help button home button Endocrine Society Endocrine Reviews
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Guise, T. A.
Right arrow Articles by Mundy, G. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Guise, T. A.
Right arrow Articles by Mundy, G. R.
Endocrine Reviews 19 (1): 18-54
Copyright © 1998 by The Endocrine Society

Cancer and Bone1

Theresa A. Guise and Gregory R. Mundy

Division of Endocrinology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284-7877

I. Introduction
II. Normal Calcium and Bone Homeostasis
A. Bone remodeling
B. Calcium homeostasis
C. Defenses against hyper- and hypocalcemia
III. Humoral Mechanisms by Which Solid Tumors Affect the Skeleton
A. Hypercalcemia
B. Oncogenic osteomalacia
C. Tumor lysis syndrome
IV. Local Mechanisms by Which Tumors Affect the Skeleton
A. Clinical manifestations
B. Pathophysiology of the metastatic process to bone
C. Local tumor syndromes in bone
D. Therapy of tumor in bone




This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
J. Lorenzo, M. Horowitz, and Y. Choi
Osteoimmunology: Interactions of the Bone and Immune System
Endocr. Rev., June 1, 2008; 29(4): 403 - 440.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
G. R. Mundy and J. R. Edwards
PTH-Related Peptide (PTHrP) in Hypercalcemia
J. Am. Soc. Nephrol., April 1, 2008; 19(4): 672 - 675.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
R. R. Langley and I. J. Fidler
Tumor Cell-Organ Microenvironment Interactions in the Pathogenesis of Cancer Metastasis
Endocr. Rev., May 1, 2007; 28(3): 297 - 321.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
C. Van Sant, G. Wang, M. G. Anderson, O. J. Trask, R. Lesniewski, and D. Semizarov
Endothelin signaling in osteoblasts: global genome view and implication of the calcineurin/NFAT pathway
Mol. Cancer Ther., January 1, 2007; 6(1): 253 - 261.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. G. Marguiles, V. S. Klimberg, S. Bhattacharrya, D. Gaddy, and L. J. Suva
Genomics and Proteomics of Bone Cancer.
Clin. Cancer Res., October 15, 2006; 12(20): 6217s - 6221s.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
O. S. Bruland, S. Nilsson, D. R. Fisher, and R. H. Larsen
High-Linear Energy Transfer Irradiation Targeted to Skeletal Metastases by the {alpha}-Emitter 223Ra: Adjuvant or Alternative to Conventional Modalities?
Clin. Cancer Res., October 15, 2006; 12(20): 6250s - 6257s.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
D. J. Leeming, G. Delling, M. Koizumi, K. Henriksen, M. A. Karsdal, B. Li, P. Qvist, L. B. Tanko, and I. Byrjalsen
Alpha CTX as a Biomarker of Skeletal Invasion of Breast Cancer: Immunolocalization and the Load Dependency of Urinary Excretion.
Cancer Epidemiol. Biomarkers Prev., July 1, 2006; 15(7): 1392 - 1395.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
S. Hanavadi, T. A. Martin, G. Watkins, R. E. Mansel, and W. G. Jiang
Expression of Interleukin 11 and Its Receptor and Their Prognostic Value in Human Breast Cancer
Ann. Surg. Oncol., June 1, 2006; 13(6): 802 - 808.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
N. Normanno and W. J Gullick
Epidermal growth factor receptor tyrosine kinase inhibitors and bone metastases: different mechanisms of action for a novel therapeutic application?
Endocr. Relat. Cancer, March 1, 2006; 13(1): 3 - 6.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
A. Angelucci, G. L. Gravina, N. Rucci, D. Millimaggi, C. Festuccia, P. Muzi, A. Teti, C. Vicentini, and M. Bologna
Suppression of EGF-R signaling reduces the incidence of prostate cancer metastasis in nude mice.
Endocr. Relat. Cancer, March 1, 2006; 13(1): 197 - 210.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
H. Muguruma, S. Yano, S. Kakiuchi, H. Uehara, M. Kawatani, H. Osada, and S. Sone
Reveromycin A Inhibits Osteolytic Bone Metastasis of Small-Cell Lung Cancer Cells, SBC-5, through an Antiosteoclastic Activity
Clin. Cancer Res., December 15, 2005; 11(24): 8822 - 8828.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Miwa, A. Mizokami, E. T. Keller, R. Taichman, J. Zhang, and M. Namiki
The Bisphosphonate YM529 Inhibits Osteolytic and Osteoblastic Changes and CXCR-4-Induced Invasion in Prostate Cancer
Cancer Res., October 1, 2005; 65(19): 8818 - 8825.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Nilsson, R. H. Larsen, S. D. Fossa, L. Balteskard, K. W. Borch, J.-E. Westlin, G. Salberg, and O. S. Bruland
First Clinical Experience with {alpha}-Emitting Radium-223 in the Treatment of Skeletal Metastases
Clin. Cancer Res., June 15, 2005; 11(12): 4451 - 4459.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. Onuma, Y. Azuma, H. Saito, T. Tsunenari, T. Watanabe, M. Hirabayashi, K. Sato, H. Yamada-Okabe, and E. Ogata
Increased Renal Calcium Reabsorption by Parathyroid Hormone-Related Protein Is a Causative Factor in the Development of Humoral Hypercalcemia of Malignancy Refractory to Osteoclastic Bone Resorption Inhibitors
Clin. Cancer Res., June 1, 2005; 11(11): 4198 - 4203.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Tfelt-Hansen, N. Chattopadhyay, S. Yano, D. Kanuparthi, P. Rooney, P. Schwarz, and E. M. Brown
Calcium-Sensing Receptor Induces Proliferation through p38 Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase But Not Extracellularly Regulated Kinase in a Model of Humoral Hypercalcemia of Malignancy
Endocrinology, March 1, 2004; 145(3): 1211 - 1217.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Niida, M. Kawahara, Y. Ishizuka, Y. Ikeda, T. Kondo, T. Hibi, Y. Suzuki, K. Ikeda, and N. Taniguchi
{gamma}-Glutamyltranspeptidase Stimulates Receptor Activator of Nuclear Factor-{kappa}B Ligand Expression Independent of Its Enzymatic Activity and Serves as a Pathological Bone-resorbing Factor
J. Biol. Chem., February 13, 2004; 279(7): 5752 - 5756.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. Alvarez, M. Westmore, R. J. S. Galvin, C. L. Clapp, E. L. Considine, S. J. Smith, K. Keyes, P. W. Iversen, D. M. Delafuente, S. Sulaimon, et al.
Properties of Bisphosphonates in the 13762 Rat Mammary Carcinoma Model of Tumor-Induced Bone Resorption
Clin. Cancer Res., November 15, 2003; 9(15): 5705 - 5713.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
O. Peyruchaud, C.-M. Serre, R. NicAmhlaoibh, P. Fournier, and P. Clezardin
Angiostatin Inhibits Bone Metastasis Formation in Nude Mice through a Direct Anti-osteoclastic Activity
J. Biol. Chem., November 14, 2003; 278(46): 45826 - 45832.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. J. Yin, K. S. Mohammad, S. M. Kakonen, S. Harris, J. R. Wu-Wong, J. L. Wessale, R. J. Padley, I. R. Garrett, J. M. Chirgwin, and T. A. Guise
From the Cover: A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases
PNAS, September 16, 2003; 100(19): 10954 - 10959.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
M. J. Morris and H. I. Scher
Clinical Approaches to Osseous Metastases in Prostate Cancer
Oncologist, April 1, 2003; 8(2): 161 - 173.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. Fournier, S. Boissier, S. Filleur, J. Guglielmi, F. Cabon, M. Colombel, and P. Clezardin
Bisphosphonates Inhibit Angiogenesis in Vitro and Testosterone-stimulated Vascular Regrowth in the Ventral Prostate in Castrated Rats
Cancer Res., November 15, 2002; 62(22): 6538 - 6544.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Y. W. Bourguignon, P. A. Singleton, H. Zhu, and B. Zhou
Hyaluronan Promotes Signaling Interaction between CD44 and the Transforming Growth Factor beta Receptor I in Metastatic Breast Tumor Cells
J. Biol. Chem., October 11, 2002; 277(42): 39703 - 39712.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Abe, K. Hiura, J. Wilde, K. Moriyama, T. Hashimoto, S. Ozaki, S. Wakatsuki, M. Kosaka, S. Kido, D. Inoue, et al.
Role for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in the development of osteolytic lesions in multiple myeloma
Blood, August 28, 2002; 100(6): 2195 - 2202.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. L. Sanders, N. Chattopadhyay, O. Kifor, T. Yamaguchi, and E. M. Brown
Ca2+-sensing receptor expression and PTHrP secretion in PC-3 human prostate cancer cells
Am J Physiol Endocrinol Metab, December 1, 2001; 281(6): E1267 - E1274.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. O. Oyajobi, D. M. Anderson, K. Traianedes, P. J. Williams, T. Yoneda, and G. R. Mundy
Therapeutic Efficacy of a Soluble Receptor Activator of Nuclear Factor {{kappa}}B-IgG Fc Fusion Protein in Suppressing Bone Resorption and Hypercalcemia in a Model of Humoral Hypercalcemia of Malignancy
Cancer Res., March 1, 2001; 61(6): 2572 - 2578.
[Abstract] [Full Text]

Home page
 Physiol. Rev.Home page
E. M. Brown and R. J. MacLeod
Extracellular Calcium Sensing and Extracellular Calcium Signaling
Physiol Rev, January 1, 2001; 81(1): 239 - 297.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. L. Sanders, N. Chattopadhyay, O. Kifor, T. Yamaguchi, R. R. Butters, and E. M. Brown
Extracellular Calcium-Sensing Receptor Expression and Its Potential Role in Regulating Parathyroid Hormone-Related Peptide Secretion in Human Breast Cancer Cell Lines
Endocrinology, December 1, 2000; 141(12): 4357 - 4364.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Pederson, B. Winding, N. T. Foged, T. C. Spelsberg, and M. J. Oursler
Identification of Breast Cancer Cell Line-derived Paracrine Factors That Stimulate Osteoclast Activity
Cancer Res., November 1, 1999; 59(22): 5849 - 5855.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. J. Thomas, T. A. Guise, J. J. Yin, J. Elliott, N. J. Horwood, T. J. Martin, and M. T. Gillespie
Breast Cancer Cells Interact with Osteoblasts to Support Osteoclast Formation
Endocrinology, October 1, 1999; 140(10): 4451 - 4458.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
W. C. Dougall, M. Glaccum, K. Charrier, K. Rohrbach, K. Brasel, T. De Smedt, E. Daro, J. Smith, M. E. Tometsko, C. R. Maliszewski, et al.
RANK is essential for osteoclast and lymph node development
Genes & Dev., September 15, 1999; 13(18): 2412 - 2424.
[Abstract] [Full Text]

Home page
 Clin. Chem.Home page
L. M. Demers
Biochemical Markers in the Management of Patients with Metastatic Bone Disease
Clin. Chem., August 1, 1999; 45(8): 1131 - 1132.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. Berruti, L. Dogliotti, G. Gorzegno, M. Torta, M. Tampellini, M. Tucci, S. Cerutti, M. Mosca Frezet, M. Stivanello, G. Sacchetto, et al.
Differential Patterns of Bone Turnover in Relation to Bone Pain and Disease Extent in Bone in Cancer Patients with Skeletal Metastases
Clin. Chem., August 1, 1999; 45(8): 1240 - 1247.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1998 by The Endocrine Society