Molecular Genetics of Human Hypertension: Role of Angiotensinogen1
Pierre Corvol and
Xavier Jeunemaitre
INSERM U36, Collège de France, 75005 Paris, France
I. Introduction
II. Structure of the AGT Gene
III. Characteristicsof AGT
A. AGT as the substrate for renin
B. AGT as a memberof the serpin superfamily: other roles forAGT?
IV. Tissueand Cellular Distribution
V. Regulation
A. Hormonal regulationof AGT
B. Regulation of AGT in disease
C. Regulation ofAGT gene transcription
VI. Molecular Genetics of AGT in HumanEssential Hypertension
A. Strategies
B. Linkage studies
C. Association studies of AGT polymorphism and high bloodpressure
D. Pregnancy-induced hypertension
E. M235T variants,plasma AGT concentration, and blood pressure
F. Associationof AGT variants with the renal blood flow responseto Ang
IIinfusion
VII. Molecular Genetics of AGT and Other Diseases
A. AGT variants and coronary heart disease
B. AGT variantsand complications of diabetes
C. AGT, obesity, and blood pressure
VIII. Effects of AGT Gene Variants and Gene Targeting on AngI Production and
Blood Pressure
A. Human studies
B. Geneticstudies in rats and mice
C. Genetic hypertension in rats
D.Antisense AGT oligodeoxynucleotides
E. Transgenic animals
F. AGT gene duplication
IX. Conclusions and Perspectives
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