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Endocrine Reviews 19 (5): 608-624
Copyright © 1998 by The Endocrine Society

Insulin Degradation: Progress and Potential1

William C. Duckworth, Robert G. Bennett and Frederick G. Hamel

Veterans Affairs Medical Center (W.C.D., R.G.B., F.G.H.), Omaha, Nebraska 68105; and Departments of Medicine (W.C.D., F.G.H.), Biochemistry and Molecular Biology (W.C.D., R.G.B.), and Pharmacology (F.G.H.), University of Nebraska Medical Center, Omaha, Nebraska 68193-3020

I. Introduction
II. Insulin Clearance
A. Liver
B. Kidney
C. Other tissues
D. Extracellular insulin degradation
III. Cellular Insulin Uptake
IV. Cellular Insulin Degradation
A. Degradation products
B. Assay for insulin degradation
C. Insulin-degrading enzymes
V. Biological Role of Insulin Degradation
VI. Insulin-IDE-Proteasome Interactions and Control of Protein Degradation
VII. Summary and Conclusions




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