Department of Cardiovascular Research, Genentech, Inc., South San
Francisco, California 94080
I. Introduction
II. Biological Activities of VEGF
III. Organizationof the VEGF Gene
IV. Properties of the VEGF Isoforms
V.Regulation of VEGF Gene Expression
A. Hypoxia
B. Cytokines
C. Differentiation and transformation
VI. The VEGF Receptors
A. Characterization and distribution of VEGF-binding sites
B. The Flt-1 and Flk-1/KDR tyrosine kinases
1. Binding characteristics
2. Signal transduction
3. Regulation
4. Structural requirementsfor ligand binding in Flt-1 and Flk-1/KDR
5. VEGF determinantsfor binding Flt-1 and Flk-1/KDR
VII. VEGF-Related Molecules
VIII. Role of VEGF and Its Receptors in Physiological Angiogenesis
A. Distribution of VEGF, Flk-1/KDR and Flt-1 mRNA
B. Analysisof Flk-1/KDR, Flt-1 and VEGF gene knockouts
IX. Role of VEGFin Pathological Angiogenesis
A. Tumor angiogenesis
1. Expressionof VEGF in human tumors
2. Inhibition of VEGF action in vivo
B. Intraocular neovascular syndromes
C. Other pathologicalconditions
X. Therapeutic Applications of VEGF-Induced Angiogenesis
XI. Perspectives
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X. Hao, E. A. Silva, A. Mansson-Broberg, K.-H. Grinnemo, A. J. Siddiqui, G. Dellgren, E. Wardell, L. A. Brodin, D. J. Mooney, and C. Sylven Angiogenic effects of sequential release of VEGF-A165 and PDGF-BB with alginate hydrogels after myocardial infarction
Cardiovasc Res,
July 1, 2007;
75(1):
178 - 185.
[Abstract][Full Text][PDF]
Z.-M. Bian, S. G. Elner, and V. M. Elner Thrombin-Induced VEGF Expression in Human Retinal Pigment Epithelial Cells
Invest. Ophthalmol. Vis. Sci.,
June 1, 2007;
48(6):
2738 - 2746.
[Abstract][Full Text][PDF]
J Sengupta, P G L Lalitkumar, A R Najwa, D S Charnock-Jones, A L Evans, A M Sharkey, S K Smith, and D Ghosh Immunoneutralization of vascular endothelial growth factor inhibits pregnancy establishment in the rhesus monkey (Macaca mulatta)
Reproduction,
June 1, 2007;
133(6):
1199 - 1211.
[Abstract][Full Text][PDF]
R. P.M. Dings, M. Loren, H. Heun, E. McNiel, A. W. Griffioen, K. H. Mayo, and R. J. Griffin Scheduling of Radiation with Angiogenesis Inhibitors Anginex and Avastin Improves Therapeutic Outcome via Vessel Normalization
Clin. Cancer Res.,
June 1, 2007;
13(11):
3395 - 3402.
[Abstract][Full Text][PDF]
J. D. Hainsworth, D. R. Spigel, C. Farley, D. S. Thompson, D. L. Shipley, and F. A. Greco Phase II Trial of Bevacizumab and Erlotinib in Carcinomas of Unknown Primary Site: The Minnie Pearl Cancer Research Network
J. Clin. Oncol.,
May 1, 2007;
25(13):
1747 - 1752.
[Abstract][Full Text][PDF]
R. R. Langley and I. J. Fidler Tumor Cell-Organ Microenvironment Interactions in the Pathogenesis of Cancer Metastasis
Endocr. Rev.,
May 1, 2007;
28(3):
297 - 321.
[Abstract][Full Text][PDF]
V L Bosquiazzo, J G Ramos, J Varayoud, M Munoz-de-Toro, and E H Luque Mast cell degranulation in rat uterine cervix during pregnancy correlates with expression of vascular endothelial growth factor mRNA and angiogenesis
Reproduction,
May 1, 2007;
133(5):
1045 - 1055.
[Abstract][Full Text][PDF]
S. M. Meeran, S. Katiyar, C. A. Elmets, and S. K. Katiyar Interleukin-12 Deficiency Is Permissive for Angiogenesis in UV Radiation-Induced Skin Tumors
Cancer Res.,
April 15, 2007;
67(8):
3785 - 3793.
[Abstract][Full Text][PDF]
D. Kong, Y. Li, Z. Wang, S. Banerjee, and F. H. Sarkar Inhibition of Angiogenesis and Invasion by 3,3'-Diindolylmethane Is Mediated by the Nuclear Factor-{kappa}B Downstream Target Genes MMP-9 and uPA that Regulated Bioavailability of Vascular Endothelial Growth Factor in Prostate Cancer
Cancer Res.,
April 1, 2007;
67(7):
3310 - 3319.
[Abstract][Full Text][PDF]
J. Fang, Q. Zhou, L.-Z. Liu, C. Xia, X. Hu, X. Shi, and B.-H. Jiang Apigenin inhibits tumor angiogenesis through decreasing HIF-1{alpha} and VEGF expression
Carcinogenesis,
April 1, 2007;
28(4):
858 - 864.
[Abstract][Full Text][PDF]
S. Jesmin, S. Zaedi, N. Shimojo, M. Iemitsu, K. Masuzawa, N. Yamaguchi, C. N. Mowa, S. Maeda, Y. Hattori, and T. Miyauchi Endothelin antagonism normalizes VEGF signaling and cardiac function in STZ-induced diabetic rat hearts
Am J Physiol Endocrinol Metab,
April 1, 2007;
292(4):
E1030 - E1040.
[Abstract][Full Text][PDF]
M. J. Nijland, N. E. Schlabritz-Loutsevitch, G. B. Hubbard, P. W. Nathanielsz, and L. A. Cox Non-human primate fetal kidney transcriptome analysis indicates mammalian target of rapamycin (mTOR) is a central nutrient-responsive pathway
J. Physiol.,
March 15, 2007;
579(3):
643 - 656.
[Abstract][Full Text][PDF]
M. Buraczynska, P. Ksiazek, I. Baranowicz-Gaszczyk, and L. Jozwiak Association of the VEGF gene polymorphism with diabetic retinopathy in type 2 diabetes patients
Nephrol. Dial. Transplant.,
March 1, 2007;
22(3):
827 - 832.
[Abstract][Full Text][PDF]
J. A. Garcia and B. I. Rini Recent Progress in the Management of Advanced Renal Cell Carcinoma
CA Cancer J Clin,
March 1, 2007;
57(2):
112 - 125.
[Abstract][Full Text][PDF]
Y. Li, S. Hazarika, D. Xie, A. M. Pippen, C. D. Kontos, and B. H. Annex In Mice With Type 2 Diabetes, a Vascular Endothelial Growth Factor (VEGF)-Activating Transcription Factor Modulates VEGF Signaling and Induces Therapeutic Angiogenesis After Hindlimb Ischemia
Diabetes,
March 1, 2007;
56(3):
656 - 665.
[Abstract][Full Text][PDF]
D. Manau, F. Fabregues, J. Penarrubia, M. Creus, F. Carmona, G. Casals, W. Jimenez, and J. Balasch Vascular endothelial growth factor levels in serum and plasma from patients undergoing controlled ovarian hyperstimulation for IVF
Hum. Reprod.,
March 1, 2007;
22(3):
669 - 675.
[Abstract][Full Text][PDF]
