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Center for Food Safety and Applied Nutrition Washington, D.C. 20206
Food and Drug Administration Washington, D.C. 20206
Department of Orthopaedics, University of Washington Medical Center Seattle, Washington 98195
Department of Orthopaedics and Rehabilitation, Yale University School of Medicine New Haven, Connecticut 06510
Correspondence: Address reprint requests to: Caren M. Gundberg, Ph.D., Department of Orthopaedics, Yale University School of Medicine, New Haven, Connecticut 06510.
Abstract
I. Introduction
THERE is increasing awareness among scientists, clinicians, policy makers, and the general public of the costs and health care problems associated with osteoporosis, the most common metabolic bone disease. If the disease could be prevented or effectively treated, then deaths, disabilities, and costs due to osteoporosis would be substantially reduced. To this end, considerable emphasis has been placed on developing and improving indicators of bone remodeling for 1) identifying people at risk, 2) early diagnosis, and 3) determining effective therapy for those with established disease. Although the clinician's ability to diagnose and monitor bone disease has improved in the past decade, there is still a need for more specific methods of assessing disturbances in bone metabolism.
Bone status can be assessed by dynamic histomorphometry of a biopsy specimen, but the technique is invasive, and results from a single core biopsy may not apply to other sites in the skeleton.
Footnotes
* Supported by the Food and Drug Administration and by NIH grants RO1-AR-38460 (to C.M.G.) and RO1-AR-37318 (to D.R.E.). Presented in part by Drs. Calvo and Gundberg to the Office of Technology Assessment as part of a report to the Congress of the United States on "Current Status and Future Needs for Osteoporosis Research, Education, and Medical Screening 1990–1993."
Consultant for and stockholder in Ostex International, Inc.
Consultant for BioMedical Technologies, Inc.
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