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*Compound via MeSH
*Substance via MeSH
Endocrine Reviews 18 (5): 621-645
Copyright © 1997 by The Endocrine Society

Peptidomimetic Regulation of Growth Hormone Secretion

Roy G. Smith, Lex H. T. Van der Ploeg, Andrew D. Howard, Scott D. Feighner, Kang Cheng, Gerard J. Hickey, Matthew J. Wyvratt, Jr., Mike H. Fisher, Ravi P. Nargund and Arthur A. Patchett

Merck Research Laboratories, Rahway, New Jersey 07065

I. Introduction
II. Identification of Peptidomimetic GH Secretagogues
A. Mechanism of action of GHRH, GHRP-6, and somatostatin
B. In vitro assays
III. Molecular Design by Medicinal Chemistry
A. Benzolactams and L-692,429
B. Spiroindanes and MK-0677
C. Isonipecotic acid peptidomimetics
IV. Characterization of the MK-0677 Receptor
A. Pituitary gland
B. Hypothalamus
V. Signal Transduction Pathway
VI. Cloning the GH Secretagogue Receptor
A. Chromosomal localization
VII. Action of the Peptidomimetic GH Secretagogues in the Central Nervous System
VIII. Peptidomimetic GH Secretagogues in Vivo
A. Animal models
B. Clinical studies in humans
IX. Regulation of Pulsatile GH Release
A. GHRH and somatostatin
B. The role of GHS-R
X. Concluding Comments




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