Roles of Circadian Rhythmicity and Sleep in Human Glucose Regulation1
Eve Van Cauter,
Kenneth S. Polonsky and
André J. Scheen
Department of Medicine, University of Chicago, Chicago, Illinois
60637; and Division of Diabetes, Nutrition and Metabolic Disorders,
University of Liège, Liège, Belgium B-4000
I. Introduction
II. Characteristics and Causal Mechanismsof 24-h Rhythms ofGlucose
Regulation in Normal Young Subjects
A. 24-h variations in glucose tolerance
B. Causal mechanisms
III. Alterations of 24-h Rhythms of Glucose Regulation inNormalAging
A. Daytime variations in glucose tolerance
B.Nighttime variations in glucose tolerance
C. Respective rolesof sleep and time of day
D. Significance and clinical implications
IV. Diurnal Variations of Glucose Regulation in Obesity
A.Daytime variations in glucose tolerance
B. Nighttime variationsin glucose tolerance
C. Significance and clinical implications
V. Alterations in 24-h Rhythmicity of Glucose Regulation in
Non-Insulin-DependentDiabetes Mellitus (NIDDM)
A. Alterations in daytime variationsin glucose tolerance
B. Alterations in nighttime variationsin glucose levels during
fasting
C. Significance and clinicalimplications
VI. Alterations in 24-h Rhythmicity of GlucoseRegulation in
Insulin-DependentDiabetes Mellitus (IDDM)
A.Alterations in daytime variations in glucose tolerance
B.Alterations in nighttime variations in glucose tolerance
C.Significance and clinical implications
VII. Conclusions
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