Sex Steroid Treatment of Constitutionally Tall Stature1
Stenvert L. S. Drop,
Wouter J. de Waal and
Sabine M. P. F. de Muinck Keizer-Schrama
Department of Pediatrics, Division of Endocrinology, Sophia
Children’s Hospital, Erasmus University, 3000 CB Rotterdam, The
Netherlands
I. Introduction
II. Normal vs. Extremes of Growth
A. DefiningCTS
B. Endocrinology of CTS
III. Endocrinology of Bone Growthand Maturation
IV. Sex Steroid Action on Bone Growth and Maturation
V. Height Prediction
A. Skeletal maturity or BA
B. Computedassisted skeletal age-scoring systems
C. Accuracy of heightprediction
D. New prediction equations in constitutionallytall children
VI. Treatment of CTS: General Concepts
VII.Treatment of Constitutionally Tall Boys
A. T treatment modalities
B. Height reduction
C. Effects on gonadal function
D.Other clinical effects
VIII. Estrogen Treatment in Tall Girls
A. Estrogen treatment modalities
B. Height reduction
C.Effects on gonadal function
D. Other adverse effects
IX.Alternative Treatment Modalities and Future Research
X. Conclusionsand Recommendations
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