormone specificity J. Mol. Endocrinol., September 1, 2008; 41(3): 145 - 164. [Abstract] [Full Text] [PDF] |
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C.-R. Chen, S. M. McLachlan, and B. Rapoport Identification of Key Amino Acid Residues in a Thyrotropin Receptor Monoclonal Antibody Epitope Provides Insight into Its Inverse Agonist and Antagonist Properties Endocrinology, July 1, 2008; 149(7): 3427 - 3434. [Abstract] [Full Text] [PDF] |
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Y. Mizutori, C.-R. Chen, S. M. McLachlan, and B. Rapoport The Thyrotropin Receptor Hinge Region Is Not Simply a Scaffold for the Leucine-Rich Domain but Contributes to Ligand Binding and Signal Transduction Mol. Endocrinol., May 1, 2008; 22(5): 1171 - 1182. [Abstract] [Full Text] [PDF] |
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O. Saitoh, N. Abiru, M. Nakahara, and Y. Nagayama CD8+CD122+ T Cells, a Newly Identified Regulatory T Subset, Negatively Regulate Graves' Hyperthyroidism in a Murine Model Endocrinology, December 1, 2007; 148(12): 6040 - 6046. [Abstract] [Full Text] [PDF] |
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S. M. McLachlan, Y. Nagayama, P. N. Pichurin, Y. Mizutori, C.-R. Chen, A. Misharin, H. A. Aliesky, and B. Rapoport The Link between Graves' Disease and Hashimoto's Thyroiditis: A Role for Regulatory T Cells Endocrinology, December 1, 2007; 148(12): 5724 - 5733. [Abstract] [Full Text] [PDF] |
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T. Ando, R. Latif, and T. F Davies Antibody-induced modulation of TSH receptor post-translational processing J. Endocrinol., October 1, 2007; 195(1): 179 - 186. [Abstract] [Full Text] [PDF] |
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R. Latif, T. Ando, and T. F. Davies Lipid Rafts Are Triage Centers for Multimeric and Monomeric Thyrotropin Receptor Regulation Endocrinology, July 1, 2007; 148(7): 3164 - 3175. [Abstract] [Full Text] [PDF] |
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T. Kaneda, A. Honda, A. Hakozaki, T. Fuse, A. Muto, and T. Yoshida An Improved Graves' Disease Model Established by Using in Vivo Electroporation Exhibited Long-Term Immunity to Hyperthyroidism in BALB/c Mice Endocrinology, May 1, 2007; 148(5): 2335 - 2344. [Abstract] [Full Text] [PDF] |
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C.-R. Chen, S. M. McLachlan, and B. Rapoport Suppression of Thyrotropin Receptor Constitutive Activity by a Monoclonal Antibody with Inverse Agonist Activity Endocrinology, May 1, 2007; 148(5): 2375 - 2382. [Abstract] [Full Text] [PDF] |
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N. G. Morgenthaler, S. C. Ho, and W. B. Minich Stimulating and Blocking Thyroid-Stimulating Hormone (TSH) Receptor Autoantibodies from Patients with Graves' Disease and Autoimmune Hypothyroidism Have Very Similar Concentration, TSH Receptor Affinity, and Binding Sites J. Clin. Endocrinol. Metab., March 1, 2007; 92(3): 1058 - 1065. [Abstract] [Full Text] [PDF] |
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P. Nurwakagari, A. Breit, C. Hess, H. Salman-Livny, D. Ben-Menahem, and T. Gudermann A conformational contribution of the luteinizing hormone-receptor ectodomain to receptor activation J. Mol. Endocrinol., February 1, 2007; 38(2): 259 - 275. [Abstract] [Full Text] [PDF] |
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G. Kleinau, M. Brehm, U. Wiedemann, D. Labudde, U. Leser, and G. Krause Implications for Molecular Mechanisms of Glycoprotein Hormone Receptors Using a New Sequence-Structure-Function Analysis Resource Mol. Endocrinol., February 1, 2007; 21(2): 574 - 580. [Abstract] [Full Text] [PDF] |
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M. Bonomi, M. Busnelli, L. Persani, G. Vassart, and S. Costagliola Structural Differences in the Hinge Region of the Glycoprotein Hormone Receptors: Evidence from the Sulfated Tyrosine Residues Mol. Endocrinol., December 1, 2006; 20(12): 3351 - 3363. [Abstract] [Full Text] [PDF] |
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S. Mueller, G. Kleinau, H. Jaeschke, S. Neumann, G. Krause, and R. Paschke Significance of Ectodomain Cysteine Boxes 2 and 3 for the Activation Mechanism of the Thyroid-stimulating Hormone Receptor J. Biol. Chem., October 20, 2006; 281(42): 31638 - 31646. [Abstract] [Full Text] [PDF] |
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J. A. Gilbert, S. L. Kalled, J. Moorhead, D. M. Hess, P. Rennert, Z. Li, M. Z. Khan, and J. P. Banga Treatment of Autoimmune Hyperthyroidism in a Murine Model of Graves' Disease with Tumor Necrosis Factor-Family Ligand Inhibitors Suggests a Key Role for B Cell Activating Factor in Disease Pathology Endocrinology, October 1, 2006; 147(10): 4561 - 4568. [Abstract] [Full Text] [PDF] |
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O. F. Lai, N. Zaiden, S. S. Goh, N.-E. Mohamed, L. L. Seah, K. S. Fong, V. Estienne, P. Carayon, S. C. Ho, and D. H C Khoo Detection of thyroid peroxidase mRNA and protein in orbital tissue. Eur. J. Endocrinol., August 1, 2006; 155(2): 213 - 218. [Abstract] [Full Text] [PDF] |
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O. Saitoh and Y. Nagayama Regulation of Graves' Hyperthyroidism with Naturally Occurring CD4+CD25+ Regulatory T Cells in a Mouse Model Endocrinology, May 1, 2006; 147(5): 2417 - 2422. [Abstract] [Full Text] [PDF] |
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J. A. Gilbert, A. G. Gianoukakis, S. Salehi, J. Moorhead, P. V. Rao, M. Z. Khan, A. M. McGregor, T. J. Smith, and J. P. Banga Monoclonal pathogenic antibodies to the thyroid-stimulating hormone receptor in Graves' disease with potent thyroid-stimulating activity but differential blocking activity activate multiple signaling pathways. J. Immunol., April 15, 2006; 176(8): 5084 - 5092. [Abstract] [Full Text] [PDF] |
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H. Jaeschke, S. Neumann, G. Kleinau, S. Mueller, M. Claus, G. Krause, and R. Paschke An Aromatic Environment in the Vicinity of Serine 281 Is a Structural Requirement for Thyrotropin Receptor Function Endocrinology, April 1, 2006; 147(4): 1753 - 1760. [Abstract] [Full Text] [PDF] |
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A. De Leener, L. Montanelli, J. Van Durme, H. Chae, G. Smits, G. Vassart, and S. Costagliola Presence and Absence of Follicle-Stimulating Hormone Receptor Mutations Provide Some Insights into Spontaneous Ovarian Hyperstimulation Syndrome Physiopathology J. Clin. Endocrinol. Metab., February 1, 2006; 91(2): 555 - 562. [Abstract] [Full Text] [PDF] |
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K. J. Land, P. Gudapati, M. H. Kaplan, and G. S. Seetharamaiah Differential Requirement of Signal Transducer and Activator of Transcription-4 (Stat4) and Stat6 in a Thyrotropin Receptor-289-Adenovirus-Induced Model of Graves' Hyperthyroidism Endocrinology, January 1, 2006; 147(1): 111 - 119. [Abstract] [Full Text] [PDF] |
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P. N. Pichurin, C.-R. Chen, G. D. Chazenbalk, H. Aliesky, N. Pham, B. Rapoport, and S. M. McLachlan Targeted Expression of the Human Thyrotropin Receptor A-Subunit to the Mouse Thyroid: Insight into Overcoming the Lack of Response to A-Subunit Adenovirus Immunization J. Immunol., January 1, 2006; 176(1): 668 - 676. [Abstract] [Full Text] [PDF] |
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M. Claus, H. Jaeschke, G. Kleinau, S. Neumann, G. Krause, and R. Paschke A Hydrophobic Cluster in the Center of the Third Extracellular Loop Is Important for Thyrotropin Receptor Signaling Endocrinology, December 1, 2005; 146(12): 5197 - 5203. [Abstract] [Full Text] [PDF] |
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A. L. D. Riis, T. K. Hansen, S. Thiel, C. H. Gravholt, S. Gjedde, L. C. Gormsen, J. O. L. Jorgensen, J. Weeke, and N. Moller Thyroid hormone increases mannan-binding lectin levels Eur. J. Endocrinol., November 1, 2005; 153(5): 643 - 649. [Abstract] [Full Text] [PDF] |
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S. M. McLachlan, Y. Nagayama, and B. Rapoport Insight into Graves' Hyperthyroidism from Animal Models Endocr. Rev., October 1, 2005; 26(6): 800 - 832. [Abstract] [Full Text] [PDF] |
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M. Ascoli Learning New Tricks from an Old Dog: The Processing of the Intracellular Precursor of the Luteinizing Hormone Receptor (LHR) into the Mature Cell-Surface LHR Is a Regulated Process Endocrinology, August 1, 2005; 146(8): 3221 - 3223. [Full Text] [PDF] |
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B. Karges, S. Gidenne, C. Aumas, F. Haddad, P. A. Kelly, E. Milgrom, and N. de Roux Zero-Length Cross-Linking Reveals that Tight Interactions between the Extracellular and Transmembrane Domains of the Luteinizing Hormone Receptor Persist during Receptor Activation Mol. Endocrinol., August 1, 2005; 19(8): 2086 - 2098. [Abstract] [Full Text] [PDF] |
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Y. Kubo, S. Sekiya, M. Ohigashi, C. Takenaka, K. Tamura, S. Nada, T. Nishi, A. Yamamoto, and A. Yamaguchi ABCA5 Resides in Lysosomes, and ABCA5 Knockout Mice Develop Lysosomal Disease-Like Symptoms Mol. Cell. Biol., May 15, 2005; 25(10): 4138 - 4149. [Abstract] [Full Text] [PDF] |
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P. Agretti, G. De Marco, M. De Servi, C. Marcocci, P. Vitti, A. Pinchera, and M. Tonacchera Evidence for protein and mRNA TSHr expression in fibroblasts from patients with thyroid-associated ophthalmopathy (TAO) after adipocytic differentiation Eur. J. Endocrinol., May 1, 2005; 152(5): 777 - 784. [Abstract] [Full Text] [PDF] |
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S. Neumann, M. Claus, and R. Paschke Interactions between the extracellular domain and the extracellular loops as well as the 6th transmembrane domain are necessary for TSH receptor activation Eur. J. Endocrinol., April 1, 2005; 152(4): 625 - 634. [Abstract] [Full Text] [PDF] |
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S. M. McLachlan, H. Braley-Mullen, C.-R. Chen, H. Aliesky, P. N. Pichurin, and B. Rapoport Dissociation between Iodide-Induced Thyroiditis and Antibody-Mediated Hyperthyroidism in NOD.H-2h4 Mice Endocrinology, January 1, 2005; 146(1): 294 - 300. [Abstract] [Full Text] [PDF] |
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G. Kleinau, H. Jaschke, S. Neumann, J. Lattig, R. Paschke, and G. Krause Identification of a Novel Epitope in the Thyroid-stimulating Hormone Receptor Ectodomain Acting as Intramolecular Signaling Interface J. Biol. Chem., December 3, 2004; 279(49): 51590 - 51600. [Abstract] [Full Text] [PDF] |
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S. Costagliola, M. Bonomi, N. G. Morgenthaler, J. Van Durme, V. Panneels, S. Refetoff, and G. Vassart Delineation of the Discontinuous-Conformational Epitope of a Monoclonal Antibody Displaying Full in Vitro and in Vivo Thyrotropin Activity Mol. Endocrinol., December 1, 2004; 18(12): 3020 - 3034. [Abstract] [Full Text] [PDF] |
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R. Latif, T. Ando, and T. F. Davies Monomerization as a Prerequisite for Intramolecular Cleavage and Shedding of the Thyrotropin Receptor Endocrinology, December 1, 2004; 145(12): 5580 - 5588. [Abstract] [Full Text] [PDF] |
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P. N. Pichurin, G. D. Chazenbalk, H. Aliesky, O. Pichurina, B. Rapoport, and S. M. McLachlan "Hijacking" the Thyrotropin Receptor: A Chimeric Receptor-Lysosome Associated Membrane Protein Enhances Deoxyribonucleic Acid Vaccination and Induces Graves' Hyperthyroidism Endocrinology, December 1, 2004; 145(12): 5504 - 5514. [Abstract] [Full Text] [PDF] |
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T. Ando, R. Latif, S. Daniel, K. Eguchi, and T. F. Davies Dissecting Linear and Conformational Epitopes on the Native Thyrotropin Receptor Endocrinology, November 1, 2004; 145(11): 5185 - 5193. [Abstract] [Full Text] [PDF] |
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Y. Nagayama, S. M. McLachlan, B. Rapoport, and K. Oishi Graves' Hyperthyroidism and the Hygiene Hypothesis in a Mouse Model Endocrinology, November 1, 2004; 145(11): 5075 - 5079. [Abstract] [Full Text] [PDF] |
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W. R. Moyle, Y. Xing, W. Lin, D. Cao, R. V. Myers, J. E. Kerrigan, and M. P. Bernard Model of Glycoprotein Hormone Receptor Ligand Binding and Signaling J. Biol. Chem., October 22, 2004; 279(43): 44442 - 44459. [Abstract] [Full Text] [PDF] |
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F. Latrofa, G. D. Chazenbalk, P. Pichurin, C.-R. Chen, S. M. McLachlan, and B. Rapoport Affinity-Enrichment of Thyrotropin Receptor Autoantibodies from Graves' Patients and Normal Individuals Provides Insight into Their Properties and Possible Origin from Natural Antibodies J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4734 - 4745. [Abstract] [Full Text] [PDF] |
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M. De Felice, M. P. Postiglione, and R. Di Lauro Minireview: Thyrotropin Receptor Signaling in Development and Differentiation of the Thyroid Gland: Insights from Mouse Models and Human Diseases Endocrinology, September 1, 2004; 145(9): 4062 - 4067. [Full Text] [PDF] |
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N. R. Farid and M. W. Szkudlinski Minireview: Structural and Functional Evolution of the Thyrotropin Receptor Endocrinology, September 1, 2004; 145(9): 4048 - 4057. [Abstract] [Full Text] [PDF] |
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K. J. Land, J. S. Moll, M. H. Kaplan, and G. S. Seetharamaiah Signal Transducer and Activator of Transcription (Stat)-6-Dependent, But Not Stat4-Dependent, Immunity Is Required for the Development of Autoimmunity in Graves' Hyperthyroidism Endocrinology, August 1, 2004; 145(8): 3724 - 3730. [Abstract] [Full Text] [PDF] |
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Y. Nagayama, K. Watanabe, M. Niwa, S. M. McLachlan, and B. Rapoport Schistosoma mansoni and {alpha}-Galactosylceramide: Prophylactic Effect of Th1 Immune Suppression in a Mouse Model of Graves' Hyperthyroidism J. Immunol., August 1, 2004; 173(3): 2167 - 2173. [Abstract] [Full Text] [PDF] |
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G. D. Chazenbalk, F. Latrofa, S. M. McLachlan, and B. Rapoport Thyroid Stimulation Does Not Require Antibodies with Identical Epitopes But Does Involve Recognition of a Critical Conformation at the N Terminus of the Thyrotropin Receptor A-Subunit J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1788 - 1793. [Abstract] [Full Text] [PDF] |
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T. Muehlberg, J. A. Gilbert, P. V. Rao, A. M. McGregor, and J. P. Banga Dynamics of Thyroid-Stimulating and -Blocking Antibodies to the Thyrotropin Receptor in a Murine Model of Graves' Disease Endocrinology, April 1, 2004; 145(4): 1539 - 1545. [Abstract] [Full Text] [PDF] |
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H. P. Ng, J. Paul Banga, and A. W. C. Kung Development of a Murine Model of Autoimmune Thyroiditis Induced with Homologous Mouse Thyroid Peroxidase Endocrinology, February 1, 2004; 145(2): 809 - 816. [Abstract] [Full Text] [PDF] |
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W. B. Minich, C. Lenzner, A. Bergmann, and N. G. Morgenthaler A Coated Tube Assay for the Detection of Blocking Thyrotropin Receptor Autoantibodies J. Clin. Endocrinol. Metab., January 1, 2004; 89(1): 352 - 356. [Abstract] [Full Text] [PDF] |
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G. D. Chazenbalk, C.-R. Chen, S. M. McLachlan, and B. Rapoport Does Thyrotropin Cleave Its Cognate Receptor? Endocrinology, January 1, 2004; 145(1): 4 - 10. [Abstract] [Full Text] [PDF] |
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J. Van Sande, M. J. Costa, C. Massart, S. Swillens, S. Costagliola, J. Orgiazzi, and J. E. Dumont Kinetics of Thyrotropin-Stimulating Hormone (TSH) and Thyroid-Stimulating Antibody Binding and Action on the TSH Receptor in Intact TSH Receptor-Expressing CHO Cells J. Clin. Endocrinol. Metab., November 1, 2003; 88(11): 5366 - 5374. [Abstract] [Full Text] [PDF] |
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Y. Tomer and T. F. Davies Searching for the Autoimmune Thyroid Disease Susceptibility Genes: From Gene Mapping to Gene Function Endocr. Rev., October 1, 2003; 24(5): 694 - 717. [Abstract] [Full Text] [PDF] |
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D. Fuhrer, M. D. Lewis, F. Alkhafaji, K. Starkey, R. Paschke, D. Wynford-Thomas, M. Eggo, and M. Ludgate Biological Activity of Activating Thyroid-Stimulating Hormone Receptor Mutants Depends on the Cellular Context Endocrinology, September 1, 2003; 144(9): 4018 - 4030. [Abstract] [Full Text] [PDF] |
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I. Ciullo, R. Latif, P. Graves, and T. F. Davies Functional Assessment of the Thyrotropin Receptor-{beta} Subunit Endocrinology, July 1, 2003; 144(7): 3176 - 3181. [Abstract] [Full Text] [PDF] |
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R. S. Bahn Pathophysiology of Graves' Ophthalmopathy: The Cycle of Disease J. Clin. Endocrinol. Metab., May 1, 2003; 88(5): 1939 - 1946. [Full Text] [PDF] |
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L. Schwarz-Lauer, P. N. Pichurin, C.-R. Chen, Y. Nagayama, C. Paras, J. C. Morris, B. Rapoport, and S. M. McLachlan The Cysteine-Rich Amino Terminus of the Thyrotropin Receptor Is the Immunodominant Linear Antibody Epitope in Mice Immunized Using Naked Deoxyribonucleic Acid or Adenovirus Vectors Endocrinology, May 1, 2003; 144(5): 1718 - 1725. [Abstract] [Full Text] [PDF] |
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C. H. Na, M. H. Lee, B. Y. Cho, and C.-B. Chae A Method for Identification of the Peptides That Bind to a Clone of Thyroid-Stimulating Antibodies in the Serum of Graves' Disease Patients J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1570 - 1576. [Abstract] [Full Text] [PDF] |
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Y. Nagayama, H. Mizuguchi, T. Hayakawa, M. Niwa, S. M. McLachlan, and B. Rapoport Prevention of Autoantibody-Mediated Graves'-Like Hyperthyroidism in Mice with IL-4, a Th2 Cytokine J. Immunol., April 1, 2003; 170(7): 3522 - 3527. [Abstract] [Full Text] [PDF] |
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J. Ginsberg Diagnosis and management of Graves' disease Can. Med. Assoc. J., March 4, 2003; 168(5): 575 - 585. [Abstract] [Full Text] [PDF] |
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T. Y. Kim, Y. J. Park, D. J. Park, H.-K. Chung, W. B. Kim, L. D. Kohn, and B. Y. Cho Epitope Heterogeneity of Thyroid-Stimulating Antibodies Predicts Long-Term Outcome in Graves' Patients Treated with Antithyroid Drugs J. Clin. Endocrinol. Metab., January 1, 2003; 88(1): 117 - 124. [Abstract] [Full Text] [PDF] |
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P. V. Rao, P. F. Watson, A. P. Weetman, G. Carayanniotis, and J. P. Banga Contrasting Activities of Thyrotropin Receptor Antibodies in Experimental Models of Graves' Disease Induced by Injection of Transfected Fibroblasts or Deoxyribonucleic Acid Vaccination Endocrinology, January 1, 2003; 144(1): 260 - 266. [Abstract] [Full Text] [PDF] |
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R. Latif, P. Graves, and T. F. Davies Ligand-dependent Inhibition of Oligomerization at the Human Thyrotropin Receptor J. Biol. Chem., November 15, 2002; 277(47): 45059 - 45067. [Abstract] [Full Text] [PDF] |
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M. Ascoli, F. Fanelli, and D. L. Segaloff The Lutropin/Choriogonadotropin Receptor, A 2002 Perspective Endocr. Rev., April 1, 2002; 23(2): 141 - 174. [Abstract] [Full Text] [PDF] |
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G. Smits, C. Govaerts, I. Nubourgh, L. Pardo, G. Vassart, and S. Costagliola Lysine 183 and Glutamic Acid 157 of the TSH Receptor: Two Interacting Residues with a Key Role in Determining Specificity toward TSH and Human CG Mol. Endocrinol., April 1, 2002; 16(4): 722 - 735. [Abstract] [Full Text] [PDF] |
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V. Vlaeminck-Guillem, S.-C. Ho, P. Rodien, G. Vassart, and S. Costagliola Activation of the cAMP Pathway by the TSH Receptor Involves Switching of the Ectodomain from a Tethered Inverse Agonist to an Agonist Mol. Endocrinol., April 1, 2002; 16(4): 736 - 746. [Abstract] [Full Text] [PDF] |
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M. W. Szkudlinski, V. Fremont, C. Ronin, and B. D. Weintraub Thyroid-Stimulating Hormone and Thyroid-Stimulating Hormone Receptor Structure-Function Relationships Physiol Rev, April 1, 2002; 82(2): 473 - 502. [Abstract] [Full Text] [PDF] |
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Y. Nagayama, M. Kita-Furuyama, T. Ando, K. Nakao, H. Mizuguchi, T. Hayakawa, K. Eguchi, and M. Niwa A Novel Murine Model of Graves' Hyperthyroidism with Intramuscular Injection of Adenovirus Expressing the Thyrotropin Receptor J. Immunol., March 15, 2002; 168(6): 2789 - 2794. [Abstract] [Full Text] [PDF] |
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M. P. Armengol, M. Juan, A. Lucas-Martin, M. T. Fernandez-Figueras, D. Jaraquemada, T. Gallart, and R. Pujol-Borrell Thyroid Autoimmune Disease : Demonstration of Thyroid Antigen-Specific B Cells and Recombination-Activating Gene Expression in Chemokine-Containing Active Intrathyroidal Germinal Centers Am. J. Pathol., September 1, 2001; 159(3): 861 - 873. [Abstract] [Full Text] [PDF] |
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P. Pichurin, X.-M. Yan, L. Farilla, J. Guo, G. D. Chazenbalk, B. Rapoport, and S. M. McLachlan Naked TSH Receptor DNA Vaccination: A TH1 T Cell Response in Which Interferon-{gamma} Production, Rather than Antibody, Dominates the Immune Response in Mice Endocrinology, August 1, 2001; 142(8): 3530 - 3536. [Abstract] [Full Text] [PDF] |
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G. D. Chazenbalk, S. M. McLachlan, P. Pichurin, X.-M. Yan, and B. Rapoport A Prion-Like Shift between Two Conformational Forms of a Recombinant Thyrotropin Receptor A-Subunit Module: Purification and Stabilization Using Chemical Chaperones of the Form Reactive with Graves' Autoantibodies J. Clin. Endocrinol. Metab., March 1, 2001; 86(3): 1287 - 1293. [Abstract] [Full Text] |
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D. Russo, C. Betterle, F. Arturi, E. Chiefari, M. E. Girelli, and S. Filetti A Novel Mutation in the Thyrotropin (TSH) Receptor Gene Causing Loss of TSH Binding But Constitutive Receptor Activation in a Family with Resistance to TSH J. Clin. Endocrinol. Metab., November 1, 2000; 85(11): 4238 - 4242. [Abstract] [Full Text] |
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A. P. Weetman Graves' Disease N. Engl. J. Med., October 26, 2000; 343(17): 1236 - 1248. [Full Text] [PDF] |
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Y. Nagayama, E. Nishihara, H. Namba, S. Yamashita, and M. Niwa Identification of the Sites of Asparagine-Linked Glycosylation on the Human Thyrotropin Receptor and Studies on Their Role in Receptor Function and Expression J. Pharmacol. Exp. Ther., October 1, 2000; 295(1): 404 - 409. [Abstract] [Full Text] |
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K. Tanaka, G. D. Chazenbalk, S. M. McLachlan, and B. Rapoport Evidence that Cleavage of the Thyrotropin Receptor Involves a "Molecular Ruler" Mechanism: Deletion of Amino Acid Residues 305-320 Causes a Spatial Shift in Cleavage Site 1 Independent of Amino Acid Motif Endocrinology, October 1, 2000; 141(10): 3573 - 3577. [Abstract] [Full Text] [PDF] |
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Y.-X. Tao, A. N. Abell, X. Liu, K. Nakamura, and D. L. Segaloff Constitutive Activation of G Protein-Coupled Receptors as a Result of Selective Substitution of a Conserved Leucine Residue in Transmembrane Helix III Mol. Endocrinol., August 1, 2000; 14(8): 1272 - 1282. [Abstract] [Full Text] |
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T. Akamizu, L. D. Kohn, H. Hiratani, M. Saijo, K. Tahara, and K. Nakao Hashimoto's Thyroiditis with Heterogeneous Antithyrotropin Receptor Antibodies: Unique Epitopes May Contribute to the Regulation of Thyroid Function by the Antibodies J. Clin. Endocrinol. Metab., June 1, 2000; 85(6): 2116 - 2121. [Abstract] [Full Text] |
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J. Chung, E. S. Park, D. Kim, J. M. Suh, H. K. Chung, J. Kim, H. Kim, S. J. Park, O-Y. Kwon, H. K. Ro, et al. Thyrotropin Modulates Interferon-{gamma}-Mediated Intercellular Adhesion Molecule-1 Gene Expression by Inhibiting Janus Kinase-1 and Signal Transducer and Activator of Transcription-1 Activation in Thyroid Cells Endocrinology, June 1, 2000; 141(6): 2090 - 2097. [Abstract] [Full Text] [PDF] |
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E. S. Park, H. Kim, J. M. Suh, S. J. Park, S. H. You, H. K. Chung, K. W. Lee, O-Y. Kwon, B. Y. Cho, Y. K. Kim, et al. Involvement of JAK/STAT (Janus Kinase/Signal Transducer and Activator of Transcription) in the Thyrotropin Signaling Pathway Mol. Endocrinol., May 1, 2000; 14(5): 662 - 670. [Abstract] [Full Text] |
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J. Bolton, J. Sanders, Y. Oda, C. Chapman, R. Konno, J. Furmaniak, and B. Rees Smith Measurement of Thyroid-stimulating Hormone Receptor Autoantibodies by ELISA Clin. Chem., December 1, 1999; 45(12): 2285 - 2287. [Full Text] [PDF] |
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K. Tanaka, G. D. Chazenbalk, S. M. McLachlan, and B. Rapoport Subunit Structure of Thyrotropin Receptors Expressed on the Cell Surface J. Biol. Chem., November 26, 1999; 274(48): 33979 - 33984. [Abstract] [Full Text] [PDF] |
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J. Sanders, Y. Oda, S. Roberts, A. Kiddie, T. Richards, J. Bolton, V. McGrath, S. Walters, D. Jaskolski, J. Furmaniak, et al. The Interaction of TSH Receptor Autoantibodies with 125I-Labelled TSH Receptor J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3797 - 3802. [Abstract] [Full Text] [PDF] |
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H. Devos, C. Rodd, N. Gagné, R. Laframboise, and G. Van Vliet A Search for the Possible Molecular Mechanisms of Thyroid Dysgenesis: Sex Ratios and Associated Malformations J. Clin. Endocrinol. Metab., July 1, 1999; 84(7): 2502 - 2506. [Abstract] [Full Text] |
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J. C. Jaume, J. Guo, Y. Wang, B. Rapoport, and S. M. McLachlan Cellular Thyroid Peroxidase (TPO), Unlike Purified TPO and Adjuvant, Induces Antibodies in Mice That Resemble Autoantibodies in Human Autoimmune Thyroid Disease J. Clin. Endocrinol. Metab., May 1, 1999; 84(5): 1651 - 1657. [Abstract] [Full Text] |
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J. C. Jaume, J. Guo, D. L. Pauls, M. Zakarija, J. M. McKenzie, J. A. Egeland, C. L. Burek, N. R. Rose, W. H. Hoffman, B. Rapoport, et al. Evidence for Genetic Transmission of Thyroid Peroxidase Autoantibody Epitopic "Fingerprints" J. Clin. Endocrinol. Metab., April 1, 1999; 84(4): 1424 - 1431. [Abstract] [Full Text] |
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G. D. Chazenbalk, Y. Wang, J. Guo, J. S. Hutchison, D. Segal, J. C. Jaume, S. M. McLachlan, and B. Rapoport A Mouse Monoclonal Antibody to a Thyrotropin Receptor Ectodomain Variant Provides Insight into the Exquisite Antigenic Conformational Requirement, Epitopes and in Vivo Concentration of Human Autoantibodies J. Clin. Endocrinol. Metab., February 1, 1999; 84(2): 702 - 710. [Abstract] [Full Text] |
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K. Tanaka, G. D. Chazenbalk, S. M. McLachlan, and B. Rapoport Thyrotropin Receptor Cleavage at Site 1 Involves Two Discontinuous Segments at Each End of the Unique 50-Amino Acid Insertion J. Biol. Chem., January 22, 1999; 274(4): 2093 - 2096. [Abstract] [Full Text] [PDF] |
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H. Kishi and M. Ascoli Multiple Distant Amino Acid Residues Present in the Serpentine Region of the Follitropin Receptor Modulate the Rate of Agonist-induced Internalization J. Biol. Chem., September 29, 2000; 275(40): 31030 - 31037. [Abstract] [Full Text] [PDF] |
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K. Nakabayashi, M. Kudo, B. Kobilka, and A. J. W. Hsueh Activation of the Luteinizing Hormone Receptor Following Substitution of Ser-277 with Selective Hydrophobic Residues in the Ectodomain Hinge Region J. Biol. Chem., September 22, 2000; 275(39): 30264 - 30271. [Abstract] [Full Text] [PDF] |
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C.-R. Chen, K. Tanaka, G. D. Chazenbalk, S. M. McLachlan, and B. Rapoport A Full Biological Response to Autoantibodies in Graves' Disease Requires a Disulfide-bonded Loop in the Thyrotropin Receptor N Terminus Homologous to a Laminin Epidermal Growth Factor-like Domain J. Biol. Chem., April 27, 2001; 276(18): 14767 - 14772. [Abstract] [Full Text] [PDF] |
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S. Li, X. Liu, L. Min, and M. Ascoli Mutations of the Second Extracellular Loop of the Human Lutropin Receptor Emphasize the Importance of Receptor Activation and De-emphasize the Importance of Receptor Phosphorylation in Agonist-induced Internalization J. Biol. Chem., March 9, 2001; 276(11): 7968 - 7973. [Abstract] [Full Text] [PDF] |
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R. Latif, P. Graves, and T. F. Davies Oligomerization of the Human Thyrotropin Receptor. FLUORESCENT PROTEIN-TAGGED hTSHR REVEALS POST-TRANSLATIONAL COMPLEXES J. Biol. Chem., November 21, 2001; 276(48): 45217 - 45224. [Abstract] [Full Text] [PDF] |
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