help button home button Endocrine Society Endocrine Reviews
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Parker, K. L.
Right arrow Articles by Schimmer, B. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Parker, K. L.
Right arrow Articles by Schimmer, B. P.
Endocrine Reviews 18 (3): 361-377
Copyright © 1997 by The Endocrine Society

Steroidogenic Factor 1: A Key Determinant of Endocrine Development and Function

Keith L. Parker and Bernard P. Schimmer

Departments of Medicine and Pharmacology and the Howard Hughes Medical Institute (K.L.P.), Duke University Medical Center, Durham, North Carolina 27710; and the Banting and Best Department of Medical Research (B.P.S.), University of Toronto, Toronto, Canada M5G 1L6


I. Introduction
II. The Initial Identification of SF-1 as a Key Determinant of Steroid Hormone Biosynthesis
A. Overview of steroidogenesis
B. SF-1 and the regulation of steroidogenesis
C. Cloning and structural characterization of SF-1
1. Structural features of SF-1
2. Multiple transcripts are encoded by the gene encoding SF-1
3. The gene encoding SF-1 is evolutionarily conserved in vertebrates and invertebrates
III. Characterization of Sites of SF-1 Expression and Identification of Its Target Genes
A. Profiles of SF-1 expression
1. Adult steroidogenic tissues
2. Embryonic steroidogenic tissues
3. Other sites of SF-1 expression
B. Target genes regulated by SF-1
1. Steroidogenic cells
2. Sertoli cells
3. Gonadotropes
4. VMH
IV. The Roles Of SF-1 in Vivo: Targeted Gene Disruption to Create SF-1 Knockout Mice
A. General features of the SF-1 knockout mice
B. Primary steroidogenic tissues in SF-1 knockout mice
C. Pituitary and hypothalamic defects in SF-1 knockout mice
V. Perspectives and Future Directions
A. What are the roles of the various transcripts encoded by the Ftz-F1 gene?
B. Does a ligand mediate SF-1 transcriptional activation?
C. Where does SF-1 fit within hierarchical cascades of endocrine development?
1. Which other genes also contribute to tissue-selective expression of SF-1 target genes?
2. Which target genes of SF-1 mediate its key roles in maintaining the adrenal glands, gonads, and VMH?
3. What mechanisms regulate the expression of SF-1?
4. How is SF-1 related to other genes whose disruptions lead to phenotypes that resemble the SF-1 knockout mice?
D. Do other transcription factors/nuclear receptors serve dual roles in development and maintenance of the differentiated phenotype?
VI. Conclusion




This article has been cited by other articles:


Home page
 Integr. Comp. Biol.Home page
N. Valenzuela
Evolution of the gene network underlying gonadogenesis in turtles with temperature-dependent and genotypic sex determination
Integr. Comp. Biol., May 13, 2008; (2008) icn031v1.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
P. S. H. Soon, K. L. McDonald, B. G. Robinson, and S. B. Sidhu
Molecular Markers and the Pathogenesis of Adrenocortical Cancer
Oncologist, May 1, 2008; 13(5): 548 - 561.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
H. Utsunomiya, Y.-H. Cheng, Z. Lin, S. Reierstad, P. Yin, E. Attar, Q. Xue, G. Imir, S. Thung, E. Trukhacheva, et al.
Upstream Stimulatory Factor-2 Regulates Steroidogenic Factor-1 Expression in Endometriosis
Mol. Endocrinol., April 1, 2008; 22(4): 904 - 914.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Yazawa, M. Uesaka, Y. Inaoka, T. Mizutani, T. Sekiguchi, T. Kajitani, T. Kitano, A. Umezawa, and K. Miyamoto
Cyp11b1 Is Induced in the Murine Gonad by Luteinizing Hormone/Human Chorionic Gonadotropin and Involved in the Production of 11-Ketotestosterone, a Major Fish Androgen: Conservation and Evolution of the Androgen Metabolic Pathway
Endocrinology, April 1, 2008; 149(4): 1786 - 1792.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
A. L. Del Tredici, C. B. Andersen, E. A. Currier, S. R. Ohrmund, L. C. Fairbain, B. W. Lund, N. Nash, R. Olsson, and F. Piu
Identification of the First Synthetic Steroidogenic Factor 1 Inverse Agonists: Pharmacological Modulation of Steroidogenic Enzymes
Mol. Pharmacol., March 1, 2008; 73(3): 900 - 908.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Fukami, Y. Wada, M. Okada, F. Kato, N. Katsumata, T. Baba, K.-i. Morohashi, J. Laporte, M. Kitagawa, and T. Ogata
Mastermind-like Domain-containing 1 (MAMLD1 or CXorf6) Transactivates the Hes3 Promoter, Augments Testosterone Production, and Contains the SF1 Target Sequence
J. Biol. Chem., February 29, 2008; 283(9): 5525 - 5532.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
T. Tanaka, S. Gondo, T. Okabe, K. Ohe, H. Shirohzu, H. Morinaga, M. Nomura, K. Tani, R. Takayanagi, H. Nawata, et al.
Steroidogenic factor 1/adrenal 4 binding protein transforms human bone marrow mesenchymal cells into steroidogenic cells
J. Mol. Endocrinol., November 1, 2007; 39(5): 343 - 350.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
W.-Y. Chen, J.-H. Weng, C.-C. Huang, and B.-c. Chung
Histone Deacetylase Inhibitors Reduce Steroidogenesis through SCF-Mediated Ubiquitination and Degradation of Steroidogenic Factor 1 (NR5A1)
Mol. Cell. Biol., October 15, 2007; 27(20): 7284 - 7290.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
A. L Reuter, K. Goji, N. C Bingham, M. Matsuo, and K. L Parker
A novel mutation in the accessory DNA-binding domain of human steroidogenic factor 1 causes XY gonadal dysgenesis without adrenal insufficiency
Eur. J. Endocrinol., August 1, 2007; 157(2): 233 - 238.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. Coutant, D. Mallet, N. Lahlou, N. Bouhours-Nouet, A. Guichet, L. Coupris, A. Croue, and Y. Morel
Heterozygous Mutation of Steroidogenic Factor-1 in 46,XY Subjects May Mimic Partial Androgen Insensitivity Syndrome
J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 2868 - 2873.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
Q. Xue, Z. Lin, P. Yin, M. P. Milad, Y.-H. Cheng, E. Confino, S. Reierstad, and S. E. Bulun
Transcriptional Activation of Steroidogenic Factor-1 by Hypomethylation of the 5' CpG Island in Endometriosis
J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 3261 - 3267.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
H.-C. Lan, H.-J. Li, G. Lin, P.-Y. Lai, and B.-c. Chung
Cyclic AMP Stimulates SF-1-Dependent CYP11A1 Expression through Homeodomain-Interacting Protein Kinase 3-Mediated Jun N-Terminal Kinase and c-Jun Phosphorylation
Mol. Cell. Biol., March 15, 2007; 27(6): 2027 - 2036.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. Lin, P. Philibert, B. Ferraz-de-Souza, D. Kelberman, T. Homfray, A. Albanese, V. Molini, N. J. Sebire, S. Einaudi, G. S. Conway, et al.
Heterozygous Missense Mutations in Steroidogenic Factor 1 (SF1/Ad4BP, NR5A1) Are Associated with 46,XY Disorders of Sex Development with Normal Adrenal Function
J. Clin. Endocrinol. Metab., March 1, 2007; 92(3): 991 - 999.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. V. Patchev, D. Fischer, S. S. Wolf, M. Herkenham, F. Gotz, M. Gehin, P. Chambon, V. K. Patchev, and O. F. X. Almeida
Insidious adrenocortical insufficiency underlies neuroendocrine dysregulation in TIF-2 deficient mice
FASEB J, January 1, 2007; 21(1): 231 - 238.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
T. Sugawara, N. Sakuragi, and H. Minakami
CREM confers cAMP responsiveness in human steroidogenic acute regulatory protein expression in NCI-H295R cells rather than SF-1/Ad4BP.
J. Endocrinol., October 1, 2006; 191(1): 327 - 337.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
A. K. Iyer, Y.-H. Zhang, and E. R. B. McCabe
Dosage-Sensitive Sex Reversal Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1 (DAX1) (NR0B1) and Small Heterodimer Partner (SHP) (NR0B2) Form Homodimers Individually, as Well as DAX1-SHP Heterodimers
Mol. Endocrinol., October 1, 2006; 20(10): 2326 - 2342.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Yazawa, T. Mizutani, K. Yamada, H. Kawata, T. Sekiguchi, M. Yoshino, T. Kajitani, Z. Shou, A. Umezawa, and K. Miyamoto
Differentiation of Adult Stem Cells Derived from Bone Marrow Stroma into Leydig or Adrenocortical Cells
Endocrinology, September 1, 2006; 147(9): 4104 - 4111.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. Lin, W.-X. Gu, G. Ozisik, W. S. To, C. J. Owen, J. L. Jameson, and J. C. Achermann
Analysis of DAX1 (NR0B1) and Steroidogenic Factor-1 (NR5A1) in Children and Adults with Primary Adrenal Failure: Ten Years' Experience
J. Clin. Endocrinol. Metab., August 1, 2006; 91(8): 3048 - 3054.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K.-H. Song, Y.-Y. Park, H. J. Kee, C. Y. Hong, Y.-S. Lee, S.-W. Ahn, H.-J. Kim, K. Lee, H. Kook, I.-K. Lee, et al.
Orphan Nuclear Receptor Nur77 Induces Zinc Finger Protein GIOT-1 Gene Expression, and GIOT-1 Acts as a Novel Corepressor of Orphan Nuclear Receptor SF-1 via Recruitment of HDAC2
J. Biol. Chem., June 9, 2006; 281(23): 15605 - 15614.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. P. Schimmer, M. Cordova, H. Cheng, A. Tsao, A. B. Goryachev, A. D. Schimmer, and Q. Morris
Global Profiles of Gene Expression Induced by Adrenocorticotropin in Y1 Mouse Adrenal Cells
Endocrinology, May 1, 2006; 147(5): 2357 - 2367.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. D. Veldhuis, J. N. Roemmich, E. J. Richmond, and C. Y. Bowers
Somatotropic and Gonadotropic Axes Linkages in Infancy, Childhood, and the Puberty-Adult Transition
Endocr. Rev., April 1, 2006; 27(2): 101 - 140.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. Ragazzon, A.-M. Lefrancois-Martinez, P. Val, I. Sahut-Barnola, C. Tournaire, C. Chambon, J.-L. Gachancard-Bouya, R.-J. Begue, G. Veyssiere, and A. Martinez
Adrenocorticotropin-Dependent Changes in SF-1/DAX-1 Ratio Influence Steroidogenic Genes Expression in a Novel Model of Glucocorticoid-Producing Adrenocortical Cell Lines Derived from Targeted Tumorigenesis
Endocrinology, April 1, 2006; 147(4): 1805 - 1818.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. Safi, A. Kovacic, S. Gaillard, Y. Murata, E. R. Simpson, D. P. McDonnell, and C. D. Clyne
Coactivation of Liver Receptor Homologue-1 by Peroxisome Proliferator-Activated Receptor {gamma} Coactivator-1{alpha} on Aromatase Promoter II and Its Inhibition by Activated Retinoid X Receptor Suggest a Novel Target for Breast-Specific Antiestrogen Therapy
Cancer Res., December 15, 2005; 65(24): 11762 - 11770.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
T. Suzuki, Y. Miki, Y. Nakamura, T. Moriya, K. Ito, N. Ohuchi, and H. Sasano
Sex steroid-producing enzymes in human breast cancer
Endocr. Relat. Cancer, December 1, 2005; 12(4): 701 - 720.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
W.-Y. Chen, L.-J. Juan, and B.-c. Chung
SF-1 (Nuclear Receptor 5A1) Activity Is Activated by Cyclic AMP via p300-Mediated Recruitment to Active Foci, Acetylation, and Increased DNA Binding
Mol. Cell. Biol., December 1, 2005; 25(23): 10442 - 10453.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
Y. Shima, M. Zubair, S. Ishihara, Y. Shinohara, S. Oka, S. Kimura, S. Okamoto, Y. Minokoshi, S. Suita, and K.-i. Morohashi
Ventromedial Hypothalamic Nucleus-Specific Enhancer of Ad4BP/SF-1 Gene
Mol. Endocrinol., November 1, 2005; 19(11): 2812 - 2823.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M.-C. Battista, M. Otis, M. Cote, A. Laforest, M. Peter, E. Lalli, and N. Gallo-Payet
Extracellular Matrix and Hormones Modulate DAX-1 Localization in the Human Fetal Adrenal Gland
J. Clin. Endocrinol. Metab., September 1, 2005; 90(9): 5426 - 5431.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
N. Huang, A. Dardis, and W. L. Miller
Regulation of Cytochrome b5 Gene Transcription by Sp3, GATA-6, and Steroidogenic Factor 1 in Human Adrenal NCI-H295A Cells
Mol. Endocrinol., August 1, 2005; 19(8): 2020 - 2034.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
A. Bavner, J. Matthews, S. Sanyal, J.-A. Gustafsson, and E. Treuter
EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation
Nucleic Acids Res., June 24, 2005; 33(11): 3561 - 3569.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W. Wang, C. Zhang, A. Marimuthu, H. I. Krupka, M. Tabrizizad, R. Shelloe, U. Mehra, K. Eng, H. Nguyen, C. Settachatgul, et al.
The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1
PNAS, May 24, 2005; 102(21): 7505 - 7510.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
O. Zwermann, F. Beuschlein, E. Lalli, A. Klink, P. Sassone-Corsi, and M. Reincke
Clinical and molecular evidence for DAX-1 inhibition of steroidogenic factor-1-dependent ACTH receptor gene expression
Eur. J. Endocrinol., May 1, 2005; 152(5): 769 - 776.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. P. Segal, N. R. Stallings, C. E. Lee, L. Zhao, N. Socci, A. Viale, T. M. Harris, M. B. Soares, G. Childs, J. K. Elmquist, et al.
Use of Laser-Capture Microdissection for the Identification of Marker Genes for the Ventromedial Hypothalamic Nucleus
J. Neurosci., April 20, 2005; 25(16): 4181 - 4188.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. B. Lee, L. A. Lebedeva, M. Suzawa, S. A. Wadekar, M. Desclozeaux, and H. A. Ingraham
The DEAD-Box Protein DP103 (Ddx20 or Gemin-3) Represses Orphan Nuclear Receptor Activity via SUMO Modification
Mol. Cell. Biol., March 1, 2005; 25(5): 1879 - 1890.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. W. Kim, J. C. Havelock, B. R. Carr, and G. R. Attia
The Orphan Nuclear Receptor, Liver Receptor Homolog-1, Regulates Cholesterol Side-Chain Cleavage Cytochrome P450 Enzyme in Human Granulosa Cells
J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1678 - 1685.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
N. Huang and W. L. Miller
LBP Proteins Modulate SF1-Independent Expression of P450scc in Human Placental JEG-3 Cells
Mol. Endocrinol., February 1, 2005; 19(2): 409 - 420.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
B. C. Figueiredo, L. R. Cavalli, M. A. D. Pianovski, E. Lalli, R. Sandrini, R. C. Ribeiro, G. Zambetti, L. DeLacerda, G. A. Rodrigues, and B. R. Haddad
Amplification of the Steroidogenic Factor 1 Gene in Childhood Adrenocortical Tumors
J. Clin. Endocrinol. Metab., February 1, 2005; 90(2): 615 - 619.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. M. Bastida, A. Cremades, M. T. Castells, A. J. Lopez-Contreras, C. Lopez-Garcia, F. Tejada, and R. Penafiel
Influence of Ovarian Ornithine Decarboxylase in Folliculogenesis and Luteinization
Endocrinology, February 1, 2005; 146(2): 666 - 674.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. Silhankova, M. Jindra, and M. Asahina
Nuclear receptor NHR-25 is required for cell-shape dynamics during epidermal differentiation in Caenorhabditis elegans
J. Cell Sci., January 1, 2005; 118(1): 223 - 232.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
J Liu, X-D Li, A Vaheri, and R Voutilainen
DNA methylation affects cell proliferation, cortisol secretion and steroidogenic gene expression in human adrenocortical NCI-H295R cells
J. Mol. Endocrinol., December 1, 2004; 33(3): 651 - 662.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. Hasegawa, M. Fukami, N. Sato, N. Katsumata, G. Sasaki, K. Fukutani, K.-I. Morohashi, and T. Ogata
Testicular Dysgenesis without Adrenal Insufficiency in a 46,XY Patient with a Heterozygous Inactive Mutation of Steroidogenic Factor-1
J. Clin. Endocrinol. Metab., December 1, 2004; 89(12): 5930 - 5935.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
A. H. Payne and D. B. Hales
Overview of Steroidogenic Enzymes in the Pathway from Cholesterol to Active Steroid Hormones
Endocr. Rev., December 1, 2004; 25(6): 947 - 970.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Cherian-Shaw, R. Das, C. A. VandeVoort, and C. L. Chaffin
Regulation of Steroidogenesis by p53 in Macaque Granulosa Cells and H295R Human Adrenocortical Cells
Endocrinology, December 1, 2004; 145(12): 5734 - 5744.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
S. Gondo, T. Yanase, T. Okabe, T. Tanaka, H. Morinaga, M. Nomura, K. Goto, and H. Nawata
SF-1/Ad4BP transforms primary long-term cultured bone marrow cells into ACTH-responsive steroidogenic cells
Genes Cells, December 1, 2004; 9(12): 1239 - 1247.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W.-Y. Chen, W.-C. Lee, N.-C. Hsu, F. Huang, and B.-c. Chung
SUMO Modification of Repression Domains Modulates Function of Nuclear Receptor 5A1 (Steroidogenic Factor-1)
J. Biol. Chem., September 10, 2004; 279(37): 38730 - 38735.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Cui, A. Ross, N. Stallings, K. L. Parker, B. Capel, and S. E. Quaggin
Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice
Development, August 15, 2004; 131(16): 4095 - 4105.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. S. Jorgensen, C. C. Quirk, and J. H. Nilson
Multiple and Overlapping Combinatorial Codes Orchestrate Hormonal Responsiveness and Dictate Cell-Specific Expression of the Genes Encoding Luteinizing Hormone
Endocr. Rev., August 1, 2004; 25(4): 521 - 542.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Saxena, R. Safi, L. Little-Ihrig, and A. J. Zeleznik
Liver Receptor Homolog-1 Stimulates the Progesterone Biosynthetic Pathway during Follicle-Stimulating Hormone-Induced Granulosa Cell Differentiation
Endocrinology, August 1, 2004; 145(8): 3821 - 3829.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. L. Britt, P. G. Stanton, M. Misso, E. R. Simpson, and J. K. Findlay
The Effects of Estrogen on the Expression of Genes Underlying the Differentiation of Somatic Cells in the Murine Gonad
Endocrinology, August 1, 2004; 145(8): 3950 - 3960.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Suzuki, Y. Miki, T. Moriya, N. Shimada, T. Ishida, H. Hirakawa, N. Ohuchi, and H. Sasano
Estrogen-Related Receptor {alpha} in Human Breast Carcinoma as a Potent Prognostic Factor
Cancer Res., July 1, 2004; 64(13): 4670 - 4676.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
P. Jeyasuria, Y. Ikeda, S. P. Jamin, L. Zhao, D. G. de Rooij, A. P. N. Themmen, R. R. Behringer, and K. L. Parker
Cell-Specific Knockout of Steroidogenic Factor 1 Reveals Its Essential Roles in Gonadal Function
Mol. Endocrinol., July 1, 2004; 18(7): 1610 - 1619.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A.-M. Lefrancois-Martinez, J. Bertherat, P. Val, C. Tournaire, N. Gallo-Payet, D. Hyndman, G. Veyssiere, X. Bertagna, C. Jean, and A. Martinez
Decreased Expression of Cyclic Adenosine Monophosphate-Regulated Aldose Reductase (AKR1B1) Is Associated with Malignancy in Human Sporadic Adrenocortical Tumors
J. Clin. Endocrinol. Metab., June 1, 2004; 89(6): 3010 - 3019.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. W. Kim, N. Peng, W. E. Rainey, B. R. Carr, and G. R. Attia
Liver Receptor Homolog-1 Regulates the Expression of Steroidogenic Acute Regulatory Protein in Human Granulosa Cells
J. Clin. Endocrinol. Metab., June 1, 2004; 89(6): 3042 - 3047.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. A. Noon, A. J. L. Clark, and P. J. King
A Peroxisome Proliferator-response Element in the Murine mc2-r Promoter Regulates Its Transcriptional Activation during Differentiation of 3T3-L1 Adipocytes
J. Biol. Chem., May 28, 2004; 279(22): 22803 - 22808.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Kajitani, T. Mizutani, K. Yamada, T. Yazawa, T. Sekiguchi, M. Yoshino, H. Kawata, and K. Miyamoto
Cloning and Characterization of Granulosa Cell High-Mobility Group (HMG)-Box Protein-1, a Novel HMG-Box Transcriptional Regulator Strongly Expressed in Rat Ovarian Granulosa Cells
Endocrinology, May 1, 2004; 145(5): 2307 - 2318.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. Y. Hong, J. H. Park, R. S. Ahn, S. Y. Im, H.-S. Choi, J. Soh, S. H. Mellon, and K. Lee
Molecular Mechanism of Suppression of Testicular Steroidogenesis by Proinflammatory Cytokine Tumor Necrosis Factor Alpha
Mol. Cell. Biol., April 1, 2004; 24(7): 2593 - 2604.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. L. Bland, R. C. Fowkes, and H. A. Ingraham
Differential Requirement for Steroidogenic Factor-1 Gene Dosage in Adrenal Development Versus Endocrine Function
Mol. Endocrinol., April 1, 2004; 18(4): 941 - 952.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
T. Fayad, V. Levesque, J. Sirois, D. W. Silversides, and J. G. Lussier
Gene Expression Profiling of Differentially Expressed Genes in Granulosa Cells of Bovine Dominant Follicles Using Suppression Subtractive Hybridization
Biol Reprod, February 1, 2004; 70(2): 523 - 533.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
W. Fan, T. Yanase, Y. Wu, H. Kawate, M. Saitoh, K. Oba, M. Nomura, T. Okabe, K. Goto, J. Yanagisawa, et al.
Protein Kinase A Potentiates Adrenal 4 Binding Protein/Steroidogenic Factor 1 Transactivation by Reintegrating the Subcellular Dynamic Interactions of the Nuclear Receptor with Its Cofactors, General Control Nonderepressed-5/Transformation/ Transcription Domain-Associated Protein, and Suppressor, Dosage-Sensitive Sex Reversal-1: a Laser Confocal Imaging Study in Living KGN Cells
Mol. Endocrinol., January 1, 2004; 18(1): 127 - 141.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
A. P. ARNOLD, E. F. RISSMAN, and G. J. DE VRIES
Two Perspectives on the Origin of Sex Differences in the Brain
Ann. N.Y. Acad. Sci., December 1, 2003; 1007(1): 176 - 188.
[Abstract] [Full Text] [PDF]

Home page