Department of Pediatrics, Leiden University Hospital, Leiden, The
Netherlands
I. Introduction
II. Catch-up Growth: Theoretical Considerations
A. Definition
B. Catch-up growth vs. compensatory growth
C. Canalization
D. Catch-up growth vs. resumption of a normalheight
velocity
E. Types of catch-up growth
F. Assessmentof duration and success of catch-up growth
III. SecondaryGrowth Disorders and Subsequent Catch-up Growth
A. The earlystudies
B. Malnutrition
C. Celiac disease
D. GH deficiency
E. Hypothyroidism
F. Corticosteroid excess
G. Intrauterinegrowth retardation (IUGR)
IV. Mechanisms Regulating Catch-upGrowth
A. The neuroendocrine hypothesis
B. The growth platehypothesis
V. Determinants of Normal Growth and Their ChangesDuring Catch-upGrowth
A. Introduction
B. The somatotrophicaxis
C. The epiphyseal growth plate
VI. Concluding Remarks
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