Brain Corticosteroid Receptor Balance in Health and Disease1
E. Ronald de Kloet,
Erno Vreugdenhil,
Melly S. Oitzl and
Marian Joëls
Division of Medical Pharmacology (E.R.D.K., E.V., M.S.O.),
Leiden/Amsterdam Center for Drug Research, University of Leiden, 2300
RA Leiden, The Netherlands; and Institute for Neurobiology (M.J.),
University of Amsterdam, 1098 SM Amsterdam, The Netherlands
I. Introduction
II. Corticosteroid Receptor Properties
A.Corticosteroid receptor diversity in brain and pituitary
B.Access of corticosteroids to brain receptors
C. Expressionof MR, GR, and receptor variants
D. Regulation of transcriptionalactivity
E. Conclusion
III. Molecular and Cellular Effectsof Corticosteroids in Hippocampus
A. Intrinsic cell properties
B. Amino acid transmission
C. Aminergic transmission
D.Chronic absence of corticosterone
E. Chronic exposure to highcorticosteroid levels
F. Conclusion
IV. Role of CorticosteroidReceptors in the Central Stress Response
A. Corticosteroidreceptors and HPA control
B. Role of hippocampus in HPA regulation
C. Behavioral effects involving hippocampal MR and GR
D.Glucocorticoid feedback resistance and supersensitivity
E.GR knockouts
F. Conclusion
V. Implications for Age- andStress-Related Brain Disorders
A. Role of genotype
B. Impactof early life experience
C. Corticosteroids and affectivedisorders
D. Aging, neurodegeneration, and age-related diseases
E. Conclusion
VI. Summary
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I. C. G. Weaver, F. A. Champagne, S. E. Brown, S. Dymov, S. Sharma, M. J. Meaney, and M. Szyf Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl Supplementation: Altering Epigenetic Marking Later in Life
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H. Karst and M. Joels Corticosterone Slowly Enhances Miniature Excitatory Postsynaptic Current Amplitude in Mice CA1 Hippocampal Cells
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E. Park, O. Chan, Q. Li, M. Kiraly, S. G. Matthews, M. Vranic, and M. C. Riddell Changes in basal hypothalamo-pituitary-adrenal activity during exercise training are centrally mediated
Am J Physiol Regulatory Integrative Comp Physiol,
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J. Zschocke, N. Bayatti, A. M. Clement, H. Witan, M. Figiel, J. Engele, and C. Behl Differential Promotion of Glutamate Transporter Expression and Function by Glucocorticoids in Astrocytes from Various Brain Regions
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R. Giordano, M. Bo, M. Pellegrino, M. Vezzari, M. Baldi, A. Picu, M. Balbo, L. Bonelli, G. Migliaretti, E. Ghigo, et al. Hypothalamus-Pituitary-Adrenal Hyperactivity in Human Aging Is Partially Refractory to Stimulation by Mineralocorticoid Receptor Blockade
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G. M. Kalabis, A. Kostaki, M. H. Andrews, S. Petropoulos, W. Gibb, and S. G. Matthews Multidrug Resistance Phosphoglycoprotein (ABCB1) in the Mouse Placenta: Fetal Protection
Biol Reprod,
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L. Pascual-Le Tallec and M. Lombes The Mineralocorticoid Receptor: A Journey Exploring Its Diversity and Specificity of Action
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K. A. Fenoglio, K. L. Brunson, S. Avishai-Eliner, B. A. Stone, B. J. Kapadia, and T. Z. Baram Enduring, Handling-Evoked Enhancement of Hippocampal Memory Function and Glucocorticoid Receptor Expression Involves Activation of the Corticotropin-Releasing Factor Type 1 Receptor
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J. J. Cerqueira, J. M. Pego, R. Taipa, J. M. Bessa, O. F. X. Almeida, and N. Sousa Morphological Correlates of Corticosteroid-Induced Changes in Prefrontal Cortex-Dependent Behaviors
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G. A. Lodygensky, K. Rademaker, S. Zimine, M. Gex-Fabry, A. F. Lieftink, F. Lazeyras, F. Groenendaal, L. S. de Vries, and P. S. Huppi Structural and Functional Brain Development After Hydrocortisone Treatment for Neonatal Chronic Lung Disease
Pediatrics,
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S. Chung, G. H. Son, S. H. Park, E. Park, K. H. Lee, D. Geum, and K. Kim Differential Adaptive Responses to Chronic Stress of Maternally Stressed Male Mice Offspring
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J. J. Volpe Encephalopathy of Prematurity Includes Neuronal Abnormalities
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S Hesketh, D S Jessop, S Hogg, and M S Harbuz Differential actions of acute and chronic citalopram on the rodent hypothalamic-pituitary-adrenal axis response to acute restraint stress
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X. Wang and D. B. DeFranco Alternative Effects of the Ubiquitin-Proteasome Pathway on Glucocorticoid Receptor Down-Regulation and Transactivation Are Mediated by CHIP, an E3 Ligase
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T. W. W. Pace and R. L. Spencer Disruption of mineralocorticoid receptor function increases corticosterone responding to a mild, but not moderate, psychological stressor
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L. Pascual-Le Tallec, F. Simone, S. Viengchareun, G. Meduri, M. J. Thirman, and M. Lombes The Elongation Factor ELL (Eleven-Nineteen Lysine-Rich Leukemia) Is a Selective Coregulator for Steroid Receptor Functions
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D. P. Merke, J. N. Giedd, M. F. Keil, S. L. Mehlinger, E. A. Wiggs, S. Holzer, E. Rawson, A. C. Vaituzis, C. A. Stratakis, and G. P. Chrousos Children Experience Cognitive Decline Despite Reversal of Brain Atrophy One Year After Resolution of Cushing Syndrome
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R. G. Smith, L. Betancourt, and Y. Sun Molecular Endocrinology and Physiology of the Aging Central Nervous System
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S. Kuhlmann, M. Piel, and O. T. Wolf Impaired Memory Retrieval after Psychosocial Stress in Healthy Young Men
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O. C. Meijer, B. Topic, P. J. Steenbergen, G. Jocham, J. P. Huston, and M. S. Oitzl Correlations between Hypothalamus-Pituitary-Adrenal Axis Parameters Depend on Age and Learning Capacity
Endocrinology,
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O. C. Meijer, E. Kalkhoven, S. van der Laan, P. J. Steenbergen, S. H. Houtman, T. F. Dijkmans, D. Pearce, and E. R. de Kloet Steroid Receptor Coactivator-1 Splice Variants Differentially Affect Corticosteroid Receptor Signaling
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