Claes Ohlsson,
Bengt-Åke Bengtsson,
Olle G. P. Isaksson,
Troels T. Andreassen and
Maria C. Slootweg
Research Centre for Endocrinology and Metabolism (C.O., B-Å.B.,
O.I., M.S.), Sahlgrenska University Hospital, S-41345 Göteborg,
Sweden; Diabetes Branch (C.O.), The National Institute of Diabetes and
Digestive and Kidney Diseases, National Institutes of Health, Bethesda,
Maryland; Department of Connective Tissue Biology (T.T.A.), Institute
of Anatomy, University of Aarhus, Aarhus, Denmark; and Eli Lilly,
Netherlands (M.S.), Nieuwegein, Netherlands
I. Introduction
II. Effects of GH on Longitudinal Bone Growth
A. GH and regulation of postnatal longitudinal bone growth
B. Results supporting an important physiological role of IGF-Ifor bone
growth
C. Evaluation of the somatomedin theory vs.the dual effector
theory
III. Effect of GH in Vitro
A. Effectsof GH in bone tissue cultures
B. Effects of GH on osteoblasts
C. Effects of GH on osteoclasts
IV. Effects of GH on BoneMetabolism in Animals
A. Effects of GH deficiency and GH replacementon bone parameters
B. Effects of GH treatment on bone parametersof animals withnormal GH
secretion
C. Effects of GH on fracturehealing
V. Effects of GH on Bone Metabolism in Humans
A.Bone metabolism in patients with acromegaly and GH deficiency
B. Effects of the GH/IGF-I axis on bone metabolism and bonemass in
patients with normal GH secretion
VI. Summary andConclusions
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