Autoimmune Thyroid Disease: Further Developments in Our Understanding*
A. P. WEETMAN and
A. M. McGREGOR
Department of Medicine, University of Sheffield Clinical Sciences Centre, Northern General Hospital Sheffield S5 7AU, United Kingdom
Department of Medicine, King's College Hospital School of Medicine and Dentistry London SE5 9PJ, United Kingdom
Correspondence: Address requests for reprints to: A. P. Weetman, M.D., D.Sc, F.R.C.P, Department of Medicine, Clinical Sciences Centre, Northern General Hospital, University of Sheffield, Sheffield S5 7AU, United Kingdom.
Abstract
DEVELOPMENTS in thyroid autoimmunity have been reviewed in thisjournal previously (1, 2), but since then there have been majoradvances in our understanding of the mechanisms responsiblefor autoimmunity in general, generated in large part by theapplication of novel molecular techniques. These discoveriesin turn have been used to develop new directions of researchin the field of autoimmune thyroid disorders, which will bethe subject of the present article. Approximately the same formathas been adopted as in our previous review (1), in an attemptto provide continuity, but we have chosen to emphasize particularlywork conducted during the last 5 yr for obvious reasons. Beforeconsidering the thyroid disorders themselves, however, it isworth providing a brief resume of what is known currently aboutimmunoregulation and self-tolerance in general, and then reviewingthe results obtained in animal models of thyroiditis that continueto generate otherwise unobtainable insights into pathogenesis.
Footnotes
* Work from the authors' laboratories cited in this review wassupported by the Wellcome Trust and the Sir Jules Thorn Trust.
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G. Kahaly, H. P. Dienes, J. Beyer, and G. Hommel Randomized, Double Blind, Placebo-Controlled Trial of Low Dose Iodide in Endemic Goiter
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