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Endocrine Reviews 18 (5): 646-661
Copyright © 1997 by The Endocrine Society

Catch-up Growth

Bart Boersma and Jan Maarten Wit

Department of Pediatrics, Leiden University Hospital, Leiden, The Netherlands

I. Introduction
II. Catch-up Growth: Theoretical Considerations
A. Definition
B. Catch-up growth vs. compensatory growth
C. Canalization
D. Catch-up growth vs. resumption of a normal height velocity
E. Types of catch-up growth
F. Assessment of duration and success of catch-up growth
III. Secondary Growth Disorders and Subsequent Catch-up Growth
A. The early studies
B. Malnutrition
C. Celiac disease
D. GH deficiency
E. Hypothyroidism
F. Corticosteroid excess
G. Intrauterine growth retardation (IUGR)
IV. Mechanisms Regulating Catch-up Growth
A. The neuroendocrine hypothesis
B. The growth plate hypothesis
V. Determinants of Normal Growth and Their Changes During Catch-up Growth
A. Introduction
B. The somatotrophic axis
C. The epiphyseal growth plate
VI. Concluding Remarks




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