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The Diagnosis of Growth Hormone Deficiency in Children and Adults

Christie Hospital National Health Service Trust, Withington, Manchester M20 4BX, U.K.

I. Introduction

II. GHD in Children

A. Clinical aspects

B. Radiology

C. GH provocative tests

D. Physiological assessment of GH secretion

E. IGFs

F. IGFBPs

G. Newer strategies for assessment of GH status

H. Practical approach to the diagnosis of GHD

III. GHD in Adults

A. Clinical aspects

B. GH provocative tests

C. Physiological assessment of GH secretion

D. IGF-I and IGFBP-3

E. Obesity

F. Elderly

G. Childhood onset

H. Newer strategies for assessment of GH status

I. Practical approach to the diagnosis of GHD

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