William C. Duckworth,
Robert G. Bennett and
Frederick G. Hamel
Veterans Affairs Medical Center (W.C.D., R.G.B., F.G.H.),
Omaha, Nebraska 68105; and Departments of Medicine (W.C.D., F.G.H.),
Biochemistry and Molecular Biology (W.C.D., R.G.B.), and Pharmacology
(F.G.H.), University of Nebraska Medical Center, Omaha, Nebraska
68193-3020
I. Introduction
II. Insulin Clearance
A. Liver
B. Kidney
C. Other tissues
D. Extracellular insulin degradation
III.Cellular Insulin Uptake
IV. Cellular Insulin Degradation
A.Degradation products
B. Assay for insulin degradation
C.Insulin-degrading enzymes
V. Biological Role of Insulin Degradation
VI. Insulin-IDE-Proteasome Interactions and Control of ProteinDegradation
VII. Summary and Conclusions
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