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Endocrine Reviews 19 (4): 429-461
Copyright © 1998 by The Endocrine Society

Protein Kinases, Protein Phosphorylation, and the Regulation of Insulin Secretion from Pancreatic ß-Cells.

Peter M. Jones and Shanta J. Persaud

Cellular and Molecular Endocrinology Group, Biomedical Sciences Division, King’s College London, Campden Hill Road, Kensington, London, W8 7AH, United Kingdom

I. Introduction
II. Protein Kinases in ß-Cells: Expression and Characteristics
A. Ca2+/calmodulin-dependent protein kinases
B. Cyclic nucleotide-dependent protein kinases
C. Ca2+/phospholipid-dependent protein kinases
D. Mitogen-activated protein kinases
E. Protein tyrosine kinases
III. Phosphorylation of Endogenous Proteins in ß-Cells
A. Methods for studying protein phosphorylation in ß-cells
B. Endogenous kinase substrates in ß-cells
IV. Protein Kinases and the Regulation of Insulin Secretion
A. Ca2+/calmodulin-dependent protein kinases
B. Cyclic nucleotide-dependent protein kinases
C. Ca2+/phospholipid-dependent protein kinases
D. Mitogen-activated protein kinases
E. Protein tyrosine kinases
V. Protein Phosphatases and Protein Dephosphorylation in ß-Cells
A. Serine/threonine protein phosphatases
B. Protein phosphatases in ß-cells
VI. Protein Kinase-Independent Secretory Pathways
VII. Summary and Future Perspectives




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