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*Diabetes
Endocrine Reviews 19 (4): 477-490
Copyright © 1998 by The Endocrine Society

Insulin Resistance versus Insulin Deficiency in Non-Insulin-Dependent Diabetes Mellitus: Problems and Prospects

Ele Ferrannini

C.N.R. Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa, 56126 Pisa, Italy

I. Introduction
II. Preliminary Issues
A. Prevalence of insulin resistance in NIDDM
B. Methodology
C. Source data
III. Insulin Resistance vs. Insulin Deficiency
A. High-risk conditions and predictors
B. The problem by mechanism
C. The genetic approach
IV. Summary
V. Insulin Resistance: The Cluster Concept
VI. Prospects




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