Chick Ovalbumin Upstream Promoter-Transcription Factors (COUP-TFs): Coming of Age1
Sophia Y. Tsai and
Ming-Jer Tsai
Department of Cell Biology (S.Y.T., M-J.T.) and Medicine (M-J.T.),
Baylor College of Medicine, Houston, Texas 77030
I. Introduction
II. The COUP-TF Gene Family
A. Homologyto other members of the steroid/thyroid hormonereceptor
superfamily
B. Sequence homology within the COUP-TF gene family
III.Biochemical Characteristics
A. DNA-binding sites
B. Molecularmechanism of COUP-TFs action
1. Competition for occupancyof the binding sites
2. Competition for RXR
3. Active repression
4. Transrepression
5. The role of COUP-TFs in transactivation
IV. Expression Patterns of COUP-TFs During Development
A.Expression patterns in zebrafish and Xenopus
B. Expressionpatterns in mouse and chick
V. Physiological Function of COUP-TFs
A. Ectopic expression of svp in Drosophila
B. Ectopic expressionof COUP-TFI in Xenopus embryos
C. Loss of function of COUP-TFIin mice
D. Loss of function of COUP-TFII in mice
VI. Regulationof the Expression of COUP-TF Genes
A. Regulation of COUP-TFby retinoids
B. Regulation of COUP-TF by sonic hedgehog (Shh)
VII. Perspectives
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