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Endocrine Reviews 19 (1): 18-54
Copyright © 1998 by The Endocrine Society

Cancer and Bone1

Theresa A. Guise and Gregory R. Mundy

Division of Endocrinology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284-7877

I. Introduction
II. Normal Calcium and Bone Homeostasis
A. Bone remodeling
B. Calcium homeostasis
C. Defenses against hyper- and hypocalcemia
III. Humoral Mechanisms by Which Solid Tumors Affect the Skeleton
A. Hypercalcemia
B. Oncogenic osteomalacia
C. Tumor lysis syndrome
IV. Local Mechanisms by Which Tumors Affect the Skeleton
A. Clinical manifestations
B. Pathophysiology of the metastatic process to bone
C. Local tumor syndromes in bone
D. Therapy of tumor in bone




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