This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by RICHARDS, J. S. Search for Related Content PubMed PubMed Citation Articles by RICHARDS, J. S.

Hormonal Control of Gene Expression in the Ovary

Department of Cell Biology, Baylor College of Medicine Houston, Texas 77030

Correspondence: Address requests for reprints to: JoAnne S. Richards, Ph.D., Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030.

Abstract

The maturation of ovarian follicles involves several sequential stages: initiation, growth, selection, ovulation, and luteinization (Fig. 1). Although the factor(s) that initiates the growth of "resting" primordial follicles remain elusive, the key endocrine events controlling follicular growth in mammals have been known for many years. For example, once follicles have begun to grow, basal concentrations of the gonadotropins, FSH and LH, maintain growth up until the small antral stage. Small antral follicles are selected to continue growth by subtle increases in basal concentrations of gonadotropins, such as those that occur at menses in primates (1) or at the end of pregnancy in rodents (2). Once selected, the growing dominant follicle(s) acquires specific functional characteristics that permit it to differentiate to the preovulatory stage and synthesize estradiol. Increased serum estradiol triggers the surge of gonadotropins that, in turn, stimulates the preovulatory follicle(s) to ovulate and luteinize (form the corpus luteum).

This article has been cited by other articles:

				J. Kim, I. C. Bagchi, and M. K. Bagchi Control of ovulation in mice by progesterone receptor-regulated gene networks Mol. Hum. Reprod., December 1, 2009; 15(12): 821 - 828. [Abstract] [Full Text] [PDF]

				M. A. Edson, A. K. Nagaraja, and M. M. Matzuk The Mammalian Ovary from Genesis to Revelation Endocr. Rev., October 1, 2009; 30(6): 624 - 712. [Abstract] [Full Text] [PDF]

				F. Li, J. Liu, E.-S. Park, M. Jo, and T. E. Curry Jr. The B Cell Translocation Gene (BTG) Family in the Rat Ovary: Hormonal Induction, Regulation, and Impact on Cell Cycle Kinetics Endocrinology, August 1, 2009; 150(8): 3894 - 3902. [Abstract] [Full Text] [PDF]

				H. A. LaVoie and S. R. King Transcriptional Regulation of Steroidogenic Genes: STARD1, CYP11A1 and HSD3B Experimental Biology and Medicine, August 1, 2009; 234(8): 880 - 907. [Abstract] [Full Text] [PDF]

				B. J. Deroo, K. F. Rodriguez, J. F. Couse, K. J. Hamilton, J. B. Collins, S. F. Grissom, and K. S. Korach Estrogen Receptor {beta} Is Required for Optimal cAMP Production in Mouse Granulosa Cells Mol. Endocrinol., July 1, 2009; 23(7): 955 - 965. [Abstract] [Full Text] [PDF]

				J. Kim, I. C. Bagchi, and M. K. Bagchi Signaling by Hypoxia-Inducible Factors Is Critical for Ovulation In Mice Endocrinology, July 1, 2009; 150(7): 3392 - 3400. [Abstract] [Full Text] [PDF]

				Y. Ren, R. G. Cowan, R. M. Harman, and S. M. Quirk Dominant Activation of the Hedgehog Signaling Pathway in the Ovary Alters Theca Development and Prevents Ovulation Mol. Endocrinol., May 1, 2009; 23(5): 711 - 723. [Abstract] [Full Text] [PDF]

				Z. Liu, M. D. Rudd, I. Hernandez-Gonzalez, I. Gonzalez-Robayna, H.-Y. Fan, A. J. Zeleznik, and J. S. Richards FSH and FOXO1 Regulate Genes in the Sterol/Steroid and Lipid Biosynthetic Pathways in Granulosa Cells Mol. Endocrinol., May 1, 2009; 23(5): 649 - 661. [Abstract] [Full Text] [PDF]

				S. Lenie and J. Smitz Functional AR Signaling Is Evident in an In Vitro Mouse Follicle Culture Bioassay That Encompasses Most Stages of Folliculogenesis Biol Reprod, April 1, 2009; 80(4): 685 - 695. [Abstract] [Full Text] [PDF]

				M. F. Bouchard, H. Taniguchi, and R. S Viger The effect of human GATA4 gene mutations on the activity of target gonadal promoters J. Mol. Endocrinol., February 1, 2009; 42(2): 149 - 160. [Abstract] [Full Text] [PDF]

				J L Crawford, D A Heath, L J Haydon, B P Thomson, and D C Eckery Gene expression and secretion of LH and FSH in relation to gene expression of GnRH receptors in the brushtail possum (Trichosurus vulpecula) demonstrates highly conserved mechanisms Reproduction, January 1, 2009; 137(1): 129 - 140. [Abstract] [Full Text] [PDF]

				M.-N. Lague, M. Paquet, H.-Y. Fan, M. J. Kaartinen, S. Chu, S. P. Jamin, R. R. Behringer, P. J. Fuller, A. Mitchell, M. Dore, et al. Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression Carcinogenesis, November 1, 2008; 29(11): 2062 - 2072. [Abstract] [Full Text] [PDF]

				T. L. Steckler, J. S. Lee, W. Ye, E. K. Inskeep, and V. Padmanabhan Developmental Programming: Exogenous Gonadotropin Treatment Rescues Ovulatory Function But Does Not Completely Normalize Ovarian Function in Sheep Treated Prenatally with Testosterone Biol Reprod, October 1, 2008; 79(4): 686 - 695. [Abstract] [Full Text] [PDF]

				T. da Silva Faria, F. de Bittencourt Brasil, F. J B Sampaio, and C. da Fonte Ramos Maternal malnutrition during lactation alters the folliculogenesis and gonadotropins and estrogen isoforms ovarian receptors in the offspring at puberty J. Endocrinol., September 1, 2008; 198(3): 625 - 634. [Abstract] [Full Text] [PDF]

				I. Kawashima, T. Okazaki, N. Noma, M. Nishibori, Y. Yamashita, and M. Shimada Sequential exposure of porcine cumulus cells to FSH and/or LH is critical for appropriate expression of steroidogenic and ovulation-related genes that impact oocyte maturation in vivo and in vitro Reproduction, July 1, 2008; 136(1): 9 - 21. [Abstract] [Full Text] [PDF]

				M. P. Flynn, E. T. Maizels, A. B. Karlsson, T. McAvoy, J.-H. Ahn, A. C. Nairn, and M. Hunzicker-Dunn Luteinizing Hormone Receptor Activation in Ovarian Granulosa Cells Promotes Protein Kinase A-Dependent Dephosphorylation of Microtubule-Associated Protein 2D Mol. Endocrinol., July 1, 2008; 22(7): 1695 - 1710. [Abstract] [Full Text] [PDF]

				H.-Y. Fan, M. Shimada, Z. Liu, N. Cahill, N. Noma, Y. Wu, J. Gossen, and J. S. Richards Selective expression of KrasG12D in granulosa cells of the mouse ovary causes defects in follicle development and ovulation Development, June 15, 2008; 135(12): 2127 - 2137. [Abstract] [Full Text] [PDF]

				P. Zhao, A. De, Z. Hu, J. Li, S. M. Mulders, M. D. Sollewijn Gelpke, E.-K. Duan, and A. J. W. Hsueh Gonadotropin Stimulation of Ovarian Fractalkine Expression and Fractalkine Augmentation of Progesterone Biosynthesis by Luteinizing Granulosa Cells Endocrinology, June 1, 2008; 149(6): 2782 - 2789. [Abstract] [Full Text] [PDF]

				N. Forde, M. Mihm, M. J. Canty, A. E. Zielak, P. J. Baker, S. Park, P. Lonergan, G. W. Smith, P. M. Coussens, J. J. Ireland, et al. Differential expression of signal transduction factors in ovarian follicle development: a functional role for betaglycan and FIBP in granulosa cells in cattle Physiol Genomics, April 1, 2008; 33(2): 193 - 204. [Abstract] [Full Text] [PDF]

				K. Shkolnik, S. Ben-Dor, D. Galiani, A. Hourvitz, and N. Dekel Molecular characterization and bioinformatics analysis of Ncoa7B, a novel ovulation-associated and reproduction system-specific Ncoa7 isoform Reproduction, March 1, 2008; 135(3): 321 - 333. [Abstract] [Full Text] [PDF]

				H Cardenas, E Jimenez, and W F Pope Dihydrotestosterone influenced numbers of healthy follicles and follicular amounts of LH receptor mRNA during the follicular phase of the estrous cycle in gilts Reproduction, March 1, 2008; 135(3): 343 - 350. [Abstract] [Full Text] [PDF]

				J. Kim, M. Sato, Q. Li, J. P. Lydon, F. J. DeMayo, I. C. Bagchi, and M. K. Bagchi Peroxisome Proliferator-Activated Receptor {gamma} Is a Target of Progesterone Regulation in the Preovulatory Follicles and Controls Ovulation in Mice Mol. Cell. Biol., March 1, 2008; 28(5): 1770 - 1782. [Abstract] [Full Text] [PDF]

				S. Herath, E. J Williams, S. T Lilly, R. O Gilbert, H. Dobson, C. E Bryant, and I M. Sheldon Ovarian follicular cells have innate immune capabilities that modulate their endocrine function Reproduction, November 1, 2007; 134(5): 683 - 693. [Abstract] [Full Text] [PDF]

				M. Shimada, Y. Yanai, T. Okazaki, Y. Yamashita, V. Sriraman, M. C. Wilson, and J. S. Richards Synaptosomal-Associated Protein 25 Gene Expression Is Hormonally Regulated during Ovulation and Is Involved in Cytokine/Chemokine Exocytosis from Granulosa Cells Mol. Endocrinol., October 1, 2007; 21(10): 2487 - 2502. [Abstract] [Full Text] [PDF]

				C. Wang, E. R. Prossnitz, and S. K. Roy Expression of G Protein-Coupled Receptor 30 in the Hamster Ovary: Differential Regulation by Gonadotropins and Steroid Hormones Endocrinology, October 1, 2007; 148(10): 4853 - 4864. [Abstract] [Full Text] [PDF]

				S. Motola, M. Popliker, and A. Tsafriri Are Steroids Obligatory Mediators of Luteinizing Hormone/Human Chorionic Gonadotropin-Triggered Resumption of Meiosis in Mammals? Endocrinology, September 1, 2007; 148(9): 4458 - 4465. [Abstract] [Full Text] [PDF]

				K. Tamura, M. Matsushita, A. Endo, M. Kutsukake, and H. Kogo Effect of Insulin-Like Growth Factor-Binding Protein 7 on Steroidogenesis in Granulosa Cells Derived from Equine Chorionic Gonadotropin-Primed Immature Rat Ovaries Biol Reprod, September 1, 2007; 77(3): 485 - 491. [Abstract] [Full Text] [PDF]

				M. C. Russell, R. G. Cowan, R. M. Harman, A. L. Walker, and S. M. Quirk The Hedgehog Signaling Pathway in the Mouse Ovary Biol Reprod, August 1, 2007; 77(2): 226 - 236. [Abstract] [Full Text] [PDF]

				P.-J. He, M. Hirata, N. Yamauchi, S. Hashimoto, and M.-a. Hattori The disruption of circadian clockwork in differentiating cells from rat reproductive tissues as identified by in vitro real-time monitoring system J. Endocrinol., June 1, 2007; 193(3): 413 - 420. [Abstract] [Full Text] [PDF]

				T. M Lovell, S. L Al-Musawi, R. T Gladwell, and P. G Knight Gonadotrophins modulate hormone secretion and steady-state mRNA levels for activin receptors (type I, IIA, IIB) and inhibin co-receptor (betaglycan) in granulosa and theca cells from chicken prehierarchical and preovulatory follicles Reproduction, June 1, 2007; 133(6): 1159 - 1168. [Abstract] [Full Text] [PDF]

				D. L. Russell and R. L. Robker Molecular mechanisms of ovulation: co-ordination through the cumulus complex Hum. Reprod. Update, May 1, 2007; 13(3): 289 - 312. [Abstract] [Full Text] [PDF]

				Y. Lu, A. Amleh, J. Sun, X. Jin, S. D. McCullough, R. Baer, D. Ren, R. Li, and Y. Hu Ubiquitination and Proteasome-Mediated Degradation of BRCA1 and BARD1 during Steroidogenesis in Human Ovarian Granulosa Cells Mol. Endocrinol., March 1, 2007; 21(3): 651 - 663. [Abstract] [Full Text] [PDF]

				D. Saxena, R. Escamilla-Hernandez, L. Little-Ihrig, and A. J. Zeleznik Liver Receptor Homolog-1 and Steroidogenic Factor-1 Have Similar Actions on Rat Granulosa Cell Steroidogenesis Endocrinology, February 1, 2007; 148(2): 726 - 734. [Abstract] [Full Text] [PDF]

				M.R. Massai, M.L. Forcelledo, V. Brache, A.S. Tejada, A.M. Salvatierra, M.V. Reyes, F. Alvarez, A. Faundes, and H.B. Croxatto Does meloxicam increase the incidence of anovulation induced by single administration of levonorgestrel in emergency contraception? A pilot study Hum. Reprod., February 1, 2007; 22(2): 434 - 439. [Abstract] [Full Text] [PDF]

				L. Liu and W. Ge Growth Differentiation Factor 9 and Its Spatiotemporal Expression and Regulation in the Zebrafish Ovary Biol Reprod, February 1, 2007; 76(2): 294 - 302. [Abstract] [Full Text] [PDF]

				K. A Brown, K. Sayasith, N. Bouchard, J. G Lussier, and J. Sirois Molecular cloning of equine 17{beta}-hydroxysteroid dehydrogenase type 1 and its downregulation during follicular luteinization in vivo J. Mol. Endocrinol., January 1, 2007; 38(1): 67 - 78. [Abstract] [Full Text] [PDF]

				N. Tinfo and C. Komar Potential role for peroxisome proliferator-activated receptor {gamma} in regulating luteal lifespan in the rat Reproduction, January 1, 2007; 133(1): 187 - 196. [Abstract] [Full Text] [PDF]

				N. Andric and M. Ascoli A Delayed Gonadotropin-Dependent and Growth Factor-Mediated Activation of the Extracellular Signal-Regulated Kinase 1/2 Cascade Negatively Regulates Aromatase Expression in Granulosa Cells Mol. Endocrinol., December 1, 2006; 20(12): 3308 - 3320. [Abstract] [Full Text] [PDF]

				V. Morales, I. Gonzalez-Robayna, M. P. Santana, I. Hernandez, and L. F. Fanjul Tumor Necrosis Factor-{alpha} Activates Transcription of Inducible Repressor Form of 3',5'-Cyclic Adenosine 5'-Monophosphate-Responsive Element Binding Modulator and Represses P450 Aromatase and Inhibin {alpha}-Subunit Expression in Rat Ovarian Granulosa Cells by a p44/42 Mitogen-Activated Protein Kinase-Dependent Mechanism Endocrinology, December 1, 2006; 147(12): 5932 - 5939. [Abstract] [Full Text] [PDF]

				F. J. Schweigert, B. Gericke, W. Wolfram, U. Kaisers, and J. W. Dudenhausen Peptide and protein profiles in serum and follicular fluid of women undergoing IVF Hum. Reprod., November 1, 2006; 21(11): 2960 - 2968. [Abstract] [Full Text] [PDF]

				M. A. Lazzaro, D. Pepin, N. Pescador, B. D. Murphy, B. C. Vanderhyden, and D. J. Picketts The Imitation Switch Protein SNF2L Regulates Steroidogenic Acute Regulatory Protein Expression during Terminal Differentiation of Ovarian Granulosa Cells Mol. Endocrinol., October 1, 2006; 20(10): 2406 - 2417. [Abstract] [Full Text] [PDF]

				A. De, J.-I. Park, K. Kawamura, R. Chen, C. Klein, R. Rauch, S. M. Mulders, M. D. Sollewijn Gelpke, and A. J. W. Hsueh Intraovarian Tumor Necrosis Factor-Related Weak Inducer of Apoptosis/Fibroblast Growth Factor-Inducible-14 Ligand-Receptor System Limits Ovarian Preovulatory Follicles from Excessive Luteinization Mol. Endocrinol., October 1, 2006; 20(10): 2528 - 2538. [Abstract] [Full Text] [PDF]

				M. Q. Panzan, J. M. S. Junior, E. L. A. da Motta, E. F. Haapalainen, M. de Jesus Simoes, H. A. Baptista, M. A. Haidar, and E. C. Baracat Metoclopramide-induced hyperprolactinaemia caused marked decline in pinopodes and pregnancy rates in mice Hum. Reprod., October 1, 2006; 21(10): 2514 - 2520. [Abstract] [Full Text] [PDF]

				K.R. Barnett, C. Schilling, C.R. Greenfeld, D. Tomic, and J.A. Flaws Ovarian follicle development and transgenic mouse models Hum. Reprod. Update, September 1, 2006; 12(5): 537 - 555. [Abstract] [Full Text] [PDF]

				K. A. Brown, M. Dore, J. G. Lussier, and J. Sirois Human Chorionic Gonadotropin-Dependent Up-Regulation of Genes Responsible for Estrogen Sulfoconjugation and Export in Granulosa Cells of Luteinizing Preovulatory Follicles Endocrinology, September 1, 2006; 147(9): 4222 - 4233. [Abstract] [Full Text] [PDF]

				R. Shao, B. Weijdegard, K. Ljungstrom, A. Friberg, C. Zhu, X. Wang, Y. Zhu, J. Fernandez-Rodriguez, E. Egecioglu, E. Rung, et al. Nuclear progesterone receptor A and B isoforms in mouse fallopian tube and uterus: implications for expression, regulation, and cellular function Am J Physiol Endocrinol Metab, July 1, 2006; 291(1): E59 - E72. [Abstract] [Full Text] [PDF]

				B. Campbell, J. Dickey, B. Beckman, G. Young, A. Pierce, H. Fukada, and P. Swanson Previtellogenic Oocyte Growth in Salmon: Relationships among Body Growth, Plasma Insulin-Like Growth Factor-1, Estradiol-17beta, Follicle-Stimulating Hormone and Expression of Ovarian Genes for Insulin-Like Growth Factors, Steroidogenic-Acute Regulatory Protein and Receptors for Gonadotropins, Growth Hormone, and Somatolactin Biol Reprod, July 1, 2006; 75(1): 34 - 44. [Abstract] [Full Text] [PDF]

				K A Brown, D Boerboom, N Bouchard, M Dore, J G Lussier, and J Sirois Human chorionic gonadotropin-dependent induction of an equine aldo-keto reductase (AKR1C23) with 20{alpha}-hydroxysteroid dehydrogenase activity during follicular luteinization in vivo. J. Mol. Endocrinol., June 1, 2006; 36(3): 449 - 461. [Abstract] [Full Text] [PDF]

				M Kusakabe, I Nakamura, J Evans, P Swanson, and G Young Changes in mRNAs encoding steroidogenic acute regulatory protein, steroidogenic enzymes and receptors for gonadotropins during spermatogenesis in rainbow trout testes. J. Endocrinol., June 1, 2006; 189(3): 541 - 554. [Abstract] [Full Text] [PDF]

				I. Hernandez-Gonzalez, I. Gonzalez-Robayna, M. Shimada, C. M. Wayne, S. A. Ochsner, L. White, and J. S. Richards Gene Expression Profiles of Cumulus Cell Oocyte Complexes during Ovulation Reveal Cumulus Cells Express Neuronal and Immune-Related Genes: Does this Expand Their Role in the Ovulation Process? Mol. Endocrinol., June 1, 2006; 20(6): 1300 - 1321. [Abstract] [Full Text] [PDF]

				M. Shimada, I. Hernandez-Gonzalez, I. Gonzalez-Robayna, and J. S. Richards Paracrine and Autocrine Regulation of Epidermal Growth Factor-Like Factors in Cumulus Oocyte Complexes and Granulosa Cells: Key Roles for Prostaglandin Synthase 2 and Progesterone Receptor Mol. Endocrinol., June 1, 2006; 20(6): 1352 - 1365. [Abstract] [Full Text] [PDF]

				J. Weck and K. E. Mayo Switching of NR5A Proteins Associated with the Inhibin {alpha}-Subunit Gene Promoter after Activation of the Gene in Granulosa Cells Mol. Endocrinol., May 1, 2006; 20(5): 1090 - 1103. [Abstract] [Full Text] [PDF]

				M. Conti, M. Hsieh, J.-Y. Park, and Y.-Q. Su Role of the Epidermal Growth Factor Network in Ovarian Follicles Mol. Endocrinol., April 1, 2006; 20(4): 715 - 723. [Abstract] [Full Text] [PDF]

				C. Ko, M. C. Gieske, L. Al-Alem, Y. Hahn, W. Su, M. C. Gong, M. Iglarz, and Y. Koo Endothelin-2 in Ovarian Follicle Rupture Endocrinology, April 1, 2006; 147(4): 1770 - 1779. [Abstract] [Full Text] [PDF]

				A Hourvitz, E Gershon, J D Hennebold, S Elizur, E Maman, C Brendle, E Y Adashi, and N Dekel Ovulation-selective genes: the generation and characterization of an ovulatory-selective cDNA library. J. Endocrinol., March 1, 2006; 188(3): 531 - 548. [Abstract] [Full Text] [PDF]

				S. Perlman, T. Bouquin, B. van den Hazel, T.H. Jensen, H.T. Schambye, S. Knudsen, and J.S. Okkels Transcriptome analysis of FSH and FSH variant stimulation in granulosa cells from IVM patients reveals novel regulated genes Mol. Hum. Reprod., March 1, 2006; 12(3): 135 - 144. [Abstract] [Full Text] [PDF]

				J. Banerjee and C. M Komar Effects of luteinizing hormone on peroxisome proliferator-activated receptor {gamma} in the rat ovary before and after the gonadotropin surge Reproduction, January 1, 2006; 131(1): 93 - 101. [Abstract] [Full Text] [PDF]

				R. Toyama, T. Fujimori, Y. Nabeshima, Y. Itoh, Y. Tsuji, R. Y. Osamura, and Y.-I. Nabeshima Impaired Regulation of Gonadotropins Leads to the Atrophy of the Female Reproductive System in klotho-Deficient Mice Endocrinology, January 1, 2006; 147(1): 120 - 129. [Abstract] [Full Text] [PDF]

				J. A. MacLean II, M. K. Rao, K. M.H. Doyle, J. S. Richards, and M. F. Wilkinson Regulation of the Rhox5 Homeobox Gene in Primary Granulosa Cells: Preovulatory Expression and Dependence on SP1/SP3 and GABP Biol Reprod, December 1, 2005; 73(6): 1126 - 1134. [Abstract] [Full Text] [PDF]

				T. Baba, J. Mimura, N. Nakamura, N. Harada, M. Yamamoto, K.-i. Morohashi, and Y. Fujii-Kuriyama Intrinsic Function of the Aryl Hydrocarbon (Dioxin) Receptor as a Key Factor in Female Reproduction Mol. Cell. Biol., November 15, 2005; 25(22): 10040 - 10051. [Abstract] [Full Text] [PDF]

				A.L. Filby and C.R. Tyler Molecular Characterization of Estrogen Receptors 1, 2a, and 2b and Their Tissue and Ontogenic Expression Profiles in Fathead Minnow (Pimephales promelas) Biol Reprod, October 1, 2005; 73(4): 648 - 662. [Abstract] [Full Text] [PDF]

				N. Takamoto, I. Kurihara, K. Lee, F. J. DeMayo, M.-J. Tsai, and S. Y. Tsai Haploinsufficiency of Chicken Ovalbumin Upstream Promoter Transcription Factor II in Female Reproduction Mol. Endocrinol., September 1, 2005; 19(9): 2299 - 2308. [Abstract] [Full Text] [PDF]

				F. X. Donadeu and M. Ascoli The Differential Effects of the Gonadotropin Receptors on Aromatase Expression in Primary Cultures of Immature Rat Granulosa Cells Are Highly Dependent on the Density of Receptors Expressed and the Activation of the Inositol Phosphate Cascade Endocrinology, September 1, 2005; 146(9): 3907 - 3916. [Abstract] [Full Text] [PDF]

				J. F. Couse, M. M. Yates, B. J. Deroo, and K. S. Korach Estrogen Receptor-{beta} Is Critical to Granulosa Cell Differentiation and the Ovulatory Response to Gonadotropins Endocrinology, August 1, 2005; 146(8): 3247 - 3262. [Abstract] [Full Text] [PDF]

				F.-Q. Yu, C.-S. Han, W. Yang, X. Jin, Z.-Y. Hu, and Y.-X. Liu Activation of the p38 MAPK pathway by follicle-stimulating hormone regulates steroidogenesis in granulosa cells differentially J. Endocrinol., July 1, 2005; 186(1): 85 - 96. [Abstract] [Full Text] [PDF]

				D. S. Burns, F. Jimenez-Krassel, J. L.H. Ireland, P. G. Knight, and J. J. Ireland Numbers of Antral Follicles During Follicular Waves in Cattle: Evidence for High Variation Among Animals, Very High Repeatability in Individuals, and an Inverse Association with Serum Follicle-Stimulating Hormone Concentrations Biol Reprod, July 1, 2005; 73(1): 54 - 62. [Abstract] [Full Text] [PDF]

				K. Ogiwara, N. Takano, M. Shinohara, M. Murakami, and T. Takahashi Gelatinase A and membrane-type matrix metalloproteinases 1 and 2 are responsible for follicle rupture during ovulation in the medaka PNAS, June 14, 2005; 102(24): 8442 - 8447. [Abstract] [Full Text] [PDF]

				J. W. Kim, J. C. Havelock, B. R. Carr, and G. R. Attia The Orphan Nuclear Receptor, Liver Receptor Homolog-1, Regulates Cholesterol Side-Chain Cleavage Cytochrome P450 Enzyme in Human Granulosa Cells J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1678 - 1685. [Abstract] [Full Text] [PDF]

				K. R. von Schalburg, M. L. Rise, G. D. Brown, W. S. Davidson, and B. F. Koop A Comprehensive Survey of the Genes Involved in Maturation and Development of the Rainbow Trout Ovary Biol Reprod, March 1, 2005; 72(3): 687 - 699. [Abstract] [Full Text] [PDF]

				N. El-Nefiawy, K. Abdel-Hakim, and N. Kanayama The selective prostaglandin EP4 agonist, APS-999 Na, induces follicular growth and maturation in the rat ovary Eur. J. Endocrinol., February 1, 2005; 152(2): 315 - 323. [Abstract] [Full Text] [PDF]

				C. M. Bastida, A. Cremades, M. T. Castells, A. J. Lopez-Contreras, C. Lopez-Garcia, F. Tejada, and R. Penafiel Influence of Ovarian Ornithine Decarboxylase in Folliculogenesis and Luteinization Endocrinology, February 1, 2005; 146(2): 666 - 674. [Abstract] [Full Text] [PDF]

				Y. Wu, S. Ghosh, Y. Nishi, T. Yanase, H. Nawata, and Y. Hu The Orphan Nuclear Receptors NURR1 and NGFI-B Modulate Aromatase Gene Expression in Ovarian Granulosa Cells: A Possible Mechanism for Repression of Aromatase Expression upon Luteinizing Hormone Surge Endocrinology, January 1, 2005; 146(1): 237 - 246. [Abstract] [Full Text] [PDF]

				T.-T. Wong and Y. Zohar Novel Expression of Gonadotropin Subunit Genes in Oocytes of the Gilthead Seabream (Sparus aurata) Endocrinology, November 1, 2004; 145(11): 5210 - 5220. [Abstract] [Full Text] [PDF]

				K. M. H. Doyle, D. L. Russell, V. Sriraman, and J. S. Richards Coordinate Transcription of the ADAMTS-1 Gene by Luteinizing Hormone and Progesterone Receptor Mol. Endocrinol., October 1, 2004; 18(10): 2463 - 2478. [Abstract] [Full Text] [PDF]

				J. F. Couse, M. M. Yates, R. Sanford, A. Nyska, J. H. Nilson, and K. S. Korach Formation of Cystic Ovarian Follicles Associated with Elevated Luteinizing Hormone Requires Estrogen Receptor-{beta} Endocrinology, October 1, 2004; 145(10): 4693 - 4702. [Abstract] [Full Text] [PDF]

				M. Shimada, M. Nishibori, Y. Yamashita, J. Ito, T. Mori, and J. S. Richards Down-Regulated Expression of A Disintegrin and Metalloproteinase with Thrombospondin-Like Repeats-1 by Progesterone Receptor Antagonist Is Associated with Impaired Expansion of Porcine Cumulus-Oocyte Complexes Endocrinology, October 1, 2004; 145(10): 4603 - 4614. [Abstract] [Full Text] [PDF]

				H. Walzel, J. Brock, R. Pohland, J. Vanselow, W. Tomek, F. Schneider, and U. Tiemann Effects of galectin-1 on regulation of progesterone production in granulosa cells from pig ovaries in vitro Glycobiology, October 1, 2004; 14(10): 871 - 881. [Abstract] [Full Text] [PDF]

				S. Chu, Y. Nishi, T. Yanase, H. Nawata, and P. J. Fuller Transrepression of Estrogen Receptor {beta} Signaling by Nuclear Factor-{kappa}B in Ovarian Granulosa Cells Mol. Endocrinol., August 1, 2004; 18(8): 1919 - 1928. [Abstract] [Full Text] [PDF]

				N. Sekar and J. D. Veldhuis Involvement of Sp1 and SREBP-1a in transcriptional activation of the LDL receptor gene by insulin and LH in cultured porcine granulosa-luteal cells Am J Physiol Endocrinol Metab, July 1, 2004; 287(1): E128 - E135. [Abstract] [Full Text] [PDF]

				L. M. Salvador, M. P. Flynn, J. Avila, S. Reierstad, E. T. Maizels, H. Alam, Y. Park, J. D. Scott, D. W. Carr, and M. Hunzicker-Dunn Neuronal Microtubule-associated Protein 2D Is a Dual A-kinase Anchoring Protein Expressed in Rat Ovarian Granulosa Cells J. Biol. Chem., June 25, 2004; 279(26): 27621 - 27632. [Abstract] [Full Text] [PDF]

				J. D. Hennebold Characterization of the ovarian transcriptome through the use of differential analysis of gene expression methodologies Hum. Reprod. Update, May 1, 2004; 10(3): 227 - 239. [Abstract] [Full Text] [PDF]

				T. Kajitani, T. Mizutani, K. Yamada, T. Yazawa, T. Sekiguchi, M. Yoshino, H. Kawata, and K. Miyamoto Cloning and Characterization of Granulosa Cell High-Mobility Group (HMG)-Box Protein-1, a Novel HMG-Box Transcriptional Regulator Strongly Expressed in Rat Ovarian Granulosa Cells Endocrinology, May 1, 2004; 145(5): 2307 - 2318. [Abstract] [Full Text] [PDF]

				C. Hegele-Hartung, P. Siebel, O. Peters, D. Kosemund, G. Muller, A. Hillisch, A. Walter, J. Kraetzschmar, and K.-H. Fritzemeier Impact of isotype-selective estrogen receptor agonists on ovarian function PNAS, April 6, 2004; 101(14): 5129 - 5134. [Abstract] [Full Text] [PDF]

				K. A. Brown, D. Boerboom, N. Bouchard, M. Dore, J. G. Lussier, and J. Sirois Human Chorionic Gonadotropin-Dependent Regulation of 17{beta}-Hydroxysteroid Dehydrogenase Type 4 in Preovulatory Follicles and Its Potential Role in Follicular Luteinization Endocrinology, April 1, 2004; 145(4): 1906 - 1915. [Abstract] [Full Text] [PDF]

				Y.-L. Kang, H. Li, W.-H. Chen, Y.-S. Tzeng, Y.-L. Lai, and H. M. Hsieh-Li A Novel PEPP Homeobox Gene, TOX, Is Highly Glutamic Acid Rich and Specifically Expressed in Murine Testis and Ovary Biol Reprod, March 1, 2004; 70(3): 828 - 836. [Abstract] [Full Text] [PDF]

				R. Shao, F.-P. Zhang, E. Rung, J. J. Palvimo, I. Huhtaniemi, and H. Billig Inhibition of Small Ubiquitin-Related Modifier-1 Expression by Luteinizing Hormone Receptor Stimulation is Linked to Induction of Progesterone Receptor during Ovulation in Mouse Granulosa Cells Endocrinology, January 1, 2004; 145(1): 384 - 392. [Abstract] [Full Text] [PDF]

				M. Hsieh, S. M. Mulders, R. R. Friis, A. Dharmarajan, and J. S. Richards Expression and Localization of Secreted Frizzled-Related Protein-4 in the Rodent Ovary: Evidence for Selective Up-Regulation in Luteinized Granulosa Cells Endocrinology, October 1, 2003; 144(10): 4597 - 4606. [Abstract] [Full Text] [PDF]

				B. Sisco, L. J. Hagemann, A. N. Shelling, and P. L. Pfeffer Isolation of Genes Differentially Expressed in Dominant and Subordinate Bovine Follicles Endocrinology, September 1, 2003; 144(9): 3904 - 3913. [Abstract] [Full Text] [PDF]

				C. Ko, N. A. Grieshaber, I. Ji, and T. H. Ji Follicle-Stimulating Hormone Suppresses Cytosolic 3,5,3'-Triiodothyronine-Binding Protein Messenger Ribonucleic Acid Expression in Rat Granulosa Cells Endocrinology, June 1, 2003; 144(6): 2360 - 2367. [Abstract] [Full Text] [PDF]

				J. F. Couse, M. M. Yates, V. R. Walker, and K. S. Korach Characterization of the Hypothalamic-Pituitary-Gonadal Axis in Estrogen Receptor (ER) Null Mice Reveals Hypergonadism and Endocrine Sex Reversal in Females Lacking ER{alpha} But Not ER{beta} Mol. Endocrinol., June 1, 2003; 17(6): 1039 - 1053. [Abstract] [Full Text] [PDF]

				J.-Y. Park, F. Richard, S.-Y. Chun, J.-H. Park, E. Law, K. Horner, S-L C. Jin, and M. Conti Phosphodiesterase Regulation Is Critical for the Differentiation and Pattern of Gene Expression in Granulosa Cells of the Ovarian Follicle Mol. Endocrinol., June 1, 2003; 17(6): 1117 - 1130. [Abstract] [Full Text] [PDF]

				T. Yazawa, T. Mizutani, K. Yamada, H. Kawata, T. Sekiguchi, M. Yoshino, T. Kajitani, Z. Shou, and K. Miyamoto Involvement of Cyclic Adenosine 5'-Monophosphate Response Element-Binding Protein, Steroidogenic Factor 1, and Dax-1 in the Regulation of Gonadotropin-Inducible Ovarian Transcription Factor 1 Gene Expression by Follicle-Stimulating Hormone in Ovarian Granulosa Cells Endocrinology, May 1, 2003; 144(5): 1920 - 1930. [Abstract] [Full Text] [PDF]

				N. C. Zachos, R. B. Billiar, E. D. Albrecht, and G. J. Pepe Developmental Regulation of Follicle-Stimulating Hormone Receptor Messenger RNA Expression in the Baboon Fetal Ovary Biol Reprod, May 1, 2003; 68(5): 1911 - 1917. [Abstract] [Full Text] [PDF]

				Y. Yoshiura, B. Senthilkumaran, M. Watanabe, Y. Oba, T. Kobayashi, and Y. Nagahama Synergistic Expression of Ad4BP/SF-1 and Cytochrome P-450 Aromatase (Ovarian Type) in the Ovary of Nile Tilapia, Oreochromis niloticus, During Vitellogenesis Suggests Transcriptional Interaction Biol Reprod, May 1, 2003; 68(5): 1545 - 1553. [Abstract] [Full Text] [PDF]

				D. L. Russell, K. M. H. Doyle, I. Gonzales-Robayna, C. Pipaon, and J. S. Richards Egr-1 Induction in Rat Granulosa Cells by Follicle-Stimulating Hormone and Luteinizing Hormone: Combinatorial Regulation By Transcription Factors Cyclic Adenosine 3',5'-Monophosphate Regulatory Element Binding Protein, Serum Response Factor, Sp1, and Early Growth Response Factor-1 Mol. Endocrinol., April 1, 2003; 17(4): 520 - 533. [Abstract] [Full Text] [PDF]

				G. W. Sun, H. Kobayashi, M. Suzuki, N. Kanayama, and T. Terao Follicle-Stimulating Hormone and Insulin-Like Growth Factor I Synergistically Induce Up-Regulation of Cartilage Link Protein (Crtl1) via Activation of Phosphatidylinositol-Dependent Kinase/Akt in Rat Granulosa Cells Endocrinology, March 1, 2003; 144(3): 793 - 801. [Abstract] [Full Text] [PDF]

				V. Sriraman, S. C. Sharma, and J. S. Richards Transactivation of the Progesterone Receptor Gene in Granulosa Cells: Evidence that Sp1/Sp3 Binding Sites in the Proximal Promoter Play a Key Role in Luteinizing Hormone Inducibility Mol. Endocrinol., March 1, 2003; 17(3): 436 - 449. [Abstract] [Full Text] [PDF]

				R. Shao, E. Markstrom, P. A. Friberg, M. Johansson, and H. Billig Expression of Progesterone Receptor (PR) A and B Isoforms in Mouse Granulosa Cells: Stage-Dependent PR-Mediated Regulation of Apoptosis and Cell Proliferation Biol Reprod, March 1, 2003; 68(3): 914 - 921. [Abstract] [Full Text] [PDF]

				J. Cottom, L. M. Salvador, E. T. Maizels, S. Reierstad, Y. Park, D. W. Carr, M. A. Davare, J. W. Hell, S. S. Palmer, P. Dent, et al. Follicle-stimulating Hormone Activates Extracellular Signal-regulated Kinase but Not Extracellular Signal-regulated Kinase Kinase through a 100-kDa Phosphotyrosine Phosphatase J. Biol. Chem., February 21, 2003; 278(9): 7167 - 7179. [Abstract] [Full Text] [PDF]