help button home button Endocrine Society Endocrine Reviews
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sasano, H.
Right arrow Articles by Harada, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sasano, H.
Right arrow Articles by Harada, N.
Endocrine Reviews 19 (5): 593-607
Copyright © 1998 by The Endocrine Society

Intratumoral Aromatase in Human Breast, Endometrial, and Ovarian Malignancies1

Hironobu Sasano and Nobuhiro Harada

Department of Pathology (H.S.), Tohoku University School of Medicine, Sendai 980-8575, Japan; and Division of Molecular Genetics (N.H.), Institute for Comprehensive Medical Science, Fujita Health University, Toyoake 470-1192, Japan

I. Introduction
II. Aromatase Cytochrome P450 and in Situ Estrogen Production
III. Aromatase in Breast Cancer
A. Introduction
B. Localization
C. Genetic regulation
D. Clinical and pathological correlation
E. Male breast cancer
IV. Aromatase in Endometrial Cancer
A. Introduction
B. Localization
C. Genetic regulation
D. Clinical and pathological correlation
V. Aromatase in Ovarian Cancer
A. Introduction
B. Localization
C. Genetic regulation
D. Clinical and pathological correlation
VI. Summary




This article has been cited by other articles:


Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
J. Beesley, S. J. Jordan, A. B. Spurdle, H. Song, S. J. Ramus, S. K. Kjaer, E. Hogdall, R. A. DiCioccio, V. McGuire, A. S. Whittemore, et al.
Association Between Single-Nucleotide Polymorphisms in Hormone Metabolism and DNA Repair Genes and Epithelial Ovarian Cancer: Results from Two Australian Studies and an Additional Validation Set
Cancer Epidemiol. Biomarkers Prev., December 1, 2007; 16(12): 2557 - 2565.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Lu, D. Chen, Z. Lin, S. Reierstad, A. M. Trauernicht, T. G. Boyer, and S. E. Bulun
BRCA1 Negatively Regulates the Cancer-Associated Aromatase Promoters I.3 and II in Breast Adipose Fibroblasts and Malignant Epithelial Cells
J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4514 - 4519.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
T. Suzuki, Y. Miki, Y. Nakamura, T. Moriya, K. Ito, N. Ohuchi, and H. Sasano
Sex steroid-producing enzymes in human breast cancer
Endocr. Relat. Cancer, December 1, 2005; 12(4): 701 - 720.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
M. Watanabe, S. Ohno, and S. Nakajin
Forskolin and dexamethasone synergistically induce aromatase (CYP19) expression in the human osteoblastic cell line SV-HFO
Eur. J. Endocrinol., April 1, 2005; 152(4): 619 - 624.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
W. Fan, T. Yanase, H. Morinaga, Y.-M. Mu, M. Nomura, T. Okabe, K. Goto, N. Harada, and H. Nawata
Activation of Peroxisome Proliferator-Activated Receptor-{gamma} and Retinoid X Receptor Inhibits Aromatase Transcription via Nuclear Factor-{kappa}B
Endocrinology, January 1, 2005; 146(1): 85 - 92.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. Miyoshi, S. J. Kim, K. Akazawa, S. Kamigaki, S. Ueda, T. Yanagisawa, T. Inoue, T. Taguchi, Y. Tamaki, and S. Noguchi
Down-Regulation of Intratumoral Aromatase Messenger RNA Levels by Docetaxel in Human Breast Cancers
Clin. Cancer Res., December 15, 2004; 10(24): 8163 - 8169.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
S. Matsuzaki, M. Canis, C. Vaurs-Barriere, J.L. Pouly, O. Boespflug-Tanguy, F. Penault-Llorca, P. Dechelotte, B. Dastugue, K. Okamura, and G. Mage
DNA microarray analysis of gene expression profiles in deep endometriosis using laser capture microdissection
Mol. Hum. Reprod., October 1, 2004; 10(10): 719 - 728.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
E Sivridis and A Giatromanolaki
Proliferative activity in postmenopausal endometrium: the lurking potential for giving rise to an endometrial adenocarcinoma
J. Clin. Pathol., August 1, 2004; 57(8): 840 - 844.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Suzuki, Y. Miki, T. Moriya, N. Shimada, T. Ishida, H. Hirakawa, N. Ohuchi, and H. Sasano
Estrogen-Related Receptor {alpha} in Human Breast Carcinoma as a Potent Prognostic Factor
Cancer Res., July 1, 2004; 64(13): 4670 - 4676.
[Abstract] [Full Text] [PDF]

Home page
 INT J SURG PATHOLHome page
E. Sivridis and A. Giatromanolaki
Endometrial Adenocarcinoma: Beliefs and Scepticism
International Journal of Surgical Pathology, April 1, 2004; 12(2): 99 - 105.
[Abstract] [PDF]

Home page
 Am. J. Pathol.Home page
Y. Nakamura, Y. Miki, T. Suzuki, T. Nakata, A. D. Darnel, T. Moriya, C. Tazawa, H. Saito, T. Ishibashi, S. Takahashi, et al.
Steroid Sulfatase and Estrogen Sulfotransferase in the Atherosclerotic Human Aorta
Am. J. Pathol., October 1, 2003; 163(4): 1329 - 1339.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
H. Masuyama, Y. Hiramatsu, J.-i. Kodama, and T. Kudo
Expression and Potential Roles of Pregnane X Receptor in Endometrial Cancer
J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4446 - 4454.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. M. Martin, C. J. Lin, M. Y. Nishi, A. E. C. Billerbeck, A. C. Latronico, D. W. Russell, and B. B. Mendonca
Familial Hyperestrogenism in Both Sexes: Clinical, Hormonal, and Molecular Studies of Two Siblings
J. Clin. Endocrinol. Metab., July 1, 2003; 88(7): 3027 - 3034.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
H. Utsunomiya, T. Suzuki, C. Kaneko, J. Takeyama, J. Nakamura, K. Kimura, M. Yoshihama, N. Harada, K. Ito, R. Konno, et al.
The Analyses of 17{beta}-Hydroxysteroid Dehydrogenase Isozymes in Human Endometrial Hyperplasia and Carcinoma
J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3436 - 3443.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
J. F. Dorgan, D. J. Baer, P. S. Albert, J. T. Judd, E. D. Brown, D. K. Corle, W. S. Campbell, T. J. Hartman, A. A. Tejpar, B. A. Clevidence, et al.
Serum Hormones and the Alcohol-Breast Cancer Association in Postmenopausal Women
J Natl Cancer Inst, May 2, 2001; 93(9): 710 - 715.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. P. V. Shekhar, J. Werdell, S. J. Santner, R. J. Pauley, and L. Tait
Breast Stroma Plays a Dominant Regulatory Role in Breast Epithelial Growth and Differentiation: Implications for Tumor Development and Progression
Cancer Res., February 1, 2001; 61(4): 1320 - 1326.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. J. Pauley, S. J. Santner, L. R. Tait, R. K. Bright, and R. J. Santen
Regulated CYP19 Aromatase Transcription in Breast Stromal Fibroblasts
J. Clin. Endocrinol. Metab., February 1, 2000; 85(2): 837 - 846.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
M. Maggiolini, O. Donze, E. Jeannin, S. Ando, and D. Picard
Adrenal Androgens Stimulate the Proliferation of Breast Cancer Cells as Direct Activators of Estrogen Receptor {{alpha}}
Cancer Res., October 1, 1999; 59(19): 4864 - 4869.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1998 by The Endocrine Society