Andreas Bikfalvi,
Sharon Klein,
Giuseppe Pintucci and
Daniel B. Rifkin
Department of Cell Biology (S.K., G.P), and the Raymond and Beverly
Sackler Foundation Laboratory (D.B.R.), and the Kaplan Cancer Center,
New York University Medical Center, New York, New York 10016; and the
Growth Factor and Cell Differentiation Laboratory (A.B.), University of
Bordeaux I, 33405 Talence, France
I. Introduction
II. Structure of FGF-2
III. Mechanisms ofAction of FGF-2: Extra- and IntracellularSignaling
A. Exogenous18-kDa FGF-2
B. Endogenous 18-kDa FGF-2 and HMW FGF-2
IV.Release of FGF-2
V. Roles of FGF-2 in Development and Differentiationin VariousOrgan
Systems
A. Mesoderm induction
B. Angiogenesis
C. Vessel wall
D. Lung
E. Hematopoiesis
F. Nervous system
G. Reproductive system
H. Skin
I. Eye
J. Muscle andskeleton
K. Digestive system
VI. Conclusions
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C. J. Sullivan and J. B. Hoying Flow-Dependent Remodeling in the Carotid Artery of Fibroblast Growth Factor-2 Knockout Mice
Arterioscler Thromb Vasc Biol,
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H. Kubo, R. Cao, E. Brakenhielm, T. Makinen, Y. Cao, and K. Alitalo Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea
PNAS,
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O. Devuyst New insights in the molecular mechanisms regulating peritoneal permeability
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T. Shimoaka, T. Ogasawara, A. Yonamine, D. Chikazu, H. Kawano, K. Nakamura, N. Itoh, and H. Kawaguchi Regulation of Osteoblast, Chondrocyte, and Osteoclast Functions by Fibroblast Growth Factor (FGF)-18 in Comparison with FGF-2 and FGF-10
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J. T. A. Meij, F. Sheikh, S. K. Jimenez, P. W. Nickerson, E. Kardami, and P. A. Cattini Exacerbation of myocardial injury in transgenic mice overexpressing FGF-2 is T cell dependent
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E. Tassi, A. Al-Attar, A. Aigner, M. R. Swift, K. McDonnell, A. Karavanov, and A. Wellstein Enhancement of Fibroblast Growth Factor (FGF) Activity by an FGF-binding Protein
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M. Aihara, J. D. Lindsey, and R. N. Weinreb Enhanced FGF-2 Movement through Human Sclera after Exposure to Latanoprost
Invest. Ophthalmol. Vis. Sci.,
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S. COMBET, M.-L. FERRIER, M. V. LANDSCHOOT, M. STOENOIU, P. MOULIN, T. MIYATA, N. LAMEIRE, and O. DEVUYST Chronic Uremia Induces Permeability Changes, Increased Nitric Oxide Synthase Expression, and Structural Modifications in the Peritoneum
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A. Jozkowicz, J. P Cooke, I. Guevara, I. Huk, P. Funovics, O. Pachinger, F. Weidinger, and J. Dulak Genetic augmentation of nitric oxide synthase increases the vascular generation of VEGF
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K. Reimers, M. Antoine, M. Zapatka, V. Blecken, C. Dickson, and P. Kiefer NoBP, a Nuclear Fibroblast Growth Factor 3 Binding Protein, Is Cell Cycle Regulated and Promotes Cell Growth
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M. Yokoyama and T. Hirase Harmonic Interplay of Angiogenic Growth Factors in the Development of Coronary Blood Vessels
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R. ROSENTHAL, H. THIEME, and O. STRAUSS Fibroblast growth factor receptor 2 (FGFR2) in brain neurons and retinal pigment epithelial cells act via stimulation of neuroendocrine L-type channels (Cav1.3)
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H. Naora, Y. Yang, F. J. Montz, J. D. Seidman, R. J. Kurman, and R. B. S. Roden A serologically identified tumor antigen encoded by a homeobox gene promotes growth of ovarian epithelial cells
PNAS,
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J. F. Reilly and P. A. Maher Importin {beta}-Mediated Nuclear Import of Fibroblast Growth Factor Receptor: Role in Cell Proliferation
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C. Berking, R. Takemoto, K. Satyamoorthy, R. Elenitsas, and M. Herlyn Basic Fibroblast Growth Factor and Ultraviolet B Transform Melanocytes in Human Skin
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F. Sheikh, D. P. Sontag, R. R. Fandrich, E. Kardami, and P. A. Cattini Overexpression of FGF-2 increases cardiac myocyte viability after injury in isolated mouse hearts
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P. Auguste, D. B. Gürsel, S. Lemière, D. Reimers, P. Cuevas, F. Carceller, J. P. Di Santo, and A. Bikfalvi Inhibition of Fibroblast Growth Factor/Fibroblast Growth Factor Receptor Activity in Glioma Cells Impedes Tumor Growth by Both Angiogenesis-dependent and -independent Mechanisms
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G Deutsch, J Jung, M Zheng, J Lora, and K. Zaret A bipotential precursor population for pancreas and liver within the embryonic endoderm
Development,
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A. Parenti, L. Brogelli, S. Donnini, M. Ziche, and F. Ledda ANG II potentiates mitogenic effect of norepinephrine in vascular muscle cells: role of FGF-2
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P. Salven, A. Orpana, L. Teerenhovi, and H. Joensuu Simultaneous elevation in the serum concentrations of the angiogenic growth factors VEGF and bFGF is an independent predictor of poor prognosis in non-Hodgkin lymphoma: a single-institution study of 200 patients
Blood,
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L. Van den Berghe, H. Laurell, I. Huez, C. Zanibellato, H. Prats, and B. Bugler FIF [Fibroblast Growth Factor-2 (FGF-2)-Interacting-Factor], a Nuclear Putatively Antiapoptotic Factor, Interacts Specifically with FGF-2
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[Abstract][Full Text]
