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Biological Roles of Fibroblast Growth Factor-2¹

Department of Cell Biology (S.K., G.P), and the Raymond and Beverly Sackler Foundation Laboratory (D.B.R.), and the Kaplan Cancer Center, New York University Medical Center, New York, New York 10016; and the Growth Factor and Cell Differentiation Laboratory (A.B.), University of Bordeaux I, 33405 Talence, France

I. Introduction

II. Structure of FGF-2

III. Mechanisms of Action of FGF-2: Extra- and Intracellular Signaling

A. Exogenous 18-kDa FGF-2

B. Endogenous 18-kDa FGF-2 and HMW FGF-2

IV. Release of FGF-2

V. Roles of FGF-2 in Development and Differentiation in Various Organ Systems

A. Mesoderm induction

B. Angiogenesis

C. Vessel wall

D. Lung

E. Hematopoiesis

F. Nervous system

G. Reproductive system

H. Skin

I. Eye

J. Muscle and skeleton

K. Digestive system

VI. Conclusions

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