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Endocrine Reviews 19 (3): 331-348
Copyright © 1998 by The Endocrine Society

Biological Esterification of Steroids1

Richard B. Hochberg

Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06510

I. Introduction
A. Obfuscating chemistry and the presumptive steroid acetates
B. Sterol esters: substrates for the cholesterol side-chain cleavage enzyme
II. Lipoidal Derivatives of {Delta}5-3ß-Hydroxysteroids in the Adrenal and Ovary
A. Endogenous steroid esters
B. Biosynthetic esterification of {Delta}5-3ß-hydroxy-steroids
III. Lipoidal Derivatives of Steroids in Peripheral Tissues
A. Esterification of steroid hormones
B. Esterification of {Delta}5-3ß-hydroxysteroids
C. Endogenous esters of sex steroids
D. Androsterone esters in breast cyst fluid
IV. Lipoidal Derivatives Synthesized by Lecithin:Cholesterol Acyltransferase
A. Blood
B. Ovarian follicular fluid
V. Steroid Esterases
VI. Lipoidal Derivatives of Steroid Hormones in Insects
VII. Biological Effects of Steroid Esterification
A. Potent sex steroids
B. Unique actions of the steroid esters in blood
VIII. Conclusion




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